Buschke-Lowenstein Tumor

Exophytic tumor of the anogenital region associated with HPV infections. It becomes a large cauliflower-like, hyperkeratotic, verrucous mass that is locally destructive with little atypical cells. Histologically, tumor cells are broad rete peg structures that tend to invade deeper than CONDYLOMATA ACUMINATA.

Also Known As:

Anogenital Type Verrucous Carcinoma; Buschke Lowenstein Tumor; Buschke Löwenstein Tumor; Giant Condyloma Acuminatum; Giant Condyloma of Buschke and Lowenstein; Giant Condyloma of Buschke and Löwenstein; Condyloma Acuminatum, Giant; Condyloma Acuminatums, Giant; Giant Condyloma Acuminatums; Lowenstein Tumor, Buschke; Löwenstein Tumor, Buschke; Tumor, Buschke Lowenstein; Tumor, Buschke Löwenstein; Tumor, Buschke-Lowenstein; Tumor, Buschke-Löwenstein; Buschke-Löwenstein Tumor

Networked: 53 relevant articles (3 outcomes, 0 trials/studies)

Relationship Network

Disease Context: Research Results

Related Diseases

1.	Buschke-Lowenstein Tumor
2.	Verrucous Carcinoma
3.	Neoplasms (Cancer)
4.	Squamous Cell Carcinoma (Epidermoid Carcinoma)
5.	Acquired Immunodeficiency Syndrome (AIDS)

Experts

1.	Decker, Ashley: 1 article (06/2022)
2.	Fawaz, Bilal: 1 article (06/2022)
3.	Lawrence, Naomi: 1 article (06/2022)
4.	Vieira, Carlos: 1 article (06/2022)
5.	Ankouane Andoulo, Firmin: 1 article (03/2022)
6.	Atangana, Paul Jean Adrien: 1 article (03/2022)
7.	Kouotou, Emmanuel Armand: 1 article (03/2022)
8.	Kowo, Mathurin: 1 article (03/2022)
9.	Nzoume Nsope Mengang, Jude-Marcel: 1 article (03/2022)
10.	Simeni Njonnou, Sylvain Raoul: 1 article (03/2022)

Drugs and Biologics

Drugs and Important Biological Agents (IBA) related to Buschke-Lowenstein Tumor:

1.	Acitretin FDA Link 10/01/2017 - "Recalcitrant giant condyloma acuminatum treated successfully with a novel combination of Mycobacterium indicus pranii immunotherapy and acitretin." 01/01/2021 - "A case of giant condyloma acuminatum (Buschke-Lowenstein tumor) successfully treated with acitretin." 11/01/2020 - "Combination of oral acitretin, antiretroviral therapy, human papillomavirus vaccine, and carbon dioxide laser ablation for the treatment of giant condyloma acuminatum of the vulva in a patient with AIDS."
2.	Imiquimod (Aldara)FDA LinkGeneric 12/01/2020 - "Complete healing of perianal giant condyloma (buschke-löwenstein tumor) with imiquimod 5% cream alone." 10/01/2019 - "Successful nonsurgical treatment of penile Buschke-Löwenstein tumor with 12 weeks of 5% imiquimod alone." 08/01/2018 - "Giant condyloma acuminatum of the vulva: Successful management with imiquimod." 11/01/2015 - "Successful treatment with topical imiquimod of anal Buschke-Löwenstein tumor in a child." 01/01/2021 - "Successful combined treatment of Buschke-Lowenstein tumor in anal canal with electroresection, photodynamic therapy and topical 5% imiquimod."
3.	PodophyllinIBA 03/18/2022 - "The diagnosis of Buschke-Löwenstein tumor was made on mass biopsy, and the patient underwent multidisciplinary intervention (surgery, podophyllin application, and antiretroviral therapy). " 04/01/2015 - "Electrocautery resection, shaving with a scalpel, and podophyllin: a combination therapy for giant condyloma acuminatum." 01/01/1950 - "[Giant condyloma acuminatum, phimosis, perforation of the prepuce, treated with podophyllin]."
4.	Interferon-alpha (Interferon Alfa)IBA 06/01/2000 - "Regression of deeply infiltrating giant condyloma (Buschke-Löwenstein tumor) following long-term intralesional interferon alfa therapy." 01/01/1992 - "[Combination therapy of Buschke-Löwenstein tumor with CO2 laser and interferon-alpha]."
5.	Papillomavirus Vaccines (HPV Vaccines)IBA 11/01/2020 - "Combination of oral acitretin, antiretroviral therapy, human papillomavirus vaccine, and carbon dioxide laser ablation for the treatment of giant condyloma acuminatum of the vulva in a patient with AIDS."
6.	Telomerase (Telomerase Reverse Transcriptase)IBA 01/01/2000 - "To our knowledge, this is the first case of telomerase activity in giant condyloma acuminatum ever reported. " 01/01/2000 - "Telomerase activity in giant condyloma acuminatum." 01/01/2000 - "In addition to the histological examination, measurement of telomerase activity may provide valuable objective diagnostic information on evaluating the degree of malignancy of giant condyloma acuminatum and in obtaining a differential diagnosis between the benign and malignant."
7.	SteroidsIBA 11/01/2023 - "Sex Steroid Modulators and the Development of Buschke-Lowenstein Tumor: A Case Report of an Immunocompetent Patient."
8.	Rubella VaccineIBA 01/01/2022 - "Buschke-Lowenstein tumor treated with intralesional measles, mumps, and rubella vaccine."
9.	RetinoidsIBA 06/01/2012 - "Successful treatment of giant condyloma acuminatum with combination retinoid and interferon-γ therapy."
10.	Interleukin-2 (IL2)IBA 09/01/2013 - "Successful treatment of perianal giant condyloma acuminatum in an immunocompromised host with systemic interleukin 2 and topical cidofovir."

Therapies and Procedures

1.	Immunotherapy 03/01/1982 - "Condylomata were successfully eradicated in 94.1 per cent of patients, which indicates that immunotherapy is a very effective alternative in the treatment of recurrent and giant condyloma acuminatum." 03/01/1982 - "Immunotherapy was used on 17 patients with recurrent and giant condyloma acuminatum. " 10/01/2017 - "Recalcitrant giant condyloma acuminatum treated successfully with a novel combination of Mycobacterium indicus pranii immunotherapy and acitretin."
2.	Induced Hyperthermia (Thermotherapy) 02/11/2021 - "Giant Condyloma Acuminatum Treated Successfully with Mild Local Hyperthermia: Two Case Reports."
3.	Therapeutics 01/01/2019 - "Recalcitrant extragenital giant condyloma acuminatum: A need for combination therapy." 01/01/2007 - "Operative therapy of a monstrous Buschke-Löwenstein tumor." 03/01/2004 - "Perianal giant condyloma acuminatum is a rare variant of condyloma acuminata and its therapy often proves distinctly challenging. " 02/01/2000 - "We report a case of a highly recurrent giant perianal condyloma, or Buschke-Lowenstein tumor, which was successfully treated by telecobalt therapy. " 01/01/2009 - "Successful surgical management of giant condyloma acuminatum (Buschke-Löwenstein tumor) in the genitoanal region: a case report and evaluation of current therapies."
4.	Gas Lasers 12/27/2008 - "Treatment with CO2 laser in combination with conservative surgery may be a therapeutic option in Buschke-Lowenstein tumor." 03/01/2002 - "After a review of the literature, three cases of giant condyloma acuminatum, treated by combined CO2 Laser surgery excision-vaporization and which underwent a long-term follow-up are described." 07/01/1987 - "[CO2 laser treatment of the Buschke-Löwenstein tumor]." 03/01/2002 - "Giant condyloma acuminatum or buschke-Lowenstein tumor: review of the literature and report of three cases treated by CO2 laser surgery. " 01/01/1992 - "[Combination therapy of Buschke-Löwenstein tumor with CO2 laser and interferon-alpha]."
5.	Drug Therapy (Chemotherapy) 11/01/1993 - "Buschke-Lowenstein tumor: therapeutic options including systemic chemotherapy." 04/01/2010 - "Successful treatment of recurrent Buschke-Lowenstein tumor by radiation therapy and chemotherapy." 01/01/2020 - "We present a case of giant condyloma acuminatum (Buschke-Lowestein tumor) managed with combined treatment of surgery of chemotherapy." 01/01/2020 - ""Giant Condyloma Acuminatum (Buschke-Lowenstein tumor): Combined treatment with surgery and chemotherapy."-Further points to be discussed." 01/01/2020 - "Giant condyloma acuminatum (Buschke-Lowenstein tumor): Combined treatment with surgery and chemotherapy."