Hypoglossal Nerve Injuries

Traumatic injuries to the HYPOGLOSSAL NERVE.

Also Known As:

Cranial Nerve XII Injury; Hypoglossal Nerve Avulsion; Hypoglossal Nerve Contusion; Hypoglossal Nerve Transection; Hypoglossal Nerve Trauma; Hypoglossal Neuropathy, Traumatic; Injury, Cranial Nerve XII; Injury, Twelfth Cranial Nerve; Traumatic Twelfth-Nerve Palsy; Twelfth Cranial Nerve Injuries; Twelfth Cranial Nerve Injury; Twelfth-Nerve Palsy, Traumatic; Twelfth-Nerve Trauma; Avulsion, Hypoglossal Nerve; Avulsions, Hypoglossal Nerve; Contusion, Hypoglossal Nerve; Contusions, Hypoglossal Nerve; Hypoglossal Nerve Avulsions; Hypoglossal Nerve Contusions; Hypoglossal Nerve Injury; Hypoglossal Nerve Transections; Hypoglossal Nerve Traumas; Hypoglossal Neuropathies, Traumatic; Injuries, Hypoglossal Nerve; Injury, Hypoglossal Nerve; Nerve Avulsion, Hypoglossal; Nerve Avulsions, Hypoglossal; Nerve Contusion, Hypoglossal; Nerve Contusions, Hypoglossal; Nerve Injuries, Hypoglossal; Nerve Injury, Hypoglossal; Nerve Transection, Hypoglossal; Nerve Transections, Hypoglossal; Nerve Trauma, Hypoglossal; Nerve Traumas, Hypoglossal; Neuropathies, Traumatic Hypoglossal; Neuropathy, Traumatic Hypoglossal; Palsies, Traumatic Twelfth-Nerve; Palsy, Traumatic Twelfth-Nerve; Transection, Hypoglossal Nerve; Transections, Hypoglossal Nerve; Trauma, Hypoglossal Nerve; Trauma, Twelfth-Nerve; Traumas, Hypoglossal Nerve; Traumas, Twelfth-Nerve; Traumatic Hypoglossal Neuropathies; Traumatic Hypoglossal Neuropathy; Traumatic Twelfth Nerve Palsy; Traumatic Twelfth-Nerve Palsies; Twelfth Nerve Palsy, Traumatic; Twelfth Nerve Trauma; Twelfth-Nerve Palsies, Traumatic; Twelfth-Nerve Traumas

Networked: 54 relevant articles (0 outcomes, 5 trials/studies)

Disease Context: Research Results

Related Diseases

1.	Peripheral Nerve Injuries
2.	Lingual Nerve Injuries
3.	Cranial Nerve Injuries
4.	Tooth Injuries
5.	Wounds and Injuries (Trauma)

Experts

1.	Kiyama, Hiroshi: 6 articles (01/2010 - 06/2002)
2.	Kiyama, H: 4 articles (04/2001 - 01/2000)
3.	Namikawa, Kazuhiko: 3 articles (05/2006 - 06/2002)
4.	Tu, Ling: 2 articles (12/2015 - 10/2010)
5.	Konishi, Hiroyuki: 2 articles (01/2010 - 05/2006)
6.	Kiryu-Seo, Sumiko: 2 articles (05/2007 - 02/2007)
7.	Gigliotti, Michael J: 1 article (06/2021)
8.	Henry, Cathy: 1 article (06/2021)
9.	McLaughlin, Caroline: 1 article (06/2021)
10.	Patel, Neel: 1 article (06/2021)

Drugs and Biologics

Drugs and Important Biological Agents (IBA) related to Hypoglossal Nerve Injuries:

1.	Nerve Growth Factor (NGF)IBA 12/01/2015 - "Several studies have demonstrated that nerve growth factor may play a role in the repair process after peripheral nerve injury, but there has been little research focusing on the hypoglossal nerve injury and repair. " 10/01/2010 - "To explore the activation of phospho-p38 mitogen activated protein kinases (p-p38MAPK) and to evaluate the possible role of nerve growth factor (NGF) on neuronal protection and regeneration of injured nerve in a model of hypoglossal nerve injury in rats. "
2.	Immunoglobulin G (IgG)IBA 01/01/1995 - "In a previous study, we found immunoreactivity for complement factors C3, C3d, and C4d, as well as endogenous IgG in the hypoglossal nucleus following hypoglossal nerve transection, suggesting that activation of the complement cascade had taken place in the vicinity of the axotomized motorneurons. " 09/01/1992 - "Following hypoglossal nerve transection in adult rats, immunoreactivity for complement factor C3 and one of its degradation products C3d as well as C4d and immunoglobulin G (IgG) was observed in the ipsilateral hypoglossal nucleus. "
3.	Complement System Proteins (Complement)IBA 01/01/1995 - "In a previous study, we found immunoreactivity for complement factors C3, C3d, and C4d, as well as endogenous IgG in the hypoglossal nucleus following hypoglossal nerve transection, suggesting that activation of the complement cascade had taken place in the vicinity of the axotomized motorneurons. " 09/01/1992 - "Following hypoglossal nerve transection in adult rats, immunoreactivity for complement factor C3 and one of its degradation products C3d as well as C4d and immunoglobulin G (IgG) was observed in the ipsilateral hypoglossal nucleus. "
4.	ChemokinesIBA 01/01/2004 - "In this study, we examined the role of some chemokines and their receptors in the trafficking of rat MSCs (rMSCs) in a rat model of left hypoglossal nerve injury. " 01/01/2004 - "Interactions of chemokines and chemokine receptors mediate the migration of mesenchymal stem cells to the impaired site in the brain after hypoglossal nerve injury."
5.	Bromodeoxyuridine (BrdU)IBA 12/01/1994 - "A bromodeoxyuridine labelling study of proliferating cells in the brainstem following hypoglossal nerve transection." 12/01/1994 - "The proliferative activity in the hypoglossal nucleus following hypoglossal nerve injury has been studied with the 3H-thymidine analogue, bromodeoxyuridine (BrdUrd). "
6.	Pancreatitis-Associated ProteinsIBA 06/24/2005 - "In this study, we examined the expression of mRNAs for Regenerating gene (Reg)/pancreatitis-associated protein (PAP) family members following hypoglossal nerve injury in rats. "
7.	Messenger RNA (mRNA)IBA 11/20/1998 - "Following hypoglossal nerve injury, the expression of Tra2beta mRNA was elevated in injured motoneurons transiently. " 05/09/1995 - "The mRNA level was substantially induced by the hypoglossal nerve transection, suggesting that the up-regulation of RI alpha mRNA leading to the down-regulation of PKA activity may contribute to some intracellular signalling modulation or to muscle specific gene transcription after the denervation." 06/15/2002 - "The mRNA expression of the microtubule disassembly molecules (SCG10, stathmin, SCLIP and RB3) in response to nerve injury was examined using a rat hypoglossal nerve injury model. " 04/01/1998 - "An increase in 14-3-3 mRNA expression after hypoglossal nerve injury was demonstrated by RNA finger printing using the arbitrary primed polymerase chain reaction (RAP-PCR). " 03/01/1997 - "Calcitonin gene-related peptide and alpha-CGRP mRNA expression in cranial motoneurons after hypoglossal nerve injury during postnatal development."
8.	Proteins (Proteins, Gene)FDA Link 05/01/2006 - "We have identified annexin III (ANX III/ANX A3) as an induced protein after rat hypoglossal nerve injury. " 06/02/1997 - "Hypoglossal nerve transection resulted in a complete down-regulation of the FGF-2 protein 3 days after lesion. "
9.	MelatoninIBA 03/01/2008 - "Adult rats subjected to hypoglossal nerve transection were intraperitoneally injected with melatonin at ones for 3, 7, 14, 30 and 60 days successively. " 08/11/2000 - "Right-sided hypoglossal nerve transection was performed in adult rats following which the animals were given two different doses of melatonin administered intraperitoneally for 3, 7, 14, 21 and 30 successive days. "
10.	Leucine (L-Leucine)FDA Link 06/06/1986 - "Glucose and leucine uptake in the hypoglossal nucleus after hypoglossal nerve transection with and without prevented regeneration in the Sprague-Dawley rat." 10/31/1983 - "In order to partially test this hypothesis we attempted to induce moderate hypoglycemia by fasting rats for 3 days between the time of hypoglossal nerve transection and the time of [14C]2-deoxyglucose (2-DG) and [14C]leucine measurement. " 06/06/1986 - "We studied [14C]2-deoxyglucose and [14C]leucine uptake in the rat hypoglossal nucleus after hypoglossal nerve transection and when regeneration was prevented by placing a nylon ligature around the nerve proximal to the cut. "

Therapies and Procedures

1.	Denervation 12/01/2020 - "A magnetic resonance imaging revealed a denervation of the left half of the tongue from a hypoglossal nerve injury due to left extracranial internal carotid artery (ICA) dissection, without evidence of ischemic stroke. " 07/12/2012 - "Denervation atrophy of the tongue after hypoglossal-nerve injury." 05/09/1995 - "The mRNA level was substantially induced by the hypoglossal nerve transection, suggesting that the up-regulation of RI alpha mRNA leading to the down-regulation of PKA activity may contribute to some intracellular signalling modulation or to muscle specific gene transcription after the denervation."
2.	Axotomy 03/01/1993 - "Quantitative electron microscopy was used to examine synaptic numbers and total relative synaptic coverage on hypoglossal neuronal perikarya following hypoglossal nerve transection in the rat with or without pharmacological blockade of the axotomy-induced microglial cell proliferation. " 08/01/2002 - "To elucidate the c-Jun metabolism after axotomy, we investigated the expression of JNKs mRNA and of JNKs and c-Jun proteins following vagus and hypoglossal nerve transection. "
3.	Carotid Endarterectomy 02/01/1988 - "Bilateral hypoglossal nerve injury after bilateral carotid endarterectomy." 07/01/1988 - "In a prospective study of 52 carotid endarterectomies there were 13 temporary cranial nerve injuries in 12 patients (25%); 7 hypoglossal nerve injuries (13.5%), 3 were asymptomatic (5.8%), 2 had mild speech difficulty (3.8%) and 2 had severe difficulty with deglutition and articulation (3.8%). "
4.	Radiotherapy 07/26/2016 - "Previous exposure to radiation therapy is a potential cause of hypoglossal nerve injury. " 04/01/2000 - "Hypoglossal nerve injury occurring after head and neck radiotherapy is an indirect effect due to progressive soft tissue fibrosis and loss of vascularity. "
5.	Airway Management 03/01/2004 - "Hypoglossal nerve injury is a rare complication of anaesthesia airway management in adults. "