Acid Sensing Ion Channel Blockers

A subclass of sodium channel blockers that are specific for ACID-SENSING SODIUM CHANNELS.

Also Known As:

ASIC Blockers; ASIC Channel Antagonists; ASIC Channel Blockers; ASIC Inhibitors; Acid Sensing Ion Channel Inhibitors; Antagonists, ASIC Channel; Blockers, ASIC Channel; Channel Antagonists, ASIC; Channel Blockers, ASIC; Proton Gated Sodium Channel Blockers; Proton-Gated Sodium Channel Blockers

Networked: 11 relevant articles (1 outcomes, 1 trials/studies)

Relationship Network

Bio-Agent Context: Research Results

Chemical Actions and Uses
- Pharmacologic Actions: 160
  - Molecular Mechanisms of Pharmacological Action: 24
    - Membrane Transport Modulators
      - Sodium Channel Blockers: 584
        Acid Sensing Ion Channel Blockers: 11

Experts

1.	MacDonald, John F: 2 articles (12/2010 - 09/2004)
2.	Mango, Dalila: 1 article (01/2021)
3.	Nisticò, Robert: 1 article (01/2021)
4.	Kellenberger, Stephan: 1 article (01/2020)
5.	Vullo, Sabrina: 1 article (01/2020)
6.	Al-Saad, Houssam: 1 article (03/2019)
7.	Dibas, Adnan: 1 article (03/2019)
8.	Dibas, Jamileh: 1 article (03/2019)
9.	Valade, Dominique: 1 article (01/2019)
10.	Anangi, Raveendra: 1 article (01/2018)

Related Diseases

1.	Migraine Disorders (Migraine) 07/01/2015 - "Although few studies have directly examined a role of ASICs in migraine, studies directly examining a connection have generated promising results including efficacy of ASIC blockers in both preclinical migraine models and in human migraine patients. " 01/01/2019 - "In addition, other promising drugs for the treatment of migraine are nitric oxide synthase inhibitors and acid-sensing ion channel (ASIC) blockers."
2.	Pain (Aches) 12/09/2011 - "The results also indicate caution in the use of AMI for studying ASIC physiology and in the development of AMI-derived ASIC inhibitors for treating pain syndromes." 01/01/2018 - "Diminazene and APETx2 are moderately potent ASIC inhibitors, both inducing peripheral antihyperalgesia in a rat model of chronic inflammatory pain. " 01/01/2023 - "ASIC inhibitors reduce peripheral acid-induced hyperalgesia and suppress inflammatory pain. "
3.	Neurodegenerative Diseases (Neurodegenerative Disease) 01/01/2021 - "On this basis, acid-sensing ion channel blockers are able to exert neuroprotective effects in different neurodegenerative diseases. " 03/01/2019 - "Also, the ability of acid-sensing ion channel blockers to exert neuroprotective effects in a number of neurodegenerative diseases has added a new dimension to their therapeutic value. "
4.	Acidosis 01/01/2023 - "These effects of acidosis on Ca2+ oscillations were not blocked by NS383 and amiloride [acid-sensing ion channel (ASIC) inhibitors]. " 09/17/2004 - "Here, we show that acidosis activates Ca2+ -permeable acid-sensing ion channels (ASICs), inducing glutamate receptor-independent, Ca2+ -dependent, neuronal injury inhibited by ASIC blockers. "
5.	Nervous System Diseases (Neurological Disorders) 12/01/2010 - "Design and screening of ASIC inhibitors based on aromatic diamidines for combating neurological disorders."

Related Drugs and Biologics

1.	Acid Sensing Ion Channels
2.	Neuroprotective Agents
3.	Nitric Oxide Synthase (NO Synthase)
4.	Glutamate Receptors (Glutamate Receptor)
5.	Anti-Anxiety Agents (Anxiolytics)
6.	Diminazene
7.	Analgesics (Analgesic Drugs)
8.	Amiloride (Midamor)
9.	Acids