Polycomb-Group Proteins

A family of proteins that play a role in CHROMATIN REMODELING. They are best known for silencing HOX GENES and the regulation of EPIGENETIC PROCESSES.

Also Known As:

PRC1-Like Complex; PcG Complex Proteins; Polycomb Group (PcG) Multiprotein PRC1-Like Complex; Polycomb Repressive Complex Proteins; Polycomb-Group Protein Complexes; Complex Protein, PcG; Complex, PRC1-Like; Complex, Polycomb-Group Protein; Complexes, Polycomb-Group Protein; Group Protein, Polycomb; PRC1 Like Complex; Polycomb Group Protein Complex; Polycomb Group Protein Complexes; Polycomb Group Proteins; Protein Complex, Polycomb-Group; Protein Complexes, Polycomb-Group; Protein, PcG Complex; Protein, Polycomb Group; Protein, Polycomb-Group; PcG Complex Protein; Polycomb Group Protein; Polycomb Repressive Complex Protein; Polycomb-Group Protein; Polycomb-Group Protein Complex

Networked: 225 relevant articles (1 outcomes, 9 trials/studies)

Relationship Network

Bio-Agent Context: Research Results

Experts

1.	Kleer, Celina G: 9 articles (01/2021 - 09/2003)
2.	Nakanuma, Yasuni: 6 articles (03/2015 - 08/2008)
3.	Sasaki, Motoko: 6 articles (03/2015 - 08/2008)
4.	Chinnaiyan, Arul M: 5 articles (01/2019 - 10/2002)
5.	Cao, Qi: 4 articles (10/2020 - 09/2003)
6.	Dimri, Goberdhan P: 4 articles (06/2016 - 04/2011)
7.	Dimri, Manjari: 4 articles (06/2016 - 04/2011)
8.	Harada, Mamoru: 4 articles (05/2015 - 09/2004)
9.	Pasini, Diego: 4 articles (05/2015 - 04/2004)
10.	Ikeda, Hiroko: 4 articles (02/2010 - 08/2008)

Related Diseases

1.	Breast Neoplasms (Breast Cancer) 01/01/2021 - "Noncanonical Functions of the Polycomb Group Protein EZH2 in Breast Cancer." 04/30/2014 - "The Polycomb group protein RING1B is overexpressed in ductal breast carcinoma and is required to sustain FAK steady state levels in breast cancer epithelial cells." 04/01/2013 - "EZH2 is a Polycomb group protein that exerts oncogenic functions in breast cancer, where its overexpression is associated with metastatic disease. " 01/01/2011 - "The polycomb group protein enhancer of zeste homologue 2 (EZH 2) has been reported as a marker of aggressive breast cancer. " 09/01/2006 - "The Polycomb group protein Enhancer of Zeste 2: its links to DNA repair and breast cancer."
2.	Lymphoma (Lymphomas) 10/01/2012 - "Articles regarding the mechanism of EZH2 in post-transcriptional modification, functions of polycomb group proteins, and the roles of EZH2 in lymphoma were selected. " 11/01/2017 - "UBAP2L interacts with the Polycomb group protein B lymphoma Mo-MLV insertion region 1 homolog (BMI1) and determines the activity of mouse hematopoietic stem cells in vivo Here we show that loss of Ubap2l leads to disorganized respiratory epithelium of mutant neonates, which die of respiratory failure. " 08/28/2015 - "Bmi1, the polycomb group protein B lymphoma Mo-MLV insertion region 1 homolog, regulates EMT transition, maintains the self-renewal capacity of stem cells, and is frequently overexpressed in human cancers. " 10/01/2012 - "enhancer of zeste homologue 2 (EZH2) and B lymphoma Mo-MLV insertion region 1 homolog (BMI-1) are the best-characterized polycomb group proteins; their deregulation contributes to the development of many malignancies including gastric cancers. " 12/01/2009 - "The polycomb group protein B lymphoma Mo-MLV insertion region 1 homolog (Bmi-1) is dysregulated in various cancers, and its upregulation strongly correlates with an invasive phenotype and poor prognosis in patients with nasopharyngeal carcinomas. "
3.	Neoplasms (Cancer) 11/03/2022 - "Polycomb group proteins are often dysregulated in cancer, leading to disruption of epigenetic landscapes and acquisition of cancer hallmarks. " 01/01/2022 - "Mechanisms of Polycomb group protein function in cancer." 12/01/2021 - "Polycomb group proteins in cancer: multifaceted functions and strategies for modulation." 04/01/2021 - "Structural assembly of Polycomb group protein and Insight of EZH2 in cancer progression: A review." 01/01/2021 - "Polycomb-group proteins in the initiation and progression of cancer."
4.	Carcinogenesis 05/10/2010 - "Integrating genomic data with functional studies in multiple cell lines, we demonstrated that ERG and ESE3 controlled in opposite direction transcription of the Polycomb Group protein EZH2, a key gene in development, differentiation, stem cell biology and tumorigenesis. " 01/01/2014 - "Polycomb group proteins (PcGs) are transcriptional repressors involved in physiological processes whereas PcG deregulation might result in oncogenesis. " 11/01/2008 - "We report here that the polycomb group protein Bmi1 promotes prostate tumorigenesis. " 02/01/2008 - "Inactivation of the polycomb group protein Ring1B unveils an antiproliferative role in hematopoietic cell expansion and cooperation with tumorigenesis associated with Ink4a deletion." 06/01/2007 - "Our results demonstrate that the direct targeting of Polycomb group proteins by an oncogene plays a key role during carcinogenesis."
5.	Stomach Neoplasms (Stomach Cancer) 01/01/2018 - "The polycomb group protein EZH2 induces epithelial-mesenchymal transition and pluripotent phenotype of gastric cancer cells by binding to PTEN promoter." 10/01/2012 - "Immunohistochemical analysis of polycomb group protein expression in advanced gastric cancer." 09/27/2016 - "Mel-18, a polycomb group protein, has been reported to act as a tumor suppressor and be down-regulated in several human cancers including gastric cancer. " 05/10/2015 - "Further experiments revealed that Polycomb group protein enhancer of zeste homolog 2 (EZH2) was a direct target of miR-217 in gastric cancer cells. " 10/01/2012 - "enhancer of zeste homologue 2 (EZH2) and B lymphoma Mo-MLV insertion region 1 homolog (BMI-1) are the best-characterized polycomb group proteins; their deregulation contributes to the development of many malignancies including gastric cancers. "

Related Drugs and Biologics

1.	Proteins (Proteins, Gene)
2.	Enhancer of Zeste Homolog 2 Protein
3.	Lysine (L-Lysine)
4.	Long Noncoding RNA
5.	Transcription Factors (Transcription Factor)
6.	Tretinoin (Retinoic Acid)
7.	DNA Methyltransferase 3B
8.	Chromatin
9.	Peptides (Polypeptides)
10.	Methyltransferases

Related Therapies and Procedures

1.	Therapeutics
2.	Immunotherapy
3.	Drug Therapy (Chemotherapy)