Voltage-Gated Sodium Channel Blockers

A class of drugs that inhibit the activation of VOLTAGE-GATED SODIUM CHANNELS.

Also Known As:

Channel Blockers, Voltage-Gated Sodium; Voltage-Gated Sodium Channel Antagonists; Voltage-Gated Sodium Channel Inhibitors; Channel Blockers, Voltage Gated Sodium; Voltage Gated Sodium Channel Antagonists; Voltage Gated Sodium Channel Blockers; Voltage Gated Sodium Channel Inhibitors

Networked: 27 relevant articles (2 outcomes, 3 trials/studies)

Relationship Network

Bio-Agent Context: Research Results

Chemical Actions and Uses
- Pharmacologic Actions: 160
  - Therapeutic Uses: 47080
    - Cardiovascular Agents: 817
      - Sodium Channel Blockers: 584
        Voltage-Gated Sodium Channel Blockers: 27
  - Molecular Mechanisms of Pharmacological Action: 24
    - Membrane Transport Modulators
      - Sodium Channel Blockers: 584
        Voltage-Gated Sodium Channel Blockers: 27

Experts

1.	Alcántara Montero, A: 2 articles (03/2021 - 05/2018)
2.	Sánchez Carnerero, C I: 2 articles (03/2021 - 05/2018)
3.	Cummins, Theodore R: 2 articles (01/2011 - 11/2007)
4.	Felix, John P: 2 articles (09/2009 - 06/2005)
5.	Garcia, Maria L: 2 articles (09/2009 - 06/2005)
6.	Kaczorowski, Gregory J: 2 articles (09/2009 - 06/2005)
7.	Lyons, Kathryn A: 2 articles (09/2009 - 06/2005)
8.	Martin, William J: 2 articles (09/2009 - 06/2005)
9.	Parsons, William H: 2 articles (09/2009 - 06/2005)
10.	Priest, Birgit T: 2 articles (09/2009 - 06/2005)

Related Diseases

1.	Pain (Aches) 11/01/2022 - "Selective voltage-gated sodium channel blockers are of growing interest as treatment for pain. " 02/01/2008 - "In addition, recent reports show that CNS penetration by voltage-gated sodium channel blockers is not required for efficacy in pre-clinical pain models while others have reported that identification of subtype-selective small molecules is possible. " 07/01/2011 - "Global voltage-gated sodium channel blockers such as lidocaine have proven efficacy in treating pain but can be limited by adverse effects when administered systemically. " 06/04/2015 - "Voltage-gated sodium channel blockers are not traditionally recommended for osteoarthritis (OA) pain therapy, but given the large peripheral drive that follows OA development there is a rationale for their use. " 09/10/2020 - "We report the identification of a novel class of brain penetrant and voltage-gated sodium channel blockers, leading to the discovery of vixotrigine, a use-dependent sodium channel blocker with activity in in vivo models of pain. "
2.	Trigeminal Neuralgia (Tic Douloureux) 01/01/2023 - "Despite the exemplary efficacy of voltage-gated sodium channel blockers as a first-line treatment of trigeminal neuralgia, the pharmacological management of this excruciating facial pain condition remains a major issue, as these first-line drugs produce intolerable side effects in a significant portion of patients. "
3.	Facial Pain (Myofacial Pain) 01/01/2023 - "Despite the exemplary efficacy of voltage-gated sodium channel blockers as a first-line treatment of trigeminal neuralgia, the pharmacological management of this excruciating facial pain condition remains a major issue, as these first-line drugs produce intolerable side effects in a significant portion of patients. "
4.	Channelopathies 06/01/2015 - "This review highlights recent advances in the study of human channelopathies, animal toxins and channel structure that may facilitate the development of selective voltage-gated sodium channel blockers. " 06/01/2014 - "In the present study, the progress of the sodium channelopathies and the biological functions of voltage-gated sodium channel blockers are analyzed and summarized." 06/01/2014 - "[Progress in sodium channelopathies and biological functions of voltage-gated sodium channel blockers]."
5.	Chronic Pain 05/01/2018 - "Although evidence for voltage-gated sodium channel blockers in chronic pain management is limited, emerging research has identified this area as promising for additional clinical trials to better guide clinical practice." 05/01/2018 - "Role of voltage-gated sodium channel blockers in the treatment of chronic pain: Potential uses in clinical practice based on available evidence." 01/01/2009 - "Voltage-gated sodium channel blockers for the treatment of chronic pain." 06/02/2005 - "A new series of voltage-gated sodium channel blockers with potential for treatment of chronic pain is reported. " 03/01/2007 - "Chronic pain states and epilepsies are common therapeutic targets of voltage-gated sodium channel blockers. "

Related Drugs and Biologics

1.	Lidocaine (Xylocaine)
2.	Sodium
3.	Carbamazepine (Tegretol)
4.	Cytostatic Agents
5.	Sodium Channel Blockers
6.	Nerve Growth Factor (NGF)
7.	Phenytoin (Dilantin)
8.	Ligands
9.	Isoxazoles
10.	Cannabinoids

Related Therapies and Procedures

1.	Therapeutics