Voltage-Gated Sodium Channels

A family of membrane proteins that selectively conduct SODIUM ions due to changes in the TRANSMEMBRANE POTENTIAL DIFFERENCE. They typically have a multimeric structure with a core alpha subunit that defines the sodium channel subtype and several beta subunits that modulate sodium channel activity.

Also Known As:

Networked: 1295 relevant articles (19 outcomes, 93 trials/studies)

Relationship Network

Bio-Agent Context: Research Results

Experts

1.	Waxman, Stephen G: 52 articles (01/2021 - 11/2002)
2.	Dib-Hajj, Sulayman D: 29 articles (01/2020 - 08/2004)
3.	Wood, John N: 25 articles (10/2022 - 10/2004)
4.	Djamgoz, Mustafa B A: 24 articles (05/2022 - 08/2005)
5.	George, Alfred L: 21 articles (01/2020 - 01/2002)
6.	Escayg, Andrew: 20 articles (01/2022 - 01/2002)
7.	Cummins, Theodore R: 19 articles (01/2022 - 04/2004)
8.	Catterall, William A: 19 articles (01/2021 - 12/2007)
9.	Lampert, Angelika: 18 articles (12/2021 - 01/2007)
10.	Yamakawa, Kazuhiro: 17 articles (01/2020 - 03/2004)

Related Diseases

1.	Pain (Aches) 01/01/2021 - "In silico development of potential therapeutic for the pain treatment by inhibiting voltage-gated sodium channel 1.7." 10/01/2000 - "That blockers of voltage-gated sodium channels (VGSCs) are clinically effective for the treatment of pain associated with certain types of tissue injury suggests that these channels constitute such a target. " 10/18/2023 - "Machine learning study of the extended drug-target interaction network informed by pain related voltage-gated sodium channels." 07/11/2023 - "Machine Learning Study of the Extended Drug-target Interaction Network informed by Pain Related Voltage-Gated Sodium Channels." 01/01/2021 - "More than a decade of research utilizing rodent genetic models and pharmacological tools to study voltage-gated sodium channels in pain has begun to unravel the role of different subtypes. "
2.	Seizures (Absence Seizure) 07/01/2009 - "In the present study we have examined the correlation between the potency of structurally diverse compounds at voltage-gated sodium channels in vitro and their efficacy in a rodent model of acute generalised seizures induced by electroshock. " 01/01/2022 - "Voltage-gated sodium channels (VGSC or Nav), which are involved in the formation of excitable cell's action potential and can directly influence the excitability of neural networks, have been implicated in AD-related abnormal neuronal hyperactivity and higher incidence of spontaneous non-convulsive seizures. " 01/01/2022 - "In the last decade, various coding and noncoding sequence variations of voltage-gated sodium channels SCN2A have been identified in patients with seizures, implying their genetic base. " 01/01/2019 - "Voltage-gated sodium channels (NaV), which are crucial for regulating neuronal excitability, have been implicated in AD-related hippocampal hyperactivity and higher incidence of spontaneous non-convulsive seizures. " 01/01/2018 - "Over 80% of patients diagnosed with DS carry a de novo mutation within the voltage-gated sodium channel gene SCN1A and these patients suffer with drug resistant and life-threatening seizures. "
3.	Neuralgia (Stump Neuralgia) 10/01/2018 - "Additionally, genetic studies have suggested that patients with variants of voltage gated sodium channels may be more at risk of developing neuropathic pain in the presence of a disease trigger such as diabetes. " 01/01/2017 - "Clinical and experimental studies suggest that voltage-gated sodium channels (VGSCs) play a key role in the pathogenesis of neuropathic pain and that blocking agents against these channels can be potentially therapeutic. " 01/01/2015 - "The present study was conducted to determine changes in the expression of voltage-gated sodium channels (VGSCs) α-subunits after nerve injury and their relation with development of neuropathic pain. " 01/01/2006 - "A number of experimental studies in animals have suggested that voltage-gated sodium channels may play a crucial role in neuropathic pain. " 01/01/2023 - "Neuropathic pain can be related to the dysfunction of voltage-gated sodium channels, considering that these receptors regulate the induction of action potentials in nociceptive neurons. "
4.	Epilepsy (Aura) 01/01/2021 - "Voltage Gated Sodium Channel Genes in Epilepsy: Mutations, Functional Studies, and Treatment Dimensions." 05/01/2014 - "Case-control association study of polymorphisms in the voltage-gated sodium channel genes SCN1A, SCN2A, SCN3A, SCN1B, and SCN2B and epilepsy." 01/01/2007 - "Polymorphisms of drug targets may represent another genetic facet in epilepsy: a recent study demonstrated for the first time a polymorphism of a drug target (the alpha-subunit of a voltage-gated sodium channel) associated in clinical practice with differing response to two classic AEDs. " 10/01/2004 - "Studies with animal seizure models have indicated that changes in temporal and spatial expression of voltage-gated sodium channels may be important in the pathology of epilepsy. " 11/01/2002 - "Animal experiments, and particularly functional investigations on human chronically epileptic tissue as well as genetic studies in epilepsy patients and their families strongly suggest that some forms of epilepsy may share a pathogenetic mechanism: an alteration of voltage-gated sodium channels. "
5.	Channelopathies 02/01/2022 - "Recent data has revealed the role of voltage-gated sodium channels in the pathophysiology of the disease; hence, these disorders are referred to as channelopathies. " 01/01/2022 - "In this review, we will discuss the channelopathies associated with these fenestrations, which we collectively name "Fenestropathy," and how changes in the fenestrations associated with the opening of the intracellular gate could modulate the state-dependent ingress and egress of drugs binding in the central cavity of voltage gated sodium channels." 07/17/2020 - "Inter-Regulation of Kv4.3 and Voltage-Gated Sodium Channels Underlies Predisposition to Cardiac and Neuronal Channelopathies." 01/01/2018 - "We discovered a unique neurodevelopmental channelopathy resulting from pathogenic variants in SCN3A, a gene encoding the voltage-gated sodium channel NaV1.3. Pathogenic NaV1.3 channels showed altered biophysical properties including increased persistent current. " 01/01/2018 - "We focus specifically on the quest for modifying genes in inherited channelopathies, using the voltage-gated sodium channels as an example. "

Related Drugs and Biologics

1.	Anticonvulsants (Antiepileptic Drugs)
2.	Calcium Channels (Calcium Channel)
3.	eslicarbazepine acetate
4.	Sodium
5.	Lamotrigine (Lamictal)
6.	Carbamazepine (Tegretol)
7.	Cannabinoids
8.	Nerve Growth Factor (NGF)
9.	N-Methylaspartate (NMDA)
10.	Valproic Acid (Depakote)

Related Therapies and Procedures

1.	Therapeutics
2.	Drug Therapy (Chemotherapy)
3.	Adjuvant Chemotherapy
4.	Analgesia
5.	Axotomy