Ataxia Telangiectasia Mutated Proteins

A group of PROTEIN SERINE-THREONINE KINASES which activate critical signaling cascades in double strand breaks, APOPTOSIS, and GENOTOXIC STRESS such as ionizing ultraviolet A light, thereby acting as a DNA damage sensor. These proteins play a role in a wide range of signaling mechanisms in cell cycle control.

Also Known As:

Networked: 323 relevant articles (2 outcomes, 25 trials/studies)

Relationship Network

Bio-Agent Context: Research Results

Experts

1.	Lees-Miller, Susan P: 10 articles (07/2021 - 03/2004)
2.	Lavin, Martin F: 8 articles (01/2017 - 01/2003)
3.	Shiloh, Yosef: 6 articles (12/2018 - 10/2005)
4.	Bakkenist, Christopher J: 6 articles (01/2016 - 01/2003)
5.	Foray, Nicolas: 5 articles (01/2022 - 06/2019)
6.	Ye, Ruiqiong: 5 articles (10/2019 - 03/2004)
7.	Gatti, Richard A: 5 articles (01/2017 - 12/2003)
8.	Paull, Tanya T: 5 articles (01/2015 - 10/2010)
9.	Price, Brendan D: 5 articles (01/2012 - 05/2004)
10.	Berthel, Elise: 4 articles (01/2022 - 06/2019)

Related Diseases

1.	Ataxia Telangiectasia (Louis Bar Syndrome) 12/01/2003 - "Improved diagnostic testing for ataxia-telangiectasia by immunoblotting of nuclear lysates for ATM protein expression." 01/01/2021 - "A large number of studies have shown that DNA damage response (DDR) transducer ataxia-telangiectasia mutated (ATM) protein can also be activated by ROS, and its downstream signaling pathway is involved in autophagy regulation. " 10/30/2020 - "A major finding of our study was the intense and highly specific nuclear expression of Ataxia Telangiectasia Mutated (ATM) protein within melanocytes in anagen hair follicle bulbs. " 06/01/2000 - "Previous studies on a limited number of ataxia-telangiectasia (A-T) patients with detectable levels of intracellular ATM protein have suggested a genotype/phenotype correlation. " 06/01/2000 - "Ataxia-telangiectasia: phenotype/genotype studies of ATM protein expression, mutations, and radiosensitivity."
2.	Metabolic Syndrome (Dysmetabolic Syndrome X) 01/01/2013 - "Low-dose hydroxychloroquine (HCQ) and ataxia-telangiectasia-mutated (ATM) protein kinase have recently been postulated to be beneficial for the prevention of the age-associated metabolic syndrome including hypertension, hypercholesterolemia and glucose intolerance; however, the effects of low-dose HCQ on the expression of ATM downstream phosphorylated Akt (protein kinase B) and p53 proteins and cardiomyocyte apoptosis in the peri-infarct myocardium remain unclear. "
3.	Glucose Intolerance 01/01/2013 - "Low-dose hydroxychloroquine (HCQ) and ataxia-telangiectasia-mutated (ATM) protein kinase have recently been postulated to be beneficial for the prevention of the age-associated metabolic syndrome including hypertension, hypercholesterolemia and glucose intolerance; however, the effects of low-dose HCQ on the expression of ATM downstream phosphorylated Akt (protein kinase B) and p53 proteins and cardiomyocyte apoptosis in the peri-infarct myocardium remain unclear. "
4.	Infarction (Infarctions) 01/01/2013 - "Low-dose hydroxychloroquine (HCQ) and ataxia-telangiectasia-mutated (ATM) protein kinase have recently been postulated to be beneficial for the prevention of the age-associated metabolic syndrome including hypertension, hypercholesterolemia and glucose intolerance; however, the effects of low-dose HCQ on the expression of ATM downstream phosphorylated Akt (protein kinase B) and p53 proteins and cardiomyocyte apoptosis in the peri-infarct myocardium remain unclear. "
5.	Hypertension (High Blood Pressure) 01/01/2013 - "Low-dose hydroxychloroquine (HCQ) and ataxia-telangiectasia-mutated (ATM) protein kinase have recently been postulated to be beneficial for the prevention of the age-associated metabolic syndrome including hypertension, hypercholesterolemia and glucose intolerance; however, the effects of low-dose HCQ on the expression of ATM downstream phosphorylated Akt (protein kinase B) and p53 proteins and cardiomyocyte apoptosis in the peri-infarct myocardium remain unclear. "

Related Drugs and Biologics

1.	Phosphotransferases (Kinase)
2.	Proteins (Proteins, Gene)
3.	Proto-Oncogene Proteins c-akt (Protein Kinase B)
4.	Hydroxychloroquine (Plaquenil)
5.	DNA (Deoxyribonucleic Acid)
6.	Histones (Histone)
7.	olaparib
8.	Antisense RNA (Anti-Sense RNA)
9.	Paraffin
10.	Hormones (Hormone)

Related Therapies and Procedures

1.	Radiotherapy
2.	Therapeutics
3.	Adjuvant Chemotherapy
4.	Chinese Traditional Medicine (Traditional Chinese Medicine)
5.	Drug Therapy (Chemotherapy)