Steatocystoma Multiplex

A disorder characterized by multiple, wide spread cutaneous cysts that often become inflamed and rupture. It is caused by the same mutations in the gene coding for KRT-17 that are causative mutations for Pachyonychia congenita, Type 2. Natal teeth involvement is sometimes associated with steatocystoma multiplex.

Also Known As:

Multiple Sebaceous Cysts; Multiplex Steatocystoma; Sebaceous Cysts, Multiple; Cyst, Multiple Sebaceous; Cysts, Multiple Sebaceous; Multiple Sebaceous Cyst; Multiplex Steatocystomas; Sebaceous Cyst, Multiple; Steatocystoma Multiplices; Steatocystoma, Multiplex; Steatocystomas, Multiplex

Networked: 49 relevant articles (1 outcomes, 3 trials/studies)

Relationship Network

Disease Context: Research Results

Related Diseases

1.	Adenocarcinoma of Lung
2.	Cysts
3.	Epidermal Cyst (Sebaceous Cyst)
4.	Trichofolliculoma
5.	Pachyonychia Congenita (Jadassohn-Lewandowsky Syndrome)

Experts

1.	Ahmed, Ghazal: 1 article (09/2021)
2.	Ganguly, Satyaki: 1 article (09/2021)
3.	Prabha, Neel: 1 article (09/2021)
4.	Chen, Xiaogang: 1 article (01/2021)
5.	Chen, Yuchong: 1 article (01/2021)
6.	Cheng, Chun-Yu: 1 article (01/2021)
7.	Jiang, Long: 1 article (01/2021)
8.	Tang, Yichen: 1 article (01/2021)
9.	Yan, Jianna: 1 article (01/2021)
10.	Cinelli, Eleonora: 1 article (09/2020)

Drugs and Biologics

Drugs and Important Biological Agents (IBA) related to Steatocystoma Multiplex:

1.	Gefitinib (Iressa)FDA Link 02/01/2014 - "We describe a 56-year-old lung adenocarcinoma patient, initially diagnosed with steatocystoma multiplex who responded well to gefitinib treatment. " 02/01/2014 - "Steatocystoma multiplex as initial impression of non-small cell lung cancer with complete response to gefitinib."
2.	Keratin-17 (Keratin 17)IBA 05/10/2001 - "To study the relationship between steatocystoma multiplex (SCM) and keratin 17 gene mutation. " 12/01/2019 - "One type of steatocystoma multiplex is known to be associated with the autosomal dominant inheritance of a mutation in the gene coding for keratin 17 (KRT17). " 11/01/2013 - "A novel missense mutation of keratin 17 gene in a chinese family with steatocystoma multiplex." 12/01/2012 - "Steatocystoma multiplex: keratin 17 - the key player?" 01/01/2011 - "A novel mutation (p.Arg94Gly) of keratin 17 in a Chinese family with steatocystoma multiplex."
3.	Advanced Glycation End ProductsIBA 01/01/2004 - "Immunohistochemical studies using monoclonal anti-AGE (advanced glycation end product) antibody demonstrated that keratinous materials within the cystic structures were immunoreactive to the antibody, whereas those of cystic lesions (epidermal cyst, eruptive vellus hair cyst, steatocystoma multiplex, trichofolliculoma and trichilemmal cyst) seen in otherwise healthy individuals were negative. "
4.	Rifampin (Rifampicin)FDA LinkGeneric 09/01/2021 - "Familial Steatocystoma Multiplex Generalisita Suppuritiva: Oral Rifampicin and Clindamycin Combination Worth a Trial."
5.	Clindamycin (Cleocin)FDA LinkGeneric 09/01/2021 - "Familial Steatocystoma Multiplex Generalisita Suppuritiva: Oral Rifampicin and Clindamycin Combination Worth a Trial."
6.	Isotretinoin (Accutane)FDA LinkGeneric 11/01/1988 - "A small number of patients with steatocystoma multiplex have been treated with isotretinoin, with varied responses. " 11/01/1988 - "Isotretinoin may show a beneficial response in some cases of steatocystoma multiplex even after use of the drug is discontinued. " 11/01/1988 - "A patient with steatocystoma multiplex was treated with 0.75 mg per kg per day of oral isotretinoin. " 11/01/1988 - "Steatocystoma multiplex treated with isotretinoin: a delayed response." 06/01/1987 - "Consistent with findings from previous reports, treatment with isotretinoin should be reserved for patients with steatocystoma multiplex suppurativum."
7.	Keratins (Keratin)IBA 06/01/2009 - "Novel missense mutation of keratin in Chinese family with steatocystoma multiplex." 03/01/2002 - "Cytokeratin expression in steatocystoma multiplex." 06/01/2002 - "Given that identical inherited mutations in this gene can cause either pachyonychia congenita or steatocystoma multiplex, the features of this mouse model suggest that this clinical heterogeneity arises from a cell type-specific, genetically determined compensation by related keratins." 06/01/1997 - "Expression of keratins (K10 and K17) in steatocystoma multiplex, eruptive vellus hair cysts, and epidermoid and trichilemmal cysts." 01/01/1997 - "A family with affected members, previously reported to carry an R94H mutation of keratin K17, and characterized by a variable and oligosymptomatic form of pachyonychia congenita of the Jackson-Sertoli type with steatocystoma multiplex, is described in detail."
8.	Calbindin 2IBA 06/01/2008 - "Late onset of a facial variant of steatocystoma multiplex - calretinin as a specific marker of the follicular companion cell layer."
9.	Keratin-10IBA 06/01/1997 - "We compared the patterns of keratin 10 (K10) and keratin 17 (K17) expression in epidermoid cysts, trichilemmal cysts, eruptive vellus hair cysts, and steatocystoma multiplex. "
10.	Interleukin-12 (IL 12)IBA 09/01/2020 - "A Case of Steatocystoma Multiplex in a Psoriatic Patient during Treatment with Anti-IL-12/23."

Therapies and Procedures

1.	Gas Lasers 07/01/2020 - "The rationale of ideal pulse duration and pulse interval in the treatment of steatocystoma multiplex using the carbon dioxide laser in a super-pulse mode as opposed to the ultra-pulse mode." 11/01/2016 - "Fractionated ablative carbon dioxide laser treatment of steatocystoma multiplex." 06/01/2014 - "Carbon dioxide laser perforation and extirpation of steatocystoma multiplex." 04/01/2003 - "We consider CO2 laser therapy to be an ideal technique for the treatment of steatocystoma multiplex, especially when the lesions are localized in aesthetically important areas." 04/01/2003 - "CO2 laser therapy in a case of steatocystoma multiplex with prominent nodules on the face and neck."
2.	Therapeutics 01/01/1993 - "Aspiration therapy in steatocystoma multiplex." 07/01/2010 - "Er: yag laser therapy for steatocystoma multiplex." 04/01/2003 - "We consider CO2 laser therapy to be an ideal technique for the treatment of steatocystoma multiplex, especially when the lesions are localized in aesthetically important areas." 04/01/2003 - "CO2 laser therapy in a case of steatocystoma multiplex with prominent nodules on the face and neck." 01/01/1991 - "CO2 laser therapy for steatocystoma multiplex."
3.	Semiconductor Lasers 10/01/2019 - "1927-nm fiber-optic diode laser: A novel therapeutic option for facial steatocystoma multiplex." 07/01/2012 - "1,450-nm diode laser in combination with the 1550-nm fractionated erbium-doped fiber laser for the treatment of steatocystoma multiplex: a case report." 07/01/2012 - "Herein, we present the case of a patient with isolated steatocystoma multiplex on the abdomen and lower chest with substantial clearance after two laser treatment sessions using two complementary lasers: a 1,450-nm diode laser to target the abnormal sebaceous glands and a 1,550-nm fractionated erbium-doped fiber laser to target the dermal cysts."
4.	Cryotherapy (Therapy, Cold) 01/01/2021 - "Ultrasound-Guided Intralesional Cryotherapy for Treatment of Steatocystoma Multiplex." 05/01/2000 - "Steatocystoma multiplex suppurativum: oral isotretinoin treatment combined with cryotherapy."
5.	Solid-State Lasers 07/01/2010 - "Er: yag laser therapy for steatocystoma multiplex."