NAV1.5 Voltage-Gated Sodium Channel

A voltage-gated sodium channel subtype that mediates the sodium ion PERMEABILITY of CARDIOMYOCYTES. Defects in the SCN5A gene, which codes for the alpha subunit of this sodium channel, are associated with a variety of CARDIAC DISEASES that result from loss of sodium channel function.

Also Known As:

SCN5A Sodium Channel alpha Subunit; Sodium Channel Protein Type 5 Subunit alpha; Sodium Channel, Voltage-Gated, Type V, alpha Subunit; Type 5 Voltage-Gated Sodium Channel; Voltage-Gated Na+ Channel Na(v)1.5a; Voltage-Gated Sodium Channel Type 5; NAV1.5 Voltage Gated Sodium Channel; Type 5 Voltage Gated Sodium Channel; Voltage Gated Sodium Channel Type 5; Voltage Gated Sodium Channel Type 5 Subunit alpha; Voltage-Gated Sodium Channel Type 5 Subunit alpha

Networked: 2 relevant articles (0 outcomes, 1 trials/studies)

Bio-Agent Context: Research Results

Amino Acids, Peptides, and Proteins: 1
- Proteins: 484843

Experts

1.	Ding, P: 1 article (08/2019)
2.	Liu, Q: 1 article (08/2019)
3.	Wang, F-Z: 1 article (08/2019)
4.	Wang, X-J: 1 article (08/2019)
5.	Barros, Cassandra Mirtes Andrade Rego: 1 article (03/2013)
6.	Barros, Marcos Aurélio Lima: 1 article (03/2013)
7.	Burbano, Rommel Rodríguez: 1 article (03/2013)
8.	Canalle, Renata: 1 article (03/2013)
9.	Fernandes, Hygor Ferreira: 1 article (03/2013)
10.	Motta, Fábio José Nascimento: 1 article (03/2013)

Related Diseases

1.	Atrial Fibrillation 08/01/2019 - "The aim of this study was to analyze the correlations of the sodium channel, voltage-gated, type V, alpha subunit (SCN5A) gene polymorphisms with the onset of atrial fibrillation (AF), and its clinical significance. "
2.	Brugada Syndrome 03/18/2013 - "To date, mutations in the sodium channel, voltage-gated, type V, alpha subunit gene and glycerol-3-phosphate dehydrogenase 1-like gene are estimated to account for approximately 28% of Brugada syndrome probands. "

Related Drugs and Biologics

1.	Glycerolphosphate Dehydrogenase (Glycerol 3 Phosphate Dehydrogenase)