Olfactory Nerve Injuries

Traumatic injuries to the OLFACTORY NERVE. It may result in various olfactory dysfunction including a complete loss of smell.

Also Known As:

Cranial Nerve I Injury; First Cranial Nerve Injuries; First Cranial Nerve Injury; First-Nerve Palsy, Traumatic; First-Nerve Trauma; Injury, Cranial Nerve I; Injury, First Cranial Nerve; Olfactory Nerve Avulsion; Olfactory Nerve Contusion; Olfactory Nerve Transection; Olfactory Nerve Trauma; Olfactory Neuropathy, Traumatic; Traumatic First-Nerve Palsy; Avulsion, Olfactory Nerve; Avulsions, Olfactory Nerve; Contusion, Olfactory Nerve; Contusions, Olfactory Nerve; First Nerve Palsy, Traumatic; First Nerve Trauma; First-Nerve Palsies, Traumatic; First-Nerve Traumas; Injuries, Olfactory Nerve; Injury, Olfactory Nerve; Nerve Avulsion, Olfactory; Nerve Avulsions, Olfactory; Nerve Contusion, Olfactory; Nerve Contusions, Olfactory; Nerve Injuries, Olfactory; Nerve Injury, Olfactory; Nerve Transection, Olfactory; Nerve Transections, Olfactory; Nerve Trauma, Olfactory; Nerve Traumas, Olfactory; Neuropathies, Traumatic Olfactory; Neuropathy, Traumatic Olfactory; Olfactory Nerve Avulsions; Olfactory Nerve Contusions; Olfactory Nerve Transections; Olfactory Nerve Traumas; Olfactory Neuropathies, Traumatic; Palsies, Traumatic First-Nerve; Palsy, Traumatic First-Nerve; Transection, Olfactory Nerve; Transections, Olfactory Nerve; Trauma, First-Nerve; Trauma, Olfactory Nerve; Traumas, First-Nerve; Traumas, Olfactory Nerve; Traumatic First Nerve Palsy; Traumatic First-Nerve Palsies; Traumatic Olfactory Neuropathies; Traumatic Olfactory Neuropathy; Olfactory Nerve Injury

Networked: 22 relevant articles (0 outcomes, 3 trials/studies)

Disease Context: Research Results

Related Diseases

1.	Mental Disorders (Mental Disorder)
2.	Infarction (Infarctions)
3.	Craniocerebral Trauma (Head Injury)
4.	Brain Contusion

Experts

1.	Kobayashi, Masayoshi: 4 articles (01/2018 - 11/2006)
2.	Takeuchi, Kazuhiko: 3 articles (01/2018 - 07/2013)
3.	Tamari, Kengo: 3 articles (01/2018 - 07/2013)
4.	Amano, Ryohei: 3 articles (12/2009 - 01/2008)
5.	Furukawa, Mitsuru: 3 articles (12/2009 - 01/2008)
6.	Miwa, Takaki: 3 articles (12/2009 - 01/2008)
7.	Shiga, Hideaki: 3 articles (12/2009 - 01/2008)
8.	Washiyama, Kohshin: 3 articles (12/2009 - 01/2008)
9.	Miyamura, Tomotaka: 2 articles (02/2017 - 07/2013)
10.	Hirota, Kyoko: 2 articles (12/2009 - 09/2008)

Drugs and Biologics

Drugs and Important Biological Agents (IBA) related to Olfactory Nerve Injuries:

1.	NestinIBA 02/01/2014 - "This study explored the projection of nestin(+) neurons to the olfactory bulb and the time course of nestin(+) neurons in the medial septum-diagonal band of Broca in adult rats during injury recovery after olfactory nerve transection. "
2.	LectinsIBA 03/01/2003 - "Microglia in the olfactory bulb of rats during postnatal development and olfactory nerve injury with zinc sulfate: a lectin labeling and ultrastrucutural study."
3.	Zinc Sulfate FDA Link 03/01/2003 - "Microglia in the olfactory bulb of rats during postnatal development and olfactory nerve injury with zinc sulfate: a lectin labeling and ultrastrucutural study."
4.	Transforming Growth Factor alpha (TGF-alpha)IBA 01/01/2002 - "Consistent with a host of prior studies, olfactory nerve transection produced consistent and substantial deafferentation of olfactory bulb followed by a time-dependent anatomical recovery which was significantly enhanced by administration of TGF-alpha. " 01/01/2002 - "The effect of TGF-alpha on functional recovery following olfactory nerve transection was also assessed using an odor-guided fear conditioning task. " 01/01/2002 - "Administration of transforming growth factor-alpha enhances anatomical and behavioral recovery following olfactory nerve transection." 01/01/2002 - "The primary goal of the present experiments was to further assess the extent to which growth factor-related enhancements in the rate of anatomical recovery during ORN reconstitution and subsequent reinnervation of olfactory bulb are accompanied by enhancements in the rate of recovery of odor-guided behavior.A series of experiments in rats was conducted to initially characterize the time course of the anatomical and behavioral recovery normally observed following ORN reconstitution as a consequence of olfactory nerve transection, and to subsequently characterize the anatomical and behavioral effects of TGF-alpha administration on this normal rate of recovery. "
5.	Olfactory Marker ProteinIBA 02/01/2017 - "Olfactory nerve transection (NTx) was performed in olfactory marker protein (OMP-tau-lacZ) mice to establish injury models. " 01/01/2018 - "Olfactory nerve transection (NTx) was performed in olfactory marker protein (OMP)-tau-lacZ mice and subcutaneous injections of dexamethasone sodium phosphate for 5 consecutive days was started at 7, 14, 28, and 42 days after the NTx (7-, 14-, 28-, and 42-day time-points). "
6.	Odorant Receptors (Odorant Receptor)IBA 08/01/2009 - "To constitute the animal model of unilateral olfactory nerve transection and observe the expression level and distribution of odorant receptors. " 10/01/1992 - "This paper describes four investigations of the olfactory mucosa of the brown trout: 1) the ultrastructure of the olfactory mucosa as revealed by scanning (SEM), conventional transmission (TEM), and high voltage (HVEM) electron microscopy; 2) light and electron-microscopic investigations of retrograde transport of the tracer macromolecule horseradish peroxidase (HRP) when applied to the cut olfactory nerve; 3) SEM and TEM investigations of the effects of olfactory nerve transection on cell populations within the olfactory epithelium; and 4) ultrastructural investigations of reversible degeneration of olfactory receptors caused by elevated copper concentrations. "
7.	SteroidsIBA 02/01/2017 - "We previously reported that anti-inflammatory treatment with steroids improves recovery outcome in olfactory nerve injury models. " 07/01/2013 - "We previously reported that anti-inflammatory treatment with steroids improves recovery outcome in an olfactory nerve injury model. "
8.	Horseradish PeroxidaseIBA 09/01/2005 - "After olfactory nerve transection of mice, anterograde horseradish peroxidase (HRP) tracing was performed to confirm the completion of nerve transection. " 10/01/1992 - "This paper describes four investigations of the olfactory mucosa of the brown trout: 1) the ultrastructure of the olfactory mucosa as revealed by scanning (SEM), conventional transmission (TEM), and high voltage (HVEM) electron microscopy; 2) light and electron-microscopic investigations of retrograde transport of the tracer macromolecule horseradish peroxidase (HRP) when applied to the cut olfactory nerve; 3) SEM and TEM investigations of the effects of olfactory nerve transection on cell populations within the olfactory epithelium; and 4) ultrastructural investigations of reversible degeneration of olfactory receptors caused by elevated copper concentrations. "
9.	salicylhydroxamic acid (SHAM)IBA 12/01/2009 - "The rats were assessed 2, 14, 28, and 42 d after the olfactory nerve transection or sham operation for their ability to detect odours and for transport of 201Tl to the olfactory bulb area 8 h after nasal administration of 201Tl. " 11/01/1995 - "One group (n = 18) received bilateral olfactory nerve transection (BTX), while the second group (n = 4) received a sham surgical procedure. "
10.	Intercellular Signaling Peptides and Proteins (Growth Factors)IBA 01/01/2002 - "The primary goal of the present experiments was to further assess the extent to which growth factor-related enhancements in the rate of anatomical recovery during ORN reconstitution and subsequent reinnervation of olfactory bulb are accompanied by enhancements in the rate of recovery of odor-guided behavior.A series of experiments in rats was conducted to initially characterize the time course of the anatomical and behavioral recovery normally observed following ORN reconstitution as a consequence of olfactory nerve transection, and to subsequently characterize the anatomical and behavioral effects of TGF-alpha administration on this normal rate of recovery. "

Therapies and Procedures

1.	Length of Stay 11/01/2012 - "Compared with the control group, the GOS score was not significantly different in the unilateral-operation group, but the operation time, blood transfusion volume, length of hospital stay, incidence of mental disorder, and incidence of olfactory nerve injury were greatly reduced in the unilateral-operation group. " 01/01/2012 - "Compared with the control group, the Glasgow Outcome Scale score was not significantly different in the unilateral operation group, but the operation time, blood transfusion volume, the length of hospital stay, the incidences of mental disorder and olfactory nerve injury were greatly reduced in the unilateral operation group. "
2.	Blood Transfusion (Blood Transfusions) 11/01/2012 - "Compared with the control group, the GOS score was not significantly different in the unilateral-operation group, but the operation time, blood transfusion volume, length of hospital stay, incidence of mental disorder, and incidence of olfactory nerve injury were greatly reduced in the unilateral-operation group. " 01/01/2012 - "Compared with the control group, the Glasgow Outcome Scale score was not significantly different in the unilateral operation group, but the operation time, blood transfusion volume, the length of hospital stay, the incidences of mental disorder and olfactory nerve injury were greatly reduced in the unilateral operation group. "
3.	Operative Surgical Procedures 11/01/1995 - "One group (n = 18) received bilateral olfactory nerve transection (BTX), while the second group (n = 4) received a sham surgical procedure. "
4.	Subcutaneous Injections 01/01/2018 - "Olfactory nerve transection (NTx) was performed in olfactory marker protein (OMP)-tau-lacZ mice and subcutaneous injections of dexamethasone sodium phosphate for 5 consecutive days was started at 7, 14, 28, and 42 days after the NTx (7-, 14-, 28-, and 42-day time-points). "
5.	Intranasal Administration 12/01/2009 - "The rats were assessed 2, 14, 28, and 42 d after the olfactory nerve transection or sham operation for their ability to detect odours and for transport of 201Tl to the olfactory bulb area 8 h after nasal administration of 201Tl. "