rho Guanine Nucleotide Dissociation Inhibitor alpha

An abundantly-expressed rho GDP-dissociation inhibitor subtype that regulates a broad variety of RHO GTPASES.

Also Known As:

rho GDIalpha; rho GDP Dissociation Inhibitor (GDI) alpha; rho GDP-Dissociation Inhibitor 1; rho Guanine Nucleotide Dissociation Inhibitor 1; rhoGDI1; rhoGDIalpha; rho GDP Dissociation Inhibitor 1

Networked: 35 relevant articles (0 outcomes, 3 trials/studies)

Bio-Agent Context: Research Results

Amino Acids, Peptides, and Proteins: 1
- Proteins: 484843
  - Intracellular Signaling Peptides and Proteins: 32
    - GTP-Binding Protein Regulators
      - Guanine Nucleotide Dissociation Inhibitors: 97
        rho-Specific Guanine Nucleotide Dissociation Inhibitors: 55
        rho Guanine Nucleotide Dissociation Inhibitor alpha: 35
        human ARHGDIA protein
        mouse Arhgdia protein
- Peptides: 82426
  - Intracellular Signaling Peptides and Proteins: 32
    - GTP-Binding Protein Regulators
      - Guanine Nucleotide Dissociation Inhibitors: 97
        rho-Specific Guanine Nucleotide Dissociation Inhibitors: 55
        rho Guanine Nucleotide Dissociation Inhibitor alpha: 35
        human ARHGDIA protein
        mouse Arhgdia protein

Experts

1.	Yao, Wenjuan: 2 articles (09/2021 - 07/2019)
2.	Jin, Feng: 1 article (09/2022)
3.	Song, Guiyu: 1 article (09/2022)
4.	Guan, Haijing: 1 article (09/2021)
5.	Liang, Xiuying: 1 article (09/2021)
6.	Qi, Yan: 1 article (09/2021)
7.	Sun, Jingwen: 1 article (09/2021)
8.	Chen, Yi: 1 article (07/2021)
9.	Guo, Shuliang: 1 article (07/2021)
10.	Huang, Guichuan: 1 article (07/2021)

Related Diseases

1.	Neoplasms (Cancer) 01/01/2018 - "Our study connects the interaction between RhoGDI1 and ephrinB1 to the promotion of cancer cell behavior associated with tumor progression. " 01/01/2018 - "Collectively, these results indicate that PPM1B negatively regulates cancer cell motility and invasiveness through dephosphorylating RhoGDI1." 01/01/2018 - "EphrinB1 promotes cancer cell migration and invasion through the interaction with RhoGDI1." 03/01/2007 - "RhoGDIalpha has been shown to be overexpressed in multiple types of tumors such as ovarian and breast cancer. " 08/01/2017 - "In vitro studies involving the silencing of RhoGDI1 or RhoGDI2 demonstrated a significant increase in the migratory and invasive ability of tumor cells upon the silencing of these genes. "
2.	Neointima 09/06/2021 - "This study revealed the novel mechanism by which RhoGDI1 stability promotes the RhoGDI1-Cdc42 interaction and Cdc42 activation, thereby affecting VSMC phenotypic transformation and neointima formation." 09/06/2021 - "In the present study, we investigated the regulatory effect of RhoGDI1 on the activation of RhoGTPase in VSMC transformation and neointima formation. " 09/06/2021 - "In addition, RhoGDI1 knockdown significantly inhibited VSMC phenotypic transformation and neointima formation in vitro and in vivo. "
3.	Breast Neoplasms (Breast Cancer) 02/01/2010 - "There is evidence, that Rho-GDIalpha may modulate drug resistance of breast cancer cells. " 03/01/2007 - "RhoGDIalpha has been shown to be overexpressed in multiple types of tumors such as ovarian and breast cancer. " 02/01/2010 - "Rho-GDIalpha is possibly a useful biomarker to predict the response of breast cancer patients to CMF treatment." 01/01/2018 - "In contrast, knockdown of PPM1B in MCF-7 and MDA-MB-468 human breast cancer cells that express endogenous PPM1B enhances EGF-induced RhoGDI1 phosphorylation, activation of Rho GTPases, and cancer cell migration and invasion. " 02/01/2010 - "To assess the importance of Rho-GDIalpha as a risk factor in invasive ductal breast cancer, cancer specimens of three groups of patients were analyzed for Rho-GDIalpha RNA (group 1, N=72 and group 2, N=73) or protein expression (group 3, N=90). "
4.	Vascular Remodeling 02/01/2008 - "These results demonstrate that vascular remodeling results in significant alterations in the protein expression profile of the aorta during hypertension and suggest that the upregulation of RhoGDIalpha in hypertension is induced by Ang II via AT(1) receptor." 07/01/2019 - "Fasudil treatment reduced the expression of TGFβ1, RhoGDI1, and RhoGDI2 in addition to vascular remodeling in the rat balloon injury model. "
5.	Neurodegenerative Diseases (Neurodegenerative Disease) 01/01/2014 - "We found that: (1) proteins involved in brain-specific function (Ncald, Nrgn, Stmn1, Stmn2), antioxidant defenses (Aop1), cell cycle (RhoGDI1, Ran), and cytoskeleton assembly (Tbcb, CapZa2) were differentially expressed in brains of Blmh-null mice; (2) hyperhomocysteinemia amplified effects of the Blmh-/- genotype on brain protein expression; (3) proteins involved in brain-specific function (Pebp1), antioxidant defenses (Sod1, Prdx2, DJ-1), energy metabolism (Atp5d, Ak1, Pgam-B), and iron metabolism (Fth) showed differential expression in Blmh-null brains only in hyperhomocysteinemic animals; (4) most proteins regulated by the Blmh-/- genotype were also regulated by high-Met diet, albeit in the opposite direction; and (5) the differentially expressed proteins play important roles in neural development, learning, plasticity, and aging and are linked to neurodegenerative diseases, including AD. " 03/23/2021 - "Besides, proteins related to neuropathology, such as excitatory amino acid transporter 2, calcium/calmodulin-dependent protein kinase type II subunit alpha, and Cu-Zn superoxide dismutase were found only in the group of aged wild-type mice; 4-aminobutyrate amino transferase, limbic system-associated membrane protein, sodium- and chloride-dependent GABA transporter 3 and ProSAAS were found only in the group of young GNMT-KO mice and are related to function of neurons; serum albumin and Rho GDP dissociation inhibitor 1 were found only in the group of aged GNMT-KO mice and are connected to neurodegenerative disorders. "

Related Drugs and Biologics

1.	rho Guanine Nucleotide Dissociation Inhibitor beta
2.	Proteins (Proteins, Gene)
3.	rho GTP-Binding Proteins (rho GTP-Binding Protein)
4.	rho-Specific Guanine Nucleotide Dissociation Inhibitors
5.	Guanine Nucleotide Dissociation Inhibitors (GDIs)
6.	GTP Phosphohydrolases (GTPases)
7.	Integrins
8.	Biomarkers (Surrogate Marker)
9.	Hippocalcin
10.	Catenins