Calbindins

Calcium-binding proteins that are found in DISTAL KIDNEY TUBULES, INTESTINES, BRAIN, and other tissues where they bind, buffer and transport cytoplasmic calcium. Calbindins possess a variable number of EF-HAND MOTIFS which contain calcium-binding sites. Some isoforms are regulated by VITAMIN D.

Also Known As:

Networked: 376 relevant articles (13 outcomes, 37 trials/studies)

Relationship Network

Bio-Agent Context: Research Results

Experts

1.	Hwang, In Koo: 6 articles (09/2017 - 05/2003)
2.	Chun, Myung-Hoon: 5 articles (01/2012 - 04/2005)
3.	Mucke, Lennart: 4 articles (11/2015 - 10/2005)
4.	Kim, In-Beom: 4 articles (01/2012 - 04/2005)
5.	Kang, Tae-Cheon: 4 articles (06/2005 - 05/2003)
6.	Won, Moo Ho: 4 articles (06/2005 - 05/2003)
7.	Aleksunes, Lauren M: 3 articles (07/2022 - 01/2018)
8.	George, Blessy: 3 articles (07/2022 - 01/2018)
9.	Joy, Melanie S: 3 articles (07/2022 - 01/2018)
10.	Vázquez-Borsetti, Pablo: 3 articles (11/2020 - 01/2016)

Related Diseases

1.	Ganglion Cysts (Ganglion) 10/06/2000 - "In the aged rats the number of calbindin-immunoreactive sympathetic neurons of the major pelvic ganglion was dramatically reduced. " 01/01/2019 - "In marmoset, calbindin immunoreactivity in the ganglion cell layer was absent from ganglion cells but present in ON ChAT cells. " 02/01/2018 - "Neurochemical characteristics of calbindin-like immunoreactive coeliac-cranial mesenteric ganglion complex (CCMG) neurons supplying the pre-pyloric region of the porcine stomach." 01/01/2016 - "Types and density of calbindin D28k-immunoreactive ganglion cells in mouse retina." 05/01/2015 - "Calbindin-immunopositive neurons per myenteric ganglion were 36% in SPF, 24% in GF, and 52% in CONV animals. "
2.	Gliosis 10/31/2023 - "Histological examination revealed reduced Purkinje cell count with ultrastructural degeneration, irregularly arranged nerve fibers in the molecular layer, astrogliosis, and significantly decreased calbindin-immunostaining compared to the control. " 05/03/2022 - "Western blot analysis of cerebellar extracts demonstrated reduced calbindin staining in Mgat5-/-:Npc1-/- mice compared to Mgat5+/+:Npc1-/- mutant mice, and immunofluorescent staining of cerebellar sections indicated decreased levels of Purkinje neurons and increased astrogliosis in Mgat5-/-:Npc1-/- mice. " 11/01/2020 - "The levels of pERK, calbindin, and gliosis markers on the mouse cerebellum at 4-8 weeks old were analyzed to elucidate the correlation among behavioral performance, ERK activation and Purkinje cell degeneration. " 04/01/1999 - "Factor analysis of a set of neuropathological variables revealed two factors; one defined by synaptic density and volume fraction, calbindin pyramidal neuronal densities and viral burden; the second by astrocytosis and calbindin interneuron density. " 04/01/1999 - "To evaluate the specificity of any observed associations, additional variables including viral burden, astrogliosis and number of calbindin-immunoreactive neurons were measured. "
3.	Ischemia 12/01/2007 - "Calbindin levels decreased following ischemia, especially at ZT14. " 05/09/2003 - "We investigated spatial and temporal alterations of calbindin D-28k (CB) immunoreactivity in the gerbil main olfactory bulb after transient ischemia-reperfusion. " 10/11/2002 - "These results suggest that decreased excitability of CA1/CA2 pyramidal cells represents a protective mechanism against ischemia-induced neurodegeneration and might be related to decreased calbindin expression." 10/11/2002 - "In vivo electrophysiological recordings of CA1/CA2 pyramidal cells were performed 10-12 months after global forebrain ischemia (four-vessel occlusion, 15 mm) and were compared to levels of calbindin expression. " 10/11/2002 - "Increased inter-spike intervals and fast after-hyperpolarization of action potentials in rat hippocampal pyramidal cells accompanied with altered calbindin immunoreactivity 10-12 months after global forebrain ischemia."
4.	Parkinson Disease (Parkinson's Disease) 01/01/2019 - "Parkinson disease, substantia nigra vulnerability, and calbindin expression: Enlightening the darkness?" 08/14/2014 - "Current on-going work using a unilateral mouse lesion model of Parkinson's disease shows a greater proportion of calbindin-positive neurons survive the lesion, with intracellular α-syn aggregates almost exclusively occurring in calbindin-negative neurons. " 03/04/2009 - "This heterogeneity is not only important for normal function; calbindin (CB) expression by some dopaminergic SN neurons has been linked with their increased survival in Parkinson's disease. " 08/01/1999 - "We propose that subdivision of the human substantia nigra based on patterns of calbindin immunostaining provides a key tool for analysing the organization of the substantia nigra and offers a new approach to analysing molecular expression patterns in the substantia nigra and the specific patterns of nigral cell degeneration in Parkinson's disease." 01/01/1997 - "In the midbrain, calbindin is preferentially expressed in those dopamine neurons which are spared from degeneration in Parkinson's disease and its animal models. "
5.	Acute Kidney Injury (Acute Renal Failure) 07/01/2022 - "The results of the current study support the combined use of a proximal (Kim-1) and distal tubule (calbindin) marker to phenotype acute kidney injury secondary to cisplatin administration." 08/01/2017 - "Insight into the pathophysiology of acute kidney injury is gleaned from the temporal change markers of renal injury (urine neutrophil gelatinase-associated lipocalin, kidney injury molecule-1, calbindin), followed by a marker of cell cycle arrest (urine insulin-like growth factor-binding protein 7) and, finally, by functional markers of filtration (serum creatinine and cystatin C). " 01/01/2018 - "This minireview highlights several proteins (kidney injury molecule-1, beta-2-microglobulin, neutrophil gelatinase-associated lipocalin, calbindin, monocyte chemotactic protein-1, trefoil factor 3) with the greatest promise for detecting cisplatin-induced acute kidney injury in humans. " 11/01/2012 - "In the present study, we examined the urinary and plasma levels of cystatin C and how useful they are for the early detection of acute kidney injury (AKI) in CDDP-treated rats in comparison with other biomarkers (β2-microglobulin, calbindin, clusterin, EGF, GST-α, GST-μ, KIM-1, NGAL, osteopontin, TIMP-1, and VEGF). "

Related Drugs and Biologics

1.	Calcium-Binding Proteins
2.	Calcium
3.	Parvalbumins
4.	Calbindin 2
5.	Cisplatin (Platino)
6.	Proteins (Proteins, Gene)
7.	Calbindin 1
8.	Cholinergic Agents (Cholinergics)
9.	Lipocalin-2
10.	Trefoil Factor-3

Related Therapies and Procedures

1.	Drug Therapy (Chemotherapy)
2.	Lithotripsy (Extracorporeal Shockwave Lithotripsy)
3.	Injections
4.	Investigational Therapies (Experimental Therapy)
5.	Rhizotomy