Calbindin 2

A calbindin protein that is differentially expressed in distinct populations of NEURONS throughout the vertebrate and invertebrate NERVOUS SYSTEM, and modulates intrinsic neuronal excitability and influences LONG-TERM POTENTIATION. It is also found in LUNG, TESTIS, OVARY, KIDNEY, and BREAST, and is expressed in many tumor types found in these tissues. It is often used as an immunohistochemical marker for MESOTHELIOMA.

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Networked: 1002 relevant articles (23 outcomes, 102 trials/studies)

Relationship Network

Bio-Agent Context: Research Results

Experts

1.	Schwaller, Beat: 15 articles (10/2019 - 11/2004)
2.	Young, Robert H: 11 articles (01/2021 - 02/2005)
3.	McCluggage, W Glenn: 10 articles (01/2021 - 02/2005)
4.	Oliva, Esther: 9 articles (01/2021 - 01/2005)
5.	Blum, Walter: 9 articles (10/2019 - 07/2013)
6.	Ordóñez, Nelson G: 9 articles (07/2014 - 08/2003)
7.	Brüning, Thomas: 8 articles (01/2021 - 05/2010)
8.	Johnen, Georg: 8 articles (01/2021 - 05/2010)
9.	Raiko, Irina: 8 articles (01/2021 - 05/2010)
10.	Taeger, Dirk: 7 articles (01/2021 - 01/2017)

Related Diseases

1.	Mesothelioma 10/01/1998 - "Among these, calretinin generated a great deal of interest, but the number of studies evaluating the practical use of calretinin immunostaining in the diagnosis of mesothelioma is limited, and the study results are controversial. " 03/01/2023 - "Histopathological examination revealed mesothelioma, and immunohistochemical staining was positive for calretinin. " 07/01/2021 - "These and one other epithelial mesothelioma were also positive for calretinin. " 10/01/2020 - "Calretinin was expressed in 82% of all types of mesotheliomas but in only 48% of sarcomatoid mesotheliomas. " 01/01/2020 - "On the microarrays, the conventional mesothelial markers calretinin, WT1, D2-40, and CK5/6 had sensitivities for epithelioid mesothelioma of 94%, 90%, 96%, and 91%, respectively. "
2.	Adenocarcinoma 01/01/2019 - "Limited immuno-panel of Calretinin and Ber-EP4 had a high positive and negative predictive value and is cost-effective in resource limited set-up for identification of adenocarcinoma cells and reactive mesothelial cells in challenging cases of serous effusions." 01/01/2021 - "In this study, we explored the incidence of calretinin expression in pancreatic ductal adenocarcinoma. " 01/01/2019 - "Conclusion: The current study demonstrated that a panel marker, comprising EMA, Ber-EP4, and calretinin can be used for differentiating between cases of metastatic adenocarcinoma and benign mesothelium. " 04/01/2009 - "The aim of our study was to determine the value of a panel that consisted of one epithelial marker (MOC-31) and two mesothelial markers (D2-40 and calretinin) for distinguishing between reactive mesothelial cells (RMCs) and adenocarcinomas (ACs) in effusion fluids. " 01/01/2023 - "Calretinin had 99% specificity and 98% sensitivity for indicating a mesothelial phenotype, while BerEp4 distinguished the adenocarcinoma cases with 98% specificity and 99% sensitivity. "
3.	Ganglion Cysts (Ganglion) 04/01/2017 - "The concordance of detection of ganglion cells and nerve fibers, and thereby diagnosis of Hirschsprung's and non-HD using calretinin and the gold standard was statistically in strong agreement (κ = 0.749, 95% confidence interval: 0.635-0.863). " 01/01/2019 - "Calretinin is helpful in identifying ganglion cells; however, it cannot replace an experienced paediatric pathologist. " 07/01/2017 - "Complete study of 13 appendices in TCA showed absence of ganglion cells, hypertrophic nerves, AChE activity, and calretinin staining. " 07/01/2015 - "Overall sensitivity in our study to diagnose presence or absence of ganglion cells by calretinin immunohistochemistry was 100% and the specificity is 97.44% with positive and negative predictive value of 84.62 % and 100 % respectively. " 08/25/2008 - "Immunohistochemical studies demonstrated colocalization of CFP with the ganglion cell markers NF-L, NeuN, Brn3a, and calretinin. "
4.	Neoplasms (Cancer) 11/01/1997 - "Calretinin is a very useful marker for positive identification of normal and tumor mesothelial cells in serous effusions." 01/01/2008 - "Additional immunocytochemical staining with the proposed panel of calretinin, EMA, HMFG-2 and CEA improved sensitivity for malignancy in general from 78% to 96% and specificity from 73% to 91%. " 02/01/2005 - "Although CD99 and calretinin are often expressed in these tumors, they are much less specific and not as helpful in the differential diagnosis. " 06/01/2015 - "Immunohistochemistry studies of LATS1, LATS2, Pax8, and calretinin were performed on normal ovary, fallopian tube, normal endometrium, and ovarian tumor sections. " 07/01/2008 - "The aim of this study was to determine whether immunohistochemistry for calretinin allows identification of cutaneous adnexal tumors with follicular differentiation towards cells of the outer root sheath. "
5.	Carcinoma (Carcinomatosis) 01/01/2021 - "The incidence of calretinin expression was 15% in poorly differentiated/undifferentiated carcinomas (vs. 6% in well/moderately differentiated carcinomas, p=0.03). " 12/01/2018 - "Herein, we compared the performance of GATA3 and TTF1 to the traditional markers used for mesonephric carcinomas, CD10 and calretinin. " 12/01/2018 - "A Comparison of GATA3, TTF1, CD10, and Calretinin in Identifying Mesonephric and Mesonephric-like Carcinomas of the Gynecologic Tract." 07/01/2017 - "Calretinin expression was found in 55.1% of the IBCs and was strongly associated with carcinoma with medullary features (P = 0.014) and type II IDC-NST (P < 0.001), while type I IDC-NST correlated (P < 0.001) with a lack of calretinin expression. " 07/01/2017 - " aimed to investigate the utility of CD90, a cancer stem cell marker, in the differential diagnosis of MM and lung carcinoma, its prognostic significance and compare its value with that of Calretinin. "

Related Drugs and Biologics

1.	Inhibins (Inhibin)
2.	Parvalbumins
3.	Thrombomodulin
4.	Keratin-5 (Keratin 5)
5.	Calcium-Binding Proteins
6.	Calbindins
7.	Antibodies
8.	Vimentin
9.	Keratins (Keratin)
10.	Carcinoembryonic Antigen

Related Therapies and Procedures

1.	Therapeutics
2.	Lasers (Laser)
3.	Embolectomy
4.	Colectomy
5.	Neoadjuvant Therapy