Programmed Cell Death 1 Ligand 2 Protein

A costimulatory B7 antigen that has specificity for the T-CELL receptor PROGRAMMED CELL DEATH 1 RECEPTOR. It is closely-related to CD274 antigen; however, its expression is restricted to DENDRITIC CELLS and activated MACROPHAGES.

Also Known As:

Networked: 5 relevant articles (0 outcomes, 1 trials/studies)

Bio-Agent Context: Research Results

Experts

1.	Alemany, Haizea: 1 article (01/2021)
2.	Bryan, Richard T: 1 article (01/2021)
3.	Cheng, K K: 1 article (01/2021)
4.	Cherf, Gerald Maxwell: 1 article (01/2021)
5.	Diep, Anh N: 1 article (01/2021)
6.	Dowell, Alexander C: 1 article (01/2021)
7.	Giaccia, Amato J: 1 article (01/2021)
8.	Goel, Anshita: 1 article (01/2021)
9.	Gordon, Naheema S: 1 article (01/2021)
10.	Huang, Wei: 1 article (01/2021)

Related Diseases

1.	Autoimmune Hepatitis 11/01/2020 - "Studies have shown that PD-1 and its ligand PD-L1 are abnormally expressed in autoimmune diseases, such as rheumatoid arthritis and autoimmune hepatitis, but its other ligand, PD-L2, has rarely been studied. "
2.	Autoimmune Diseases (Autoimmune Disease) 11/01/2020 - "Studies have shown that PD-1 and its ligand PD-L1 are abnormally expressed in autoimmune diseases, such as rheumatoid arthritis and autoimmune hepatitis, but its other ligand, PD-L2, has rarely been studied. "
3.	Rheumatoid Arthritis 11/01/2020 - "Studies have shown that PD-1 and its ligand PD-L1 are abnormally expressed in autoimmune diseases, such as rheumatoid arthritis and autoimmune hepatitis, but its other ligand, PD-L2, has rarely been studied. "
4.	Neoplasms (Cancer) 04/07/2009 - "It functions by binding and cross-linking the antigen B7-DC on dendritic cells, inducing tumor-specific cytotoxic T cells. " 01/01/2021 - "We found that the immune checkpoint ligand PD-L2 is robustly expressed in patient samples of ovarian cancers and other malignancies exhibiting suboptimal response to ICB but not in cancers that are ICB sensitive. " 11/01/2023 - "Repulsive Guidance Molecule b (RGMb), a regulator of Bone Morphogenetic Proteins (BMPs) signaling, interacts with the PD-ligand, PD-L2, at cancer cell membranes. "
5.	Ovarian Neoplasms (Ovarian Cancer) 01/01/2021 - "We found that the immune checkpoint ligand PD-L2 is robustly expressed in patient samples of ovarian cancers and other malignancies exhibiting suboptimal response to ICB but not in cancers that are ICB sensitive. "

Related Drugs and Biologics

1.	Ligands
2.	Bone Morphogenetic Proteins (Bone Morphogenetic Protein)