Peroxiredoxin III

A THIOREDOXIN-dependent hydroperoxidase that is localized in the mitochondrial matrix. The enzyme plays a crucial role in protecting mitochondrial components from elevated levels of HYDROGEN PEROXIDE.

Also Known As:

Mitochondrial Thioredoxin-Dependent Antioxidant Protein SP-22; PRDX3 Peroxidase; Peroxiredoxin 3; Thioredoxin-Dependent Peroxide Reductase, Mitochondrial; Mitochondrial Thioredoxin Dependent Antioxidant Protein SP 22; Thioredoxin Dependent Peroxide Reductase, Mitochondrial

Networked: 83 relevant articles (2 outcomes, 8 trials/studies)

Relationship Network

Bio-Agent Context: Research Results

Experts

1.	Li, Lianqin: 6 articles (03/2019 - 07/2008)
2.	Han, Jin: 4 articles (01/2022 - 01/2011)
3.	Woo, Hyun Ae: 4 articles (01/2021 - 05/2009)
4.	Cunniff, Brian: 4 articles (01/2015 - 01/2012)
5.	Rhee, Sue Goo: 3 articles (01/2022 - 05/2009)
6.	Zhao, Yan: 3 articles (01/2022 - 03/2018)
7.	Song, In-Sung: 3 articles (11/2017 - 01/2011)
8.	Heintz, Nicholas H: 3 articles (01/2015 - 04/2013)
9.	Newick, Kheng: 3 articles (01/2015 - 01/2012)
10.	Ran, Qitao: 2 articles (05/2022 - 01/2022)

Related Diseases

1.	Osteoarthritis 05/01/2022 - "Overexpression of Peroxiredoxin 3 in Cartilage Reduces the Severity of Age-Related Osteoarthritis But Not Surgically Induced Osteoarthritis in Mice." 05/01/2022 - "The study objective was to determine whether overexpression of the mitochondrial antioxidant peroxidase, peroxiredoxin 3 (Prx3), reduces the severity of osteoarthritis (OA) in mice. "
2.	Inflammation (Inflammations) 10/01/2022 - "We describe here a positive feedback between mitochondrial H2O2 and p53 that downregulates sulfiredoxin and peroxiredoxin 3 leading to necroptosis in inflammation and obesity." 10/01/2023 - "Recent Advances: p53 together with mtROS drive necroptosis in acute inflammation through downregulation of sulfiredoxin and peroxiredoxin 3. Mitochondrial hydroorotate dehydrogenase is a key redox system in the regulation of ferroptosis. " 01/01/2020 - "AdipoRon treatment mitigated oxidative stress (-30% to 45% for 4-hydroxy-2-nonenal and peroxiredoxin 3, P < 0.0001) as well as inflammation in muscles of mdx mice (-35% to 65% for interleukin 1 beta, tumour necrosis factor alpha, and cluster of differentiation 68, a macrophage maker, P < 0.0001) while increasing the anti-inflammatory cytokine, interleukin 10 (~5-fold, P < 0.0001). " 02/01/2015 - "Phosphoserine dimers (2PS) reduced IL-8 secretion in H2 O2 -treated Caco-2 cells, and reduced H2 O2 -induced expression of genes involved in inflammation and generation of reactive oxygen species (ROS), including chemokine (C-C motif) ligand 5 (CCL5), lactoperoxidase (LPO), myeloperoxidase (MPO), neutrophil cytosolic factor 1/2 (NCF1/2), and nitric oxide synthase 2A (NOS2), and upregulated metallothionein 3 (MT3), peroxiredoxin 3 (PRDX3), and surfactant, pulmonary-associated protein D (SFTPD), which are involved in protection against oxidative stress and activation of the Nrf2 signaling pathway. "
3.	Wounds and Injuries (Trauma) 10/01/2015 - "The aim of the present study was to investigate the role of peroxiredoxin III (Prx III) in DOX-induced H9c2 cell injuries. " 01/01/2016 - "The results demonstrated that DOX not only markedly induced injuries, including cytotoxicity and apoptosis, it also increased the expression levels of peroxiredoxin III. Notably, pretreatment with sodium hydrosulfide significantly attenuated the DOX‑induced decrease in cell viability and increase in apoptosis, and also reversed the increased expression levels of peroxiredoxin III in H9c2 cardiomyocytes. " 01/01/2013 - "This study delineates the role of peroxiredoxin 3 (Prx3) in hair cell death induced by several etiologies of acquired hearing loss (noise trauma, aminoglycoside treatment, age). "
4.	Transient Ischemic Attack 05/01/2012 - "In the present study, we compared the immunoreactivities and levels of Trx/prx redox system, thioredoxin 2 (Trx2), thioredoxin reductase 2 (TrxR2) and peroxiredoxin 3 (Prx3), as well as neuronal death in the hippocampal CA1 region between the adult and young gerbil after 5 min of transient cerebral ischemia. " 05/01/2010 - "We observed chronological changes in the mitochondrial-specific antioxidant enzymes peroxiredoxin 3 (Prx3) and thioredoxin 2 (Trx2) and their neuroprotective effects in the hippocampal CA1 region after 5 min of transient cerebral ischemia in gerbils. "
5.	Cardiotoxicity 01/01/2016 - "Therefore, the aim of the present study was to investigate whether peroxiredoxin III is involved in the cardioprotection of H2S against DOX‑induced cardiotoxicity. " 01/01/2016 - "In addition, pretreatment of the H9c2 cells with N‑acetyl‑L‑cysteine, a scavenger of reactive oxygen species, prior to exposure to DOX markedly decreased the expression levels of peroxiredoxin III. In conclusion, the results of the present study suggested that exogenous H2S attenuates DOX‑induced cardiotoxicity by inhibiting the expression of peroxiredoxin III in H9c2 cells. " 01/01/2016 - "Hydrogen sulfide attenuates doxorubicin-induced cardiotoxicity by inhibiting the expression of peroxiredoxin III in H9c2 cells."

Related Drugs and Biologics

1.	Peroxidase (Myeloperoxidase)
2.	Proteins (Proteins, Gene)
3.	Antioxidants
4.	Reactive Oxygen Species (Oxygen Radicals)
5.	CC Chemokines
6.	Nitric Oxide Synthase (NO Synthase)
7.	Interleukin-8 (Interleukin 8)
8.	Pulmonary Surfactants (Pulmonary Surfactant)
9.	Phosphoserine
10.	Ligands

Related Therapies and Procedures

1.	Therapeutics
2.	Drug Therapy (Chemotherapy)