NAV1.8 Voltage-Gated Sodium Channel

A voltage-gated sodium channel subtype that is expressed in nociceptors, including spinal and trigeminal sensory neurons. It plays a role in the transmission of pain signals induced by cold, heat, and mechanical stimuli.

Also Known As:

PN3 Sodium Channel; Peripheral Nerve Sodium Channel 3; SCN10A Sodium Channel alpha Subunit; Sodium Channel Protein Type 10 Subunit alpha; Sodium Channel Protein Type X; Type 10 Voltage-Gated Sodium Channel; Voltage-Gated Sodium Channel Type 10; NAV1.8 Voltage Gated Sodium Channel; Sodium Channel, PN3; Type 10 Voltage Gated Sodium Channel; Voltage Gated Sodium Channel Type 10; Voltage Gated Sodium Channel Type 10 Subunit alpha; Voltage-Gated Sodium Channel Type 10 Subunit alpha

Networked: 2 relevant articles (1 outcomes, 0 trials/studies)

Relationship Network

Bio-Agent Context: Research Results

Amino Acids, Peptides, and Proteins: 1
- Proteins: 484843

Experts

1.	Chancellor, M B: 1 article (06/2001)
2.	Erickson, K: 1 article (06/2001)
3.	Erickson, V: 1 article (06/2001)
4.	Fraser, M O: 1 article (06/2001)
5.	Kassotakis, L: 1 article (06/2001)
6.	Novakovic, S: 1 article (06/2001)
7.	Seki, S: 1 article (06/2001)
8.	Yoshimura, N: 1 article (06/2001)
9.	de Groat, W C: 1 article (06/2001)

Related Diseases

1.	Pain (Aches) 06/01/2001 - "Suppression of the tetrodotoxin-resistant sodium channel (PN3/SNS): a possible new treatment for bladder pain."
2.	Neuralgia (Stump Neuralgia) 03/15/1998 - "The novel sodium channel PN3/alpha-SNS, which was cloned from a rat dorsal root ganglion (DRG) cDNA library, is expressed predominantly in small sensory neurons and may contribute to the tetrodotoxin-resistant (TTXR) sodium current that is believed to be associated with central sensitization in chronic neuropathic pain states. "

Related Drugs and Biologics

1.	Tetrodotoxin (Tetradotoxin)
2.	Sodium