Cystadenofibroma

Benign or borderline malignant neoplasm of the ovary and surrounding tissues. It is characterized by tumor(s) with cystic glands which are lined by cuboidal EPITHELIAL CELLS with clear cytoplasm, resembling ENDOMETRIUM cells. The glands are separated by fibroblastic STROMAL CELLS.

Also Known As:

Benign Clear Cell Adenofibroma; Benign Cystadenofibroma; Borderline Clear Cell Adenofibroma; Borderline Cystadenofibroma; Clear Cell Adenofibroma; Adenofibroma, Clear Cell; Adenofibromas, Clear Cell; Benign Cystadenofibromas; Borderline Cystadenofibromas; Clear Cell Adenofibromas; Cystadenofibroma, Benign; Cystadenofibroma, Borderline; Cystadenofibromas; Cystadenofibromas, Benign; Cystadenofibromas, Borderline

Networked: 32 relevant articles (0 outcomes, 0 trials/studies)

Disease Context: Research Results

Neoplasms: 1324753
- Neoplasms by Histologic Type: 2
  - Glandular and Epithelial Neoplasms: 439
    - Neoplasms, Cystic, Mucinous, and Serous: 1223
      - Cystadenofibroma: 32
    - Fibroepithelial Neoplasms: 8
      - Adenofibroma: 62
        Cystadenofibroma: 32
  - Connective and Soft Tissue Neoplasms: 1
    - Connective Tissue Neoplasms: 9
      - Fibrous Tissue Neoplasms
        Fibroepithelial Neoplasms: 8
        Adenofibroma: 62
        Cystadenofibroma: 32

Related Diseases

1.	Neoplasms (Cancer)
2.	Carcinoma (Carcinomatosis)
3.	Endometriosis
4.	Cystadenofibroma
5.	Fibroma (Fibromatosis)

Experts

1.	Takano, Masashi: 3 articles (06/2012 - 02/2008)
2.	Xing, Deyin: 2 articles (01/2022 - 01/2018)
3.	Matsubara, Osamu: 2 articles (04/2012 - 02/2008)
4.	Tamai, Seiichi: 2 articles (04/2012 - 02/2008)
5.	Tsuda, Hitoshi: 2 articles (04/2012 - 02/2008)
6.	Yamamoto, Sohei: 2 articles (04/2012 - 02/2008)
7.	Deavers, Michael T: 2 articles (01/2012 - 02/2004)
8.	Malpica, Anais: 2 articles (01/2012 - 02/2004)
9.	Silva, Elvio G: 2 articles (01/2012 - 02/2004)
10.	Andersen, John: 1 article (01/2022)

Drugs and Biologics

Drugs and Important Biological Agents (IBA) related to Cystadenofibroma:

1.	DNA (Deoxyribonucleic Acid)IBA 01/01/1990 - "Our data on rat liver nuclei peritoneal washings from patients with ovarian cystadenofibromas and ovarian cystadenocarcinomas suggested that analysis of cytological material using the Papanicolaou method is not reliable and that destaining the slides followed by Feulgen staining provides an optimal and reliable method of DNA quantification." 04/01/2012 - "A total of 42 clear-cell carcinoma cases with adjacent putative precursor lesions (endometriosis-associated carcinoma cases (n=28) and (clear-cell) adenofibroma-associated carcinoma cases (n=14)) were selected and subjected to immunohistochemical analysis for ARID1A protein expression and direct genomic DNA sequencing of exons 9 and 20 of the PIK3CA gene. "
2.	AntibodiesIBA 03/01/2013 - "The institution of immunotherapy and removal of an ovarian cystadenofibroma led to full resolution of her symptoms with disappearance of serum NMDAR antibodies. " 01/01/1989 - "To determine the nature and differences in the cytokeratin profiles of ovarian CET, eight benign Brenner tumors, four serous cystadenofibromas, 28 mucinous tumors, 27 serous tumors and six endometrioid, five clear cell and five undifferentiated carcinomas, as well as nine normal ovaries were immunostained with the above five antibodies. "
3.	Proto-Oncogene Proteins c-sis (Platelet Derived Growth Factor B)IBA 02/01/2008 - "Positivity for platelet-derived growth factor B-chain increased in accordance with increased atypia in clear-cell adenofibroma: 0% in non-atypical clear-cell adenofibromas, 30% in atypical clear-cell adenofibromas, and 60% in coexisting carcinomas. "
4.	Telomerase (Telomerase Reverse Transcriptase)IBA 02/01/2004 - "Epithelial telomerase reverse transcriptase mRNA expression was detected in 28 of 31 epithelial ovarian carcinomas, 1 of 1 malignant granulosa cell tumor, 7 of 9 serous borderline ovarian tumors, 11 of 11 mucinous borderline ovarian tumors, 4 of 5 serous cystadenofibromas, 2 of 4 serous cystadenomas, 8 of 8 mucinous cystadenomas, and 0 of 6 normal ovaries except the corpus luteum. "
5.	Platelet-Derived Growth Factor Receptors (Platelet-Derived Growth Factor Receptor)IBA 02/01/2008 - "The frequencies of positivity for platelet-derived growth factor receptor-alpha and receptor-beta, and platelet-derived growth factor A-chain increased in accordance with higher cytologic atypia in the putative precursors: 71, 47, and 59% in the 17 non-atypical endometrioses, 84, 73, and 84% in the 19 atypical endometrioses, 0% each in the 10 non-atypical clear-cell adenofibromas, 100, 90, and 90% in the 10 atypical clear-cell adenofibromas, and 97, 97, and 100% in the 31 clear-cell adenocarcinomas, respectively. " 02/01/2008 - "Immunohistochemical expression of platelet-derived growth factor receptor-alpha and receptor-beta, platelet-derived growth factor A-chain and B-chain was examined in 31 cases of clear-cell adenocarcinoma and 56 coexisting putative precursor lesions: 17 non-atypical and 19 atypical endometrioses, and 10 non-atypical and 10 atypical clear-cell adenofibroma components. "
6.	N-Methylaspartate (NMDA)IBA 03/01/2013 - "Anti-N-methyl-d-aspartate encephalitis with ovarian cystadenofibroma."
7.	Testosterone (Sustanon)FDA Link 01/01/1990 - "One ovary, containing a simple cyst, released progesterone into the perfusate, and this release was further increased after the addition of hCG at a concentration of 10 IU/ml. A perfused cystadenofibroma released cAMP, progesterone, estradiol and testosterone into the perfusion medium with an augmented release of cAMP, estradiol and testosterone after the addition of hCG. "
8.	Messenger RNA (mRNA)IBA 02/01/2004 - "Epithelial telomerase reverse transcriptase mRNA expression was detected in 28 of 31 epithelial ovarian carcinomas, 1 of 1 malignant granulosa cell tumor, 7 of 9 serous borderline ovarian tumors, 11 of 11 mucinous borderline ovarian tumors, 4 of 5 serous cystadenofibromas, 2 of 4 serous cystadenomas, 8 of 8 mucinous cystadenomas, and 0 of 6 normal ovaries except the corpus luteum. "
9.	Proteins (Proteins, Gene)FDA Link 04/01/2012 - "A total of 42 clear-cell carcinoma cases with adjacent putative precursor lesions (endometriosis-associated carcinoma cases (n=28) and (clear-cell) adenofibroma-associated carcinoma cases (n=14)) were selected and subjected to immunohistochemical analysis for ARID1A protein expression and direct genomic DNA sequencing of exons 9 and 20 of the PIK3CA gene. "
10.	Progesterone FDA LinkGeneric 01/01/1990 - "One ovary, containing a simple cyst, released progesterone into the perfusate, and this release was further increased after the addition of hCG at a concentration of 10 IU/ml. A perfused cystadenofibroma released cAMP, progesterone, estradiol and testosterone into the perfusion medium with an augmented release of cAMP, estradiol and testosterone after the addition of hCG. "

Therapies and Procedures

1.	Salpingo-oophorectomy 11/04/2022 - "Ovarian remnant syndrome with paraintestinal ovarian serous cystadenofibroma arose 30 years after bilateral salpingo-oophorectomy: A case report." 05/02/2018 - "Bilateral salpingo-oophorectomy was performed, with pathology consistent with cystadenofibroma. " 06/17/2010 - "Cystadenofibromas confined to the fallopian tube can be treated curatively with unilateral salpingo-oophorectomy, without the need for any further treatment. " 01/01/2012 - "In this patient, WDPM was an incidental finding during a total abdominal hysterectomy and bilateral salpingo-oophorectomy for serous cystadenofibroma. " 01/01/2006 - "Her history revealed salpingo-oophorectomy for mucinous cystadenofibroma of the left ovary eight years before and cystectomy of the right ovary three years before. "
2.	Laparotomy 06/01/1995 - "Subsequent laparotomy revealed a benign tubal cystadenofibroma, but otherwise normal pelvic viscera. " 05/01/2004 - "The patient underwent an exploratory laparotomy, which revealed a large leiomyoma growing from a small rudimentary uterus, an indirect inguinal hernia, and bilateral benign serous cystadenofibroma. " 01/01/1989 - "Two of these patients had exploratory laparotomy at 6 and 9 months of observation; the first operation, for increasing size and septation, demonstrated a cystadenofibroma, and the second, for increasing pain, demonstrated a degenerating myoma. " 06/01/2001 - "Initial laparotomy revealed a 13-kg mass arising from the omentum, which was determined from frozen and paraffin sections to be serous cystadenofibroma. "
3.	Hysterectomy 01/01/2012 - "In this patient, WDPM was an incidental finding during a total abdominal hysterectomy and bilateral salpingo-oophorectomy for serous cystadenofibroma. " 01/01/1978 - "In a 72-year old patient a total hysterectomy and bilateral salpingo-oophorectomy were performed because of a proliferating serous cystadenofibroma of the right ovary. " 07/01/2000 - "We present a case of serous cystadenofibroma 2 cm in diameter in the epiploic appendix of the sigmoid as incidental finding in a 72-year-old patient who underwent hysterectomy and oophorectomy for endometrial carcinoma. " 11/04/2022 - "We report a rare case of ORS with paraintestinal ovarian serous cystadenofibroma that developed 30 years after total abdominal hysterectomy and BSO in a 73-year-old woman. "
4.	Cystectomy 01/01/2006 - "Her history revealed salpingo-oophorectomy for mucinous cystadenofibroma of the left ovary eight years before and cystectomy of the right ovary three years before. " 09/01/2004 - "Her history revealed adnexectomy for mucinous cystadenofibroma of the left ovary eight years ago, and cystectomy due to cystadenoma of the right ovary three years ago. "
5.	Hormone Replacement Therapy (Therapy, Hormone Replacement) 03/01/2013 - "Ovarian benign clear cell adenofibroma in a patient with premature ovarian failure after 8-year hormone replacement therapy."