N-Terminal Acetyltransferases

Enzymes that catalyze the transfer of an acetyl group, usually from ACETYL COENZYME A, to the N-terminus of a peptide chain.

Also Known As:

Amino-Terminal Amino Acid-Acetylating Enzymes; N-alpha-Acetyltransferases; Peptide N-alpha Acetyltransferase; Peptide N-alpha-Acetyltransferases; Acetyltransferase, N-Terminal; Acetyltransferase, Peptide N-alpha; Acetyltransferases, N-Terminal; Amino Terminal Amino Acid Acetylating Enzyme; Amino Terminal Amino Acid Acetylating Enzymes; N Terminal Acetyltransferase; N Terminal Acetyltransferases; N alpha Acetyltransferase; N alpha Acetyltransferases; N-alpha Acetyltransferase, Peptide; N-alpha-Acetyltransferases, Peptide; Peptide N alpha Acetyltransferase; Peptide N alpha Acetyltransferases; Amino-Terminal Amino Acid-Acetylating Enzyme; N-Terminal Acetyltransferase; N-alpha-Acetyltransferase

Networked: 17 relevant articles (0 outcomes, 2 trials/studies)

Bio-Agent Context: Research Results

Enzymes and Coenzymes: 1
- Enzymes: 152586
  - Transferases: 6589
    - Acyltransferases: 374
      - Acetyltransferases: 1040
        N-Terminal Acetyltransferases: 17
        N-Terminal Acetyltransferase B: 1
        C elegans DAF-31 protein
        human NAT10 protein
        mouse Nat10 protein
        N-Terminal Acetyltransferase A
        N-Terminal Acetyltransferase C
        N-Terminal Acetyltransferase D
        N-Terminal Acetyltransferase E
        N-Terminal Acetyltransferase F
        rat N-alpha-acetyltransferase 10

Experts

1.	Arnesen, Thomas: 6 articles (12/2016 - 04/2006)
2.	Kirmizis, Antonis: 3 articles (01/2021 - 03/2016)
3.	Koufaris, Costas: 2 articles (01/2021 - 09/2020)
4.	Blenski, Marina: 2 articles (01/2016 - 11/2015)
5.	Støve, Svein I: 2 articles (11/2015 - 04/2015)
6.	Ahmed, Farjana: 1 article (01/2021)
7.	Husain, Matloob: 1 article (01/2021)
8.	AlDubayee, Mohammed: 1 article (01/2019)
9.	Alammari, Nawaf: 1 article (01/2019)
10.	Aljada, Ahmad: 1 article (01/2019)

Related Diseases

1.	Neoplasms (Cancer) 09/15/2020 - "N-Terminal Acetyltransferases Are Cancer-Essential Genes Prevalently Upregulated in Tumours." 03/01/2016 - "This modification is catalysed by evolutionarily conserved N-terminal acetyltransferases (NATs) whose deregulation has been linked to cancer development and thus, are emerging as useful diagnostic and therapeutic targets. " 01/17/2013 - "Protein N-terminal acetyltransferases in cancer." 01/01/2015 - "N-terminal acetyltransferases are recognized to play important roles in a diversity of cellular processes like apoptosis, cell proliferation, sister chromatid cohesion, and chromatin silencing and are even linked to the development of rare genetic disorders and cancer. " 01/01/2021 - "In this study we initially interrogated the Cancer Genome Atlas (TCGA) dataset to determine the implication of N-terminal acetyltransferases (NATs), a family of enzymes that modify the N-terminus of the majority of eukaryotic proteins, in LIHC. "
2.	Carcinogenesis 12/11/2008 - "Implication of human N-alpha-acetyltransferase 5 in cellular proliferation and carcinogenesis." 08/01/2010 - "Previous studies on human N-alpha-acetyltransferase 10, NatA catalytic subunit (hNaa10p; also known as human arrest-defective 1 [hARD1]), have generated conflicting results with regard to its role in tumorigenesis. " 01/01/2011 - "Human arrest defective 1 protein (ARD1), as a N-terminal acetyltransferase, has been reported to play a crucial role in tumorigenesis, but the results are somewhat controversial. "
3.	Inborn Genetic Diseases (Disease, Hereditary) 04/01/2015 - "The X-linked lethal Ogden syndrome was the first reported human genetic disorder associated with a mutation in an N-terminal acetyltransferase (NAT) gene. " 01/01/2015 - "N-terminal acetyltransferases are recognized to play important roles in a diversity of cellular processes like apoptosis, cell proliferation, sister chromatid cohesion, and chromatin silencing and are even linked to the development of rare genetic disorders and cancer. "
4.	Intellectual Disability (Idiocy) 11/02/2015 - "NAA10 mutation causing a novel intellectual disability syndrome with Long QT due to N-terminal acetyltransferase impairment." 01/01/2016 - "The core phenotype of X-linked NAA10-related N-terminal-acetyltransferase deficiency in both males and females includes developmental delay, severe intellectual disability, postnatal growth failure with severe microcephaly, and skeletal or cardiac anomalies. "
5.	Disease Resistance 01/01/2023 - "We further validated AP2-like ethylene-responsive transcription factor, N-alpha-acetyltransferase (NatA), cytochrome P450, amidase family protein, tetratricopeptide repeat, bHLH transcription factor, and disease resistance protein RGA2-like using PCR allelic competitive extension (PACE) genotyping. "

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