Programmed Cell Death 1 Receptor

An inhibitory T-lymphocyte receptor that has specificity for CD274 ANTIGEN and PROGRAMMED CELL DEATH 1 LIGAND 2 PROTEIN. Signaling by the receptor limits T cell proliferation and INTERFERON GAMMA synthesis. The receptor also may play an essential role in the regulatory pathway that induces PERIPHERAL TOLERANCE.

Also Known As:

Networked: 1999 relevant articles (186 outcomes, 201 trials/studies)

Relationship Network

Bio-Agent Context: Research Results

Experts

1.	Freeman, Gordon J: 11 articles (01/2021 - 08/2015)
2.	Wolchok, Jedd D: 10 articles (01/2021 - 07/2013)
3.	Postow, Michael A: 8 articles (01/2020 - 07/2013)
4.	Hodi, F Stephen: 8 articles (01/2019 - 03/2013)
5.	Johnson, Douglas B: 7 articles (12/2021 - 01/2018)
6.	Schadendorf, Dirk: 7 articles (10/2021 - 01/2015)
7.	Wang, Hao: 6 articles (05/2022 - 01/2020)
8.	Zhang, Wei: 6 articles (01/2022 - 01/2018)
9.	Ribas, Antoni: 6 articles (10/2021 - 01/2015)
10.	Li, Jing: 6 articles (03/2021 - 01/2017)

Related Diseases

1.	Neoplasms (Cancer) 01/01/2021 - "In vivo, BCMAxCD3 bsAb suppressed the growth of human MM tumors in murine xenogeneic models and showed potent combinatorial efficacy with programmed cell death protein 1 blockade. " 09/14/2020 - "NIR-PIT and CTLA4 blockade produced more complete remission in MOC1 tumors (44%) than NIR-PIT and programmed cell death protein 1 (PD-1) blockade (8%), which was reported in our previous paper. " 01/01/2022 - "The results presented herein showed that NK cells killed target tumor cells with similar efficiency regardless of PD-L1 expression, whereas PD-L1 expression on A20 tumor cells conferred significant tumor protection against rejection by CD8 T cells confirming the role of the co-inhibitory receptor PD-1 in the modulation of their cytotoxic activity. " 05/24/2023 - "PD-L1 (programmed death-ligand-1) expression was increased in CR cells; therefore, we assessed dual inhibition + PD1 (programmed cell death protein-1) blocking and report profound anti-tumor growth and improved immunity in CR tumors which in turn extended overall survival in mice. " 01/01/2017 - "Blockade of the programmed cell death protein 1 (PD1) pathway is clinically effective against human cancers. "
2.	Melanoma (Melanoma, Malignant) 01/01/2020 - "Blockade of the PD-1 receptor has revolutionized the treatment of metastatic melanoma, with significant increases in overall survival (OS) and a dramatic improvement in patient quality of life. " 10/01/2023 - "Combination regimens including ICIs directed against programmed cell death protein 1 (PD-1) with anti-cytotoxic T lymphocyte antigen-4 (CTLA-4) agents or, more recently, anti-lymphocyte-activation gene 3 (LAG-3) agents, have gained regulatory approvals for the treatment of metastatic cutaneous melanoma, with long-term follow-up data suggesting the possibility of cure for some patients with advanced disease. " 01/01/2022 - "In a melanoma model, adoptive transfer of CTLs lacking Plxna4 prolonged survival and improved therapeutic outcome, which was even stronger when combined with anti-programmed cell death protein 1 (PD-1) treatment. " 05/01/2023 - "MSKCC Cohort, mGC Cohort, and Melanoma Cohort were utilized to interrogate the predictive efficacy of ARID1A mutation to programmed cell death protein 1 (PD-1) blockade. " 01/01/2022 - "Inhibition of PERK suppressed macrophage immunosuppressive activity and could enhance the efficacy of immune checkpoint programmed cell death protein 1 inhibition in melanoma. "
3.	Non-Small-Cell Lung Carcinoma (Carcinoma, Non-Small Cell Lung) 02/01/2021 - "Thyroid function abnormality (TFA) is a common immune-related adverse event (irAEs), but the association between it and the efficacy of programmed cell death protein 1 (PD-1) inhibitor in advanced non-small cell lung cancer (NSCLC) is finitely understood. " 01/01/2021 - "Programmed cell death protein 1 (PD-1) inhibitors are the first-line treatment for advanced non-small-cell lung cancer (NSCLC) patients. " 01/01/2023 - "This study aimed to investigate whether the immunosenescence-related score is a critical prognostic predictor of anti-programmed cell death protein 1 (PD-1) axis inhibitors in elderly patients with advanced non-small cell lung cancer (NSCLC). " 01/01/2019 - "This study evaluated data derived from electronic health records of patients with metastatic non-small cell lung cancer treated with programmed cell death protein 1 (PD-1) inhibitors in the year following regulatory approval. " 06/01/2023 - "Targeting programmed cell death protein 1 (PD-1) for treatment of non-small-cell lung carcinoma (NSCLC); the recent advances."
4.	Lung Neoplasms (Lung Cancer) 04/01/2022 - "In the present study, after Lewis lung cancer mouse model formation, the experimental group mice were intraperitoneally injected with a programmed cell death protein 1 (PD-1) inhibitor. " 01/01/2023 - "A further analysis revealed an increase in exhausted cell states in lung cancer patients because of upregulation of programmed cell death protein 1 expression in GPR56+ T cells. " 01/01/2023 - "Programmed cell death protein-1/programmed cell death ligand-1 (PD-1/L1) inhibitor is a promising therapeutic option that can be used as either a first-line or second-line treatment for driver-negative advanced or metastatic squamous non-small cell lung cancers (sqNSCLC). " 05/17/2023 - "Thoracic [99mTc]NM-01 SPECT/CT was performed in lung cancer patients (n = 10) at baseline and 9-weeks following anti-programmed cell death protein 1 (PD-1) therapy. " 01/01/2016 - "We recently demonstrated that the genomic landscape of lung cancers substantially influences the response to programmed cell death 1 receptor (PD-1) blockade, providing new insights into the molecular determinants of the response to immunotherapy. "
5.	Stomach Neoplasms (Stomach Cancer) 10/01/2018 - "The present study was designed to explore the expression of programmed cell death protein 1 (PD-1) on peripheral blood T-cell subsets and its role in the clinicopathological features and prognosis of patients with metastatic gastric cancer. " 10/01/2018 - "High expression of programmed cell death protein 1 on peripheral blood T-cell subsets is associated with poor prognosis in metastatic gastric cancer." 01/01/2018 - "Programmed cell death protein 1 (PD-1) expression on CD4+ and CD8+ T-cells obtained from gastric cancer tissue was evaluated by multicolor flow cytometry. " 04/01/2016 - "Programmed cell death protein 1 expression is an independent prognostic factor in gastric cancer after curative resection." 01/01/2023 - "Recently, the use of immunochemotherapy in the treatment of advanced gastric cancer (GC) has been increasing and programmed cell death protein 1 (PD-1) inhibitors combined with chemotherapy has become the first-line treatment for advanced GC. "

Related Drugs and Biologics

1.	Immune Checkpoint Inhibitors
2.	Ligands
3.	B7-H1 Antigen
4.	Monoclonal Antibodies
5.	Proteins (Proteins, Gene)
6.	Nivolumab
7.	pembrolizumab
8.	Antibodies
9.	CTLA-4 Antigen
10.	Blocking Antibodies

Related Therapies and Procedures

1.	Therapeutics
2.	Immunotherapy
3.	Drug Therapy (Chemotherapy)
4.	Radiotherapy
5.	Cell- and Tissue-Based Therapy (Cell Therapy)