Claudin-3

A ubiquitously-expressed claudin subtype that acts as a general barrier-forming protein in TIGHT JUNCTIONS. Elevated expression of claudin-3 is found in a variety of tumor cell types, suggesting its role as a therapeutic target for specific ANTINEOPLASTIC AGENTS.

Also Known As:

Networked: 242 relevant articles (4 outcomes, 34 trials/studies)

Relationship Network

Bio-Agent Context: Research Results

Experts

1.	Santin, Alessandro D: 12 articles (01/2019 - 10/2004)
2.	Bellone, Stefania: 9 articles (01/2019 - 10/2004)
3.	Morin, Patrice J: 9 articles (01/2011 - 07/2003)
4.	Pecorelli, Sergio: 8 articles (12/2015 - 10/2004)
5.	Cocco, Emiliano: 6 articles (01/2019 - 07/2010)
6.	Sawada, Norimasa: 6 articles (10/2018 - 07/2007)
7.	Agarwal, Rachana: 5 articles (05/2008 - 07/2003)
8.	Martinez, Carlos Augusto Real: 4 articles (01/2022 - 04/2015)
9.	Pereira, José Aires: 4 articles (01/2022 - 04/2015)
10.	Murata, Masaki: 4 articles (10/2018 - 03/2012)

Related Diseases

1.	Hypoxia (Hypoxemia) 01/06/2023 - "(3) GOS, FOS, COS, ALA, RES, Arg, and EPA presented protective effects on epithelial damage in heat/hypoxia-exposed Caco-2/HT-29 cells by preventing the decrease in TEER, the increase in LY permeability, and/or decrease in TJ proteins zonula occludens-1 (ZO-1) and claudin-3 expression. " 01/01/2016 - "After 12 hours in an anoxia chamber, the cells were examined for Ac-tubulin and Ac-H3K9, cellular viability, cytotoxicity, claudin-3 and ZO-1 protein expression, and transwell permeability study. " 01/01/2022 - "In addition, YPF increased the expression of claudin 3, claudin 18, occludin, VE-cadherin, and β-catenin, attenuated the epithelial and endothelial hyperpermeability in vivo and/or in vitro, and the stress fiber formation in PMVECs after hypoxia. " 01/01/2021 - "Hyperthermia and/or hypoxia exposure disrupted the established monolayer by increasing paracellular permeability, decreasing ZO-1, claudin-3 and occludin protein/mRNA expression, while enhancing E-cadherin protein expression. "
2.	Colitis 12/01/2023 - "Loss of claudin-3 expression increases colitis risk by promoting Gut Dysbiosis." 01/01/2019 - "Additional induction of colitis evoked a downregulation of claudin-3 in both intestinal segments and an upregulation of claudin-4 in the jejunum. " 06/01/2023 - "It also increased claudin-3, ZO-1 and occludin expressions and decreased claudin-2 expression in the colon tissues of mice with colitis. " 08/27/2022 - "The results showed that oral gavage of MAS reduced the disease activity index (DAI), prevented colon shortening, attenuated colon tissue damage and inflammatory response, suppressed colonic oxidative stress and restored the protein expression of intestinal tight junction (TJ) protein (ZO-1, occludin and claudin-3) in mice with DSS-induced colitis. " 01/01/2014 - "In DSS colitis model, occludin and claudin-3 expression significantly decreased compared with the control mice (P<0.05); and octreotide treatment could only significantly upregulate claudin-3 expression compared with untreated DSS colitis mice (P<0.05). "
3.	Necrotizing Enterocolitis 12/01/2020 - "Nesfatin-1 ameliorates oxidative bowel injury in rats with necrotizing enterocolitis: The role of the microbiota composition and claudin-3 expression." 01/01/2022 - "Fecal HBD-2 and Claudin-3 may be potential biomarkers to predict the deterioration of necrotizing enterocolitis: A prospective study."
4.	Brain Edema (Cerebral Edema) 01/01/2018 - "Our results showed lithium alone posttreatment activated GSK-3β, therefore increasing active β-catenin and claudin-1 and claudin-3 expressions, which were accompanied with improved BBB integrity and ameliorated sensorimotor deficits and brain edema in ICH animals. "
5.	Neoplasms (Cancer) 04/06/2017 - "Recent studies have shown high claudin-3 levels in several solid tumors, but the regulation mechanism of claudin-3 expression remains poorly understood. " 08/14/2023 - "Several researches had shown that Claudin-3 (CLDN3) is overexpressed in various cancers and might be important in their growth and spread. " 10/19/2022 - "Here, the role of claudin-3 in tumor-induced lymphangiogenesis is investigated. " 10/19/2022 - "Claudin-3 inhibits tumor-induced lymphangiogenesis via regulating the PI3K signaling pathway in lymphatic endothelial cells." 10/01/2022 - "High claudin 3 expression was significantly correlated with tumor size >2 cm and menopausal status. "

Related Drugs and Biologics

1.	Proteins (Proteins, Gene)
2.	Claudin-1
3.	Occludin
4.	Catenins
5.	lipopolysaccharide-binding protein
6.	Junctional Adhesion Molecule A
7.	Lithium
8.	naringenin
9.	Claudin-4
10.	Tight Junction Proteins

Related Therapies and Procedures

1.	Therapeutics
2.	Drug Therapy (Chemotherapy)
3.	Precision Medicine
4.	Enema (Enemas)
5.	Investigational Therapies (Experimental Therapy)