Hydroxybenzoates

Benzoate derivatives substituted by one or more hydroxy groups in any position on the benzene ring.

Also Known As:

Hydroxybenzoic Acids; Acids, Hydroxybenzoic

Networked: 18 relevant articles (1 outcomes, 3 trials/studies)

Relationship Network

Bio-Agent Context: Research Results

Organic Chemicals: 133
- Hydrocarbons: 1713
  - Cyclic Hydrocarbons: 97
    - Aromatic Hydrocarbons: 291
      - Benzene Derivatives: 17
        Phenols: 677
        Hydroxybenzoates: 18
        Salicylates: 2339
        Gallic Acid: 845
        Parabens: 323
        protocatechuic acid: 223
        phenolic acid: 195
        nifuroxazide: 63
        2,3-dihydroxybenzoic acid: 61
        atranorin: 23
        WZB117: 22
        Depsides: 18
        ethyl protocatechuate: 12
        atraric acid: 11
        Pactamycin: 9
        lifibrol: 8
        methyl 3,4-dihydroxybenzoate: 6
        3,4-dihydroxybenzoate: 5
        2,4,6-trihydroxybenzoic acid: 4
        diffractaic acid: 4
        smenospondiol: 4
        alpha-resorcylic acid: 3
        evernic acid: 3
        ophiocordin: 3
        phytex: 3
        3-hydroxybenzoic acid: 2
        beta-resorcylic acid: 2
        chrome azurol S: 2
        HS 1500: 2
        jaboticabin: 2
        lobarstin: 2
        methyl gentisate: 2
        N-(4-hydroxyphenyl)-N-(1,1,1-trifluoro-2-propyl)-4-hydroxybenzamide: 2
        origanoside: 2
        PS 990: 2
        tetradecyl-2,3-dihydroxybenzoate: 2
        tosiben: 2
        1,3,5-tris((N,N',N''-2,3-dihydroxybenzoyl)aminomethyl)benzene: 1
        2,4,6-tribromo-3-hydroxybenzoic acid: 1
        3,5-dimethoxy-4-hydroxybenzoic acid: 1
        3-amino-4-hydroxybenzoic acid: 1
        4-(2,6-dihydroxybenzoyl)-3-formyl-5-hydroxybenzoic acid: 1
        4-(acetylamino)-5-guanidino-3-hydroxybenzoic acid: 1
        isopropyl 4-hydroxybenzoate: 1
        kelletinin A: 1
        piscidic acid: 1
        protocatechuic acid methyl ester: 1
        thielocin B3: 1
        tschimganidin: 1
        ((4-methoxybenzoyl)oxy)acetic acid
        11-O-protocatechuoyl-tri-O-methylnorbergenin
        2,3-dihydroxybenzohydroxamoyl adenylate
        2,4-dihydroxy-5-(2-benzimidazolylazo)benzoic acid
        2,4-dihydroxy-6-(1,2-dioxopropyl)benzoic acid
        2,4-dihydroxy-6-(1-hydroxy-2-oxopropyl)benzoic acid
        2,4-dihydroxy-6-(2-oxopropyl)benzoic acid
        2,6-dihydroxy-3,4-dimethylbenzoic acid methyl ester
        2,6-dihydroxy-3-(benzoimidazolyl-2'-azo)benzoic acid
        2-((2-(1H-imidazol-4-yl)ethyl)iminomethyl)-5-methylphenolate
        2-phenylethyl 2,6-dihydroxybenzoate
        3,5-diamino-4-hydroxybenzoic acid dihydrochloride
        3,5-diguanidino-4-(N-acetylamino)benzoic acid
        3,5-ditert-butyl-4-hydroxy-(2,4-ditert-butylphenyl)benzoate
        3-(2'-hydroxy-4',5'-diethoxybenzoyl)propionic acid
        3-amino-5-hydroxybenzoic acid
        3-chloro-4-hydroxybenzoate
        3-farnesyl-2-hydroxybenzoic acid
        3-fluoro-4-hydroxybenzoate
        3-hexaprenyl-4-hydroxybenzoic acid
        3-hydroxy-sulfonyloxybenzoic acid
        3-methoxy-5-methylphenyl 2,4-dihydroxy-6-methylbenzoate
        4,5-dihydroxy-3-methoxybenzoic acid
        4-(3-benzoyl-2-methyl-5-phenyl-1H-pyrrol-1-yl)-2-hydroxybenzoic Acid
        4-(4'-(2''-methoxy-4''-hydroxy-3'',6''-dimethylbenzoyloxy)-3',5',6'-trimethyl-2'-methoxybenzoyloxy)-2-methoxy-3,6-dimethylbenzoic acid
        4-amino-3-hydroxybenzoic acid
        4-hydroxy-5-formylbenzoic acid
        4-hydroxybenzoic acid hydrazide
        4-O-glucopyranosyl-3-hydroxybenzalcohol-7-O-3,4-dihydroxybenzoic acid
        4-O-methylcryptochlorophaeic acid
        5-((2-O-(beta-D-apiofuranosyl)-beta-D-glucopyranosyl)oxy)-2-hydroxybenzoic acid
        5-chloro-2-hydroxybenzoic acid
        6-tridecylresorcylic acid
        adunchalcone
        amidepsine A
        amidepsine B
        amidepsine C
        anziaic acid
        azepinostatin
        benzyl 2-hydroxy-3,6-dimethoxybenzoate
        benzyl 2-O-glucopyranosyl-2,6-dihydroxybenzoate
        benzyl-2,5-diacetoxybenzoate
        benzyl-2-beta-glucopyranosyloxybenzoate
        bis(2-(3-carboxyphenoxy)carbonylethyl)phosphinic acid
        bis(2-(4-carboxyphenoxy)carbonylethyl) phosphinic acid
        bis(methyl 4-(((4'-(aminocarbonyl)-1,1'-biphenyl-4-yl)carbonyl)amino)-3-hydroxybenzoate)
        butyl-2-(4-methoxyphenyl)-2-oxoacetate
        chloroatranorin
        cochliomycin A
        cochliomycin B
        cochliomycin C
        colletotric acid
        CRM646 A
        Benzoates: 426
        Hydroxybenzoates: 18
        Salicylates: 2339
        Gallic Acid: 845
        Parabens: 323
        protocatechuic acid: 223
        phenolic acid: 195
        nifuroxazide: 63
        2,3-dihydroxybenzoic acid: 61
        atranorin: 23
        WZB117: 22
        Depsides: 18
        ethyl protocatechuate: 12
        atraric acid: 11
        Pactamycin: 9
        lifibrol: 8
        methyl 3,4-dihydroxybenzoate: 6
        3,4-dihydroxybenzoate: 5
        2,4,6-trihydroxybenzoic acid: 4
        diffractaic acid: 4
        smenospondiol: 4
        alpha-resorcylic acid: 3
        evernic acid: 3
        ophiocordin: 3
        phytex: 3
        3-hydroxybenzoic acid: 2
        beta-resorcylic acid: 2
        chrome azurol S: 2
        HS 1500: 2
        jaboticabin: 2
        lobarstin: 2
        methyl gentisate: 2
        N-(4-hydroxyphenyl)-N-(1,1,1-trifluoro-2-propyl)-4-hydroxybenzamide: 2
        origanoside: 2
        PS 990: 2
        tetradecyl-2,3-dihydroxybenzoate: 2
        tosiben: 2
        1,3,5-tris((N,N',N''-2,3-dihydroxybenzoyl)aminomethyl)benzene: 1
        2,4,6-tribromo-3-hydroxybenzoic acid: 1
        3,5-dimethoxy-4-hydroxybenzoic acid: 1
        3-amino-4-hydroxybenzoic acid: 1
        4-(2,6-dihydroxybenzoyl)-3-formyl-5-hydroxybenzoic acid: 1
        4-(acetylamino)-5-guanidino-3-hydroxybenzoic acid: 1
        Hydroxybenzoate Ethers: 1
        isopropyl 4-hydroxybenzoate: 1
        kelletinin A: 1
        piscidic acid: 1
        protocatechuic acid methyl ester: 1
        thielocin B3: 1
        tschimganidin: 1
        ((4-methoxybenzoyl)oxy)acetic acid
        11-O-protocatechuoyl-tri-O-methylnorbergenin
        2,3-dihydroxybenzohydroxamoyl adenylate
        2,4-dihydroxy-5-(2-benzimidazolylazo)benzoic acid
        2,4-dihydroxy-6-(1,2-dioxopropyl)benzoic acid
        2,4-dihydroxy-6-(1-hydroxy-2-oxopropyl)benzoic acid
        2,4-dihydroxy-6-(2-oxopropyl)benzoic acid
        2,6-dihydroxy-3,4-dimethylbenzoic acid methyl ester
        2,6-dihydroxy-3-(benzoimidazolyl-2'-azo)benzoic acid
        2-((2-(1H-imidazol-4-yl)ethyl)iminomethyl)-5-methylphenolate
        2-phenylethyl 2,6-dihydroxybenzoate
        3,5-diamino-4-hydroxybenzoic acid dihydrochloride
        3,5-diguanidino-4-(N-acetylamino)benzoic acid
        3,5-ditert-butyl-4-hydroxy-(2,4-ditert-butylphenyl)benzoate
        3-(2'-hydroxy-4',5'-diethoxybenzoyl)propionic acid
        3-amino-5-hydroxybenzoic acid
        3-chloro-4-hydroxybenzoate
        3-farnesyl-2-hydroxybenzoic acid
        3-fluoro-4-hydroxybenzoate
        3-hexaprenyl-4-hydroxybenzoic acid
        3-hydroxy-sulfonyloxybenzoic acid
        3-methoxy-5-methylphenyl 2,4-dihydroxy-6-methylbenzoate
        4,5-dihydroxy-3-methoxybenzoic acid
        4-(3-benzoyl-2-methyl-5-phenyl-1H-pyrrol-1-yl)-2-hydroxybenzoic Acid
        4-(4'-(2''-methoxy-4''-hydroxy-3'',6''-dimethylbenzoyloxy)-3',5',6'-trimethyl-2'-methoxybenzoyloxy)-2-methoxy-3,6-dimethylbenzoic acid
        4-amino-3-hydroxybenzoic acid
        4-hydroxy-5-formylbenzoic acid
        4-hydroxybenzoic acid hydrazide
        4-O-glucopyranosyl-3-hydroxybenzalcohol-7-O-3,4-dihydroxybenzoic acid
        4-O-methylcryptochlorophaeic acid
        5-((2-O-(beta-D-apiofuranosyl)-beta-D-glucopyranosyl)oxy)-2-hydroxybenzoic acid
        5-chloro-2-hydroxybenzoic acid
        6-tridecylresorcylic acid
        adunchalcone
        amidepsine A
        amidepsine B
        amidepsine C
        anziaic acid
        azepinostatin
        benzyl 2-hydroxy-3,6-dimethoxybenzoate
        benzyl 2-O-glucopyranosyl-2,6-dihydroxybenzoate
        benzyl-2,5-diacetoxybenzoate
        benzyl-2-beta-glucopyranosyloxybenzoate
        bis(2-(3-carboxyphenoxy)carbonylethyl)phosphinic acid
        bis(2-(4-carboxyphenoxy)carbonylethyl) phosphinic acid
        bis(methyl 4-(((4'-(aminocarbonyl)-1,1'-biphenyl-4-yl)carbonyl)amino)-3-hydroxybenzoate)
        butyl-2-(4-methoxyphenyl)-2-oxoacetate
        chloroatranorin
        cochliomycin A
        cochliomycin B
        cochliomycin C
        colletotric acid
- Carboxylic Acids: 973
  - Hydroxy Acids: 94
    - Hydroxybenzoates: 18
  - Carbocyclic Acids
    - Benzoates: 426
      - Hydroxybenzoates: 18
        Salicylates: 2339
        Gallic Acid: 845
        Parabens: 323
        protocatechuic acid: 223
        phenolic acid: 195
        3-Hydroxyanthranilic Acid: 78
        nifuroxazide: 63
        2,3-dihydroxybenzoic acid: 61
        atranorin: 23
        WZB117: 22
        Depsides: 18
        ethyl protocatechuate: 12
        atraric acid: 11
        Pactamycin: 9
        lifibrol: 8
        methyl 3,4-dihydroxybenzoate: 6
        3,4-dihydroxybenzoate: 5
        2,4,6-trihydroxybenzoic acid: 4
        diffractaic acid: 4
        smenospondiol: 4
        alpha-resorcylic acid: 3
        evernic acid: 3
        ophiocordin: 3
        phytex: 3
        3-hydroxybenzoic acid: 2
        beta-resorcylic acid: 2
        chrome azurol S: 2
        HS 1500: 2
        jaboticabin: 2
        lobarstin: 2
        methyl gentisate: 2
        N-(4-hydroxyphenyl)-N-(1,1,1-trifluoro-2-propyl)-4-hydroxybenzamide: 2
        origanoside: 2
        PS 990: 2
        tetradecyl-2,3-dihydroxybenzoate: 2
        tosiben: 2
        1,3,5-tris((N,N',N''-2,3-dihydroxybenzoyl)aminomethyl)benzene: 1
        2,4,6-tribromo-3-hydroxybenzoic acid: 1
        3,5-dimethoxy-4-hydroxybenzoic acid: 1
        3-amino-4-hydroxybenzoic acid: 1
        4-(2,6-dihydroxybenzoyl)-3-formyl-5-hydroxybenzoic acid: 1
        4-(acetylamino)-5-guanidino-3-hydroxybenzoic acid: 1
        Hydroxybenzoate Ethers: 1
        isopropyl 4-hydroxybenzoate: 1
        kelletinin A: 1
        piscidic acid: 1
        protocatechuic acid methyl ester: 1
        thielocin B3: 1
        tschimganidin: 1
        ((4-methoxybenzoyl)oxy)acetic acid
        11-O-protocatechuoyl-tri-O-methylnorbergenin
        2,3-dihydroxybenzohydroxamoyl adenylate
        2,4-dihydroxy-5-(2-benzimidazolylazo)benzoic acid
        2,4-dihydroxy-6-(1,2-dioxopropyl)benzoic acid
        2,4-dihydroxy-6-(1-hydroxy-2-oxopropyl)benzoic acid
        2,4-dihydroxy-6-(2-oxopropyl)benzoic acid
        2,6-dihydroxy-3,4-dimethylbenzoic acid methyl ester
        2,6-dihydroxy-3-(benzoimidazolyl-2'-azo)benzoic acid
        2-((2-(1H-imidazol-4-yl)ethyl)iminomethyl)-5-methylphenolate
        2-phenylethyl 2,6-dihydroxybenzoate
        3,5-diamino-4-hydroxybenzoic acid dihydrochloride
        3,5-diguanidino-4-(N-acetylamino)benzoic acid
        3,5-ditert-butyl-4-hydroxy-(2,4-ditert-butylphenyl)benzoate
        3-(2'-hydroxy-4',5'-diethoxybenzoyl)propionic acid
        3-amino-5-hydroxybenzoic acid
        3-chloro-4-hydroxybenzoate
        3-farnesyl-2-hydroxybenzoic acid
        3-fluoro-4-hydroxybenzoate
        3-hexaprenyl-4-hydroxybenzoic acid
        3-hydroxy-sulfonyloxybenzoic acid
        3-methoxy-5-methylphenyl 2,4-dihydroxy-6-methylbenzoate
        4,5-dihydroxy-3-methoxybenzoic acid
        4-(3-benzoyl-2-methyl-5-phenyl-1H-pyrrol-1-yl)-2-hydroxybenzoic Acid
        4-(4'-(2''-methoxy-4''-hydroxy-3'',6''-dimethylbenzoyloxy)-3',5',6'-trimethyl-2'-methoxybenzoyloxy)-2-methoxy-3,6-dimethylbenzoic acid
        4-amino-3-hydroxybenzoic acid
        4-hydroxy-5-formylbenzoic acid
        4-hydroxybenzoic acid hydrazide
        4-O-glucopyranosyl-3-hydroxybenzalcohol-7-O-3,4-dihydroxybenzoic acid
        4-O-methylcryptochlorophaeic acid
        5-((2-O-(beta-D-apiofuranosyl)-beta-D-glucopyranosyl)oxy)-2-hydroxybenzoic acid
        5-chloro-2-hydroxybenzoic acid
        6-tridecylresorcylic acid
        adunchalcone
        amidepsine A
        amidepsine B
        amidepsine C
        anziaic acid
        azepinostatin
        benzyl 2-hydroxy-3,6-dimethoxybenzoate
        benzyl 2-O-glucopyranosyl-2,6-dihydroxybenzoate
        benzyl-2,5-diacetoxybenzoate
        benzyl-2-beta-glucopyranosyloxybenzoate
        bis(2-(3-carboxyphenoxy)carbonylethyl)phosphinic acid
        bis(2-(4-carboxyphenoxy)carbonylethyl) phosphinic acid
        bis(methyl 4-(((4'-(aminocarbonyl)-1,1'-biphenyl-4-yl)carbonyl)amino)-3-hydroxybenzoate)
        butyl-2-(4-methoxyphenyl)-2-oxoacetate
        chloroatranorin
        cochliomycin A
        cochliomycin B
        cochliomycin C

Experts

1.	Hercberg, Serge: 2 articles (10/2018 - 01/2013)
2.	Kesse-Guyot, Emmanuelle: 2 articles (10/2018 - 01/2013)
3.	Touvier, Mathilde: 2 articles (10/2018 - 01/2013)
4.	Araya-Maturana, Ramiro: 1 article (01/2022)
5.	Dai, Qi: 1 article (01/2022)
6.	Duarte, Yorley: 1 article (01/2022)
7.	Echeverría, Javier: 1 article (01/2022)
8.	Espinoza, Carolina: 1 article (01/2022)
9.	Fike, Landon T: 1 article (01/2022)
10.	Forero-Doria, Oscar: 1 article (01/2022)

Related Diseases

1.	Neoplasms (Cancer) 05/10/2020 - "Limited in vivo studies also provide evidence that some of these hydroxybenzoic acids (HBAs) inhibit tumor growth in animal models. " 05/10/2020 - "Do Aspirin and Flavonoids Prevent Cancer through a Common Mechanism Involving Hydroxybenzoic Acids?-The Metabolite Hypothesis." 08/05/2017 - "Hydroxycinnamic acids (HCAs) and hydroxybenzoic acids (HBAs) are antioxidant phytochemicals found in rice and effective for the prevention of human diseases including cancer. " 10/01/2013 - "This manuscript intends to structurally characterize the different phenolic compounds (flavonoids, hydroxycinnamates, hydroxybenzoates, coumarins, xanthones, chalcones, stilbenes, lignins and lignans) and their metabolic pathways as well as review the most important results regarding these compounds and their derivatives in cancer treatment and prevention both in tumor cell lines in vitro, in murine models in vivo and finally some results regarding human trials. "
2.	Breast Neoplasms (Breast Cancer) 01/01/2020 - "This study examined associations between subclasses of phenolic acids, including hydroxycinnamic and hydroxybenzoic acids intake, and risk of breast cancer. " 01/01/2013 - "In contrast, in women with higher alcohol use, intakes of hydroxybenzoic acids (2.28, 1.16-4.49, P (trend) = 0.04), flavonoids (2.46, 1.23-4.92, P (trend) = 0.01), anthocyanins (2.94, 1.32-6.53, P (trend) = 0.01), catechins (2.28, 1.19-4.36, P (trend) = 0.02), and proanthocyanidins (2.98, 1.40-6.33, P (trend) = 0.006) were associated with increased breast cancer risk. " 01/01/2013 - "In non-to-low alcohol drinkers, intakes of some classes of polyphenols were associated with decreased breast cancer risk: hydroxybenzoic acids (HR(Q4vsQ1) = 0.38, 95 % CI: 0.17-0.86, P (trend) = 0.005), flavonoids (0.35, 0.17-0.75, P (trend) = 0.02), flavonols (0.36, 0.18-0.74, P (trend) = 0.002), catechins (0.48, 0.22-1.05, P (trend) = 0.02), theaflavins (0.42, 0.19-0.93, P (trend) = 0.02), and proanthocyanidins (0.39, 0.18-0.84, P (trend) = 0.02). "
3.	Hypertension (High Blood Pressure) 01/01/2023 - "The highest (5th quintile) intake of flavonoids (mean: 368.46mg/day; OR: 0.83; 95%CI 0.70; 0.97), hydroxybenzoic acids (mean: 379.38mg/day; OR: 0.77; 95%CI: 0.66;0.91), and flavonols (mean: 44.13mg/day; OR: 0.79; 95%CI: 0.67; 0.93) was inversely associated with hypertension prevalence, compared to the lowest intake (1st quintile).Conclusions:Our findings demonstrate that the intake of flavonoids, hydroxybenzoic acids, and flavonols is associated with a lower prevalence of hypertension." 11/02/2018 - "This review explains the interaction of functional food bioactive compounds including polyphenols (phenolic acids [hydroxybenzoic acids and hydroxycinnamic acids], flavonoids [flavonols, flavones, flavanols, flavanones, isoflavones, proanthocyanidins], stilbenes, and lignans), terpenoids, carotenoids, alkaloids, omega-3 and polyunsaturated fatty acids, among others with critical enzymes (α- amylase, α- glucosidase, angiotensin-I converting enzyme [ACE], acetylcholinesterase [AChE], and arginase) linked to some degenerative diseases (type-2 diabetes, cardiovascular diseases [hypertension], neurodegenerative diseases [Alzheimer's disease] and erectile dysfunction). "
4.	Cardiovascular Diseases (Cardiovascular Disease) 10/29/2018 - "Intakes of dihydrochalcones, proanthocyaninidins, dihydroflavonols, hydroxybenzoic acids, and stilbenes were also associated with a decrease (13%, 19%, 24%, 24%, and 27%, respectively) in cardiovascular disease risk, when comparing tertile T3 to T1. " 11/02/2018 - "This review explains the interaction of functional food bioactive compounds including polyphenols (phenolic acids [hydroxybenzoic acids and hydroxycinnamic acids], flavonoids [flavonols, flavones, flavanols, flavanones, isoflavones, proanthocyanidins], stilbenes, and lignans), terpenoids, carotenoids, alkaloids, omega-3 and polyunsaturated fatty acids, among others with critical enzymes (α- amylase, α- glucosidase, angiotensin-I converting enzyme [ACE], acetylcholinesterase [AChE], and arginase) linked to some degenerative diseases (type-2 diabetes, cardiovascular diseases [hypertension], neurodegenerative diseases [Alzheimer's disease] and erectile dysfunction). "
5.	Tetraploidy 01/09/2019 - "Poulard di Ciano, presumably an autochthonous wheat of the Reggio Emilia province (northern Italy), showed a peculiar quali/quantitative phenolic profile (7097.03 μg/kg sum of total phenolic compounds and 1.97 sum of hydroxycinnamic acids to sum of hydroxybenzoic acids ratio) along with a tetraploid genome. "

Related Drugs and Biologics

1.	Coumaric Acids
2.	Phytochemicals
3.	Antioxidants
4.	Flavonoids
5.	Stilbenes
6.	Acids
7.	Lignans
8.	Chalcones
9.	Xanthones
10.	Lignin