Caspase Inhibitors

Endogenous and exogenous compounds and that either inhibit CASPASES or prevent their activation.

Also Known As:

Capase Activation Inhibitors; Caspase Activation Blockers; Caspase Activation Inhibitors; Caspase Blockers; Activation Blockers, Caspase; Activation Inhibitors, Capase; Activation Inhibitors, Caspase; Blockers, Caspase; Blockers, Caspase Activation; Inhibitors, Capase Activation; Inhibitors, Caspase; Inhibitors, Caspase Activation

Networked: 279 relevant articles (16 outcomes, 31 trials/studies)

Relationship Network

Bio-Agent Context: Research Results

Chemical Actions and Uses
- Pharmacologic Actions: 160
  - Molecular Mechanisms of Pharmacological Action: 24
    - Enzyme Inhibitors: 1659
      - Protease Inhibitors: 6291
        Cysteine Proteinase Inhibitors: 392
        Caspase Inhibitors: 279

Experts

1.	Park, Woo Hyun: 6 articles (09/2018 - 11/2008)
2.	Jaeschke, Hartmut: 3 articles (08/2020 - 05/2017)
3.	You, Bo Ra: 3 articles (03/2017 - 09/2009)
4.	Edelstein, Charles L: 3 articles (01/2014 - 03/2005)
5.	Zhang, John H: 3 articles (04/2004 - 05/2002)
6.	Nicholson, D W: 3 articles (08/2002 - 04/2000)
7.	Alpan, Oral: 2 articles (01/2022 - 01/2022)
8.	Bukhari, Zaheer: 2 articles (01/2022 - 01/2022)
9.	Gupta, Raavi: 2 articles (01/2022 - 01/2022)
10.	Ndhlovu, Lishomwa C: 2 articles (01/2022 - 01/2022)

Related Diseases

1.	Ischemia 01/01/2000 - "Because the severity of ischemia was mild in some studies, we tested the efficacy of these caspase inhibitors on moderately severe but transient forebrain and focal ischemic insults in the rat. " 10/25/2004 - "Here, we investigate the effects of different caspase inhibitors on the renal dysfunction and injury caused by ischemia-reperfusion of the rat kidney. " 10/25/2004 - "Differential effects of caspase inhibitors on the renal dysfunction and injury caused by ischemia-reperfusion of the rat kidney." 04/01/2001 - "In separate experiments, animals received various caspase inhibitors before the induction of ischemia. " 08/01/2000 - "In conclusion, these results give support to further research on the use of caspase inhibitors as add-on therapeutic agents for the treatment of ischemia."
2.	Brain Ischemia (Cerebral Ischemia) 02/01/2000 - "In summary, our study supports the concept that caspase inhibitors are beneficial in brain ischemia." 09/01/2003 - "Effects of Ginko Biloba and caspase inhibitors on brain ischemia in the Mongolian Gerbil." 06/15/2000 - "Broad spectrum caspase inhibitors have been found to reduce neurodegeneration caused by cerebral ischemia. " 01/01/2000 - "Caspase inhibitors reduce neuronal injury after focal but not global cerebral ischemia in rats." 01/01/2006 - "This article will discuss the molecular structures and activities of calpain and caspase inhibitors and their therapeutic efficacy in experimental brain ischemia. "
3.	Sepsis (Septicemia) 06/21/2016 - "On the other hand, broad caspase inhibitors, which have already been shown to improve survival in mouse models of sepsis, achieved both. " 01/01/2009 - "Our studies enhance the case for the use of caspase inhibitors in sepsis. " 01/01/2009 - "However, it has not been clearly demonstrated that caspase inhibitors improve survival in sepsis models when dosed post-insult. " 01/01/2009 - "Determining the prevalent mode of cell death would be valuable, as new therapeutic agents (eg, antiapoptotic drugs such as caspase inhibitors) may improve unsatisfactory outcomes in patients with severe sepsis. " 06/01/2001 - "The influence of caspase inhibitors on spontaneous and on CD95-triggered apoptosis was investigated in neutrophils from healthy volunteers and compared with neutrophils from patients with severe sepsis. "
4.	Stroke (Strokes) 06/01/1998 - "The so-called caspase inhibitors are promising therapeutic agents for the treatment of acute stroke and may be administered with other neuroprotective medications in humans in the near future." 04/01/2013 - "Caspase inhibitors: prospective therapies for stroke." 01/01/2006 - "However, further investigations are necessary for improvements in the structural design of calpain and caspase inhibitors for their persistent therapeutic efficacy in animal models of stroke and for clinical trials in the future." 06/01/2000 - "This information will influence the design of selective caspase inhibitors to further elucidate the role of caspases in biology and hopefully lead to the design of therapeutic agents to treat caspase-mediated diseases, such as rheumatoid arthritis, certain neurogenerative diseases and stroke." 05/17/2004 - "Oxamyl dipeptide caspase inhibitors developed for the treatment of stroke."
5.	Neurodegenerative Diseases (Neurodegenerative Disease) 11/01/2004 - "These findings suggest that systematically active broad-spectrum caspase inhibitors maybe useful in the treatment of neurodegenerative diseases such as PD and HD." 05/01/2002 - "It will be important to recognize these differences in the consideration of caspase inhibitors in the treatment of degenerative neurologic disease." 09/01/2022 - "The article reviews the findings about the activation of various upstream mechanisms associated with caspases in neurodegenerative disorders along with the recent progress in the generation of caspase inhibitors and the challenge faced in their development as therapeutic agents for neurological indications." 01/01/2000 - "These observations suggest that caspases actively contribute to the molecular pathogenesis of these diseases and support the development of caspase inhibitors as potential therapeutic approaches for chronic neurodegenerative disorders." 01/01/2014 - "Inhibition of apoptosis and promotion of normal cell survival by caspase inhibitors would be a tremendous benefit for reducing the side effects of cancer therapy and for control of neurodegenerative disorders such as Parkinson's, Alzheimer's, and Huntington's diseases. "

Related Drugs and Biologics

1.	benzyloxycarbonylvalyl-alanyl-aspartyl fluoromethyl ketone
2.	Antioxidants
3.	Calpain
4.	benzyloxycarbonyl-valyl-alanyl-aspartic acid
5.	Acetaminophen (Paracetamol)
6.	N-acetyl-tyrosyl-valyl-alanyl-aspartyl chloromethyl ketone
7.	N-Methylaspartate (NMDA)
8.	Ice
9.	Caspases
10.	Caspase 3 (Caspase-3)

Related Therapies and Procedures

1.	Therapeutics
2.	Injections
3.	Aftercare (After-Treatment)
4.	Chemoradiotherapy
5.	Intraventricular Infusions