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Potassium Ionophores

Chemical agents that increase the permeability of CELL MEMBRANES to POTASSIUM ions.

Also Known As:

Ionophore, Potassium; Ionophores, Potassium; Potassium Ionophore

Networked: 8 relevant articles (0 outcomes, 1 trials/studies)

Bio-Agent Context: Research Results

Chemical Actions and Uses
- Pharmacologic Actions: 160
  - Molecular Mechanisms of Pharmacological Action: 24
    - Membrane Transport Modulators
      - Ionophores: 906
        Potassium Ionophores: 8
- Specialty Uses of Chemicals
  - Ionophores: 906
    - Potassium Ionophores: 8

Experts

1.	Barboiu, Mihail: 1 article (07/2019)
2.	Brañas-Fresnillo, Virginia: 1 article (07/2019)
3.	Cózar-Castellano, Irene: 1 article (07/2019)
4.	García-Calvo, José: 1 article (07/2019)
5.	Legrand, Yves-Marie: 1 article (07/2019)
6.	Li, Yu-Hao: 1 article (07/2019)
7.	Perdomo, Germán: 1 article (07/2019)
8.	Torroba, Tomás: 1 article (07/2019)
9.	Klein, Christine: 1 article (01/2019)
10.	König, Peter: 1 article (01/2019)

Related Diseases

1.	Muscle Hypotonia (Hypotonia) 06/28/2022 - "In this study, we demonstrated that rat liver mitochondria, when exposed to a pulse of Sr2+ ions in the presence of valinomycin (a potassium ionophore) and cyclosporin A (a specific inhibitor of the permeability transition pore complex) under hypotonia, showed prolonged oscillations in K+ and Sr2+ fluxes, membrane potential, pH, matrix volume, rates of oxygen consumption and H2O2 formation. "
2.	Neuroblastoma 01/01/2019 - "Here, we investigated the role of the UPS and autophagy by applying the potassium ionophore Valinomycin in PINK1-deficient human fibroblasts and isogenic neuroblastoma cell lines generated by CRISPR/Cas9. " 11/24/2000 - "To determine whether the commonly used antimanic agents could prevent potassium efflux-induced cell damage and apoptosis and the underlying mechanisms, we treated SH-SY5Y human neuroblastoma cells with the potassium ionophore, valinomycin (2-100 microM) and observed cell shrinkage, mitochondria damage, a significant increase in of lactate dehydrogenase (LDH) activity and caspase-3 protein expression. "
3.	Neoplasms (Cancer) 12/15/2016 - "Salinomycin, a polyether antibiotic, acts as a highly selective potassium ionophore and has anticancer activity on various cancer cell lines. " 10/21/2013 - "The antibiotic salinomycin, a potassium ionophore, has recently been shown to be a potent compound to deplete chemoresistant cells like cancer stem like cells (CSC) in adenocarcinomas. "
4.	Insulinoma 07/11/2019 - "Here, we describe a series of synthetic substituted cereulide potassium ionophores that cause impressive selective activation of glucose-induced insulin secretion in a constitutive manner in rat insulinoma INS1E cells. "
5.	Dehydration (Water Stress) 07/01/1998 - "When the potassium ionophore valinomycin (18 mumol/l) was used to induce cell dehydration, the order of potency of the flavonoids in protecting against loss of filterability was apigenin > cirsimaritin = chrysoeriol-4'-O-glucoside > 3,5,7-trihydroxy 4'-methoxy flavone 7-rutinoside > luteolin = rutin > quercetin, whereas beta-naphtho flavone again enhanced the loss of filterability. "

Related Drugs and Biologics

1.	Valinomycin
2.	Cyclosporine (Ciclosporin)
3.	Ions
4.	Anti-Bacterial Agents (Antibiotics)
5.	salinomycin
6.	Caspase 3 (Caspase-3)
7.	Luteolin
8.	Apigenin
9.	Antimanic Agents
10.	Rutin (Rutoside)