Inducible T-Cell Co-Stimulator Ligand

A B7 antigen that binds specifically to INDUCIBLE T-CELL CO-STIMULATOR PROTEIN on T-CELLS. It provides a costimulatory signal for T-cell proliferation and cytokine secretion.

Also Known As:

Antigens, CD275; B7-H2 Antigen; B7-H2 Ligand; B7-Like Protein Gl50; B7-Related Protein 1; B7-Related Protein-1; B7H2 Antigen; CD275 Antigen; Antigen, B7-H2; Antigen, B7H2; Antigen, CD275; B7 H2 Antigen; B7 H2 Ligand; B7 Like Protein Gl50; B7 Related Protein 1; CD275 Antigens; Inducible T Cell Co Stimulator Ligand; Ligand, B7-H2; Protein Gl50, B7-Like

Networked: 7 relevant articles (0 outcomes, 1 trials/studies)

Bio-Agent Context: Research Results

Experts

1.	Asai, Akio: 1 article (01/2020)
2.	Dianzani, Umberto: 1 article (01/2020)
3.	Hashiba, Tetsuo: 1 article (01/2020)
4.	Hayashi, Mikio: 1 article (01/2020)
5.	Hyoung Lee, Joo: 1 article (01/2020)
6.	Ito, Tomoki: 1 article (01/2020)
7.	Iwata, Ryoichi: 1 article (01/2020)
8.	Maruyama, Masato: 1 article (01/2020)
9.	Nakano, Ichiro: 1 article (01/2020)
10.	Nakano, Yosuke: 1 article (01/2020)

Related Diseases

1.	Inflammation (Inflammations) 07/01/2014 - "This study investigated single-nucleotide polymorphisms (SNP) of tyrosine-protein phosphatase non-receptor type 2 (PTPN2) and inducible T-cell co-stimulator-ligand gene (ICOSLG) in Chinese Han BD patients and healthy controls because SNPs of these two genes are associated with risk of developing other auto-inflammation diseases. "
2.	Neoplasms (Cancer) 09/01/2010 - "Furthermore, the increase of B7-H3 PBT was strongly associated with tumor invasion (P = 0.025) and advanced TNM stages (P = 0.019), whereas the decline of co-stimulatory ligand B7-H2 PBT was related to regional lymph node metastasis (P = 0.028) and aggressive tumor invasion (P = 0.031). " 01/01/2020 - "Inducible T-cell co-stimulator ligand (ICOSLG) is a member of the B7 family of immune regulatory ligands, expression of which in cancer is implicated in disease progression due to regulation of antitumor adaptive immunity. "
3.	Disease Progression 01/01/2020 - "Inducible T-cell co-stimulator ligand (ICOSLG) is a member of the B7 family of immune regulatory ligands, expression of which in cancer is implicated in disease progression due to regulation of antitumor adaptive immunity. "
4.	Acute Myeloid Leukemia (Acute Myelogenous Leukemia) 03/01/2013 - "43: 747-757] show that acute myeloid leukemia (AML) cells develop an adaptive immune phenotype switching mechanism: In response to attack by activated T cells, the leukemia cells quickly downregulate the T-cell costimulatory ligand B7-H2 and reciprocally upregulate the coinhibitory ligands B7-H1 and B7-DC in order to shut down T-cell activation via the PD-1 pathway. "
5.	Melanoma (Melanoma, Malignant) 01/01/2014 - "We have recently demonstrated that plasmacytoid dendritic cells (pDCs) accumulating within melanomas are prompted to express tumor necrosis factor (ligand) superfamily, member 4 (TNFSF4, best known as OX40L) and inducible T-cell co-stimulator ligand (ICOSL), hence becoming able to trigger TH2 and regulatory immune responses. "

Related Drugs and Biologics

1.	Tyrosine (L-Tyrosine)
2.	Phosphoprotein Phosphatases (Phosphatases, Protein)
3.	Ligands
4.	Monoclonal Antibodies
5.	OX40 Ligand
6.	Immunoglobulin G (IgG)
7.	AMG 557

Related Therapies and Procedures

1.	Intraperitoneal Injections