LIM-Homeodomain Proteins

A subclass of LIM domain proteins that include an additional centrally-located homeodomain region that binds AT-rich sites on DNA. Many LIM-homeodomain proteins play a role as transcriptional regulators that direct cell fate.

Also Known As:

Networked: 3 relevant articles (0 outcomes, 0 trials/studies)

Bio-Agent Context: Research Results

Experts

1.	Bhati, Mugdha: 1 article (12/2008)
2.	Craig, Vanessa J: 1 article (12/2008)
3.	Deane, Janet E: 1 article (12/2008)
4.	Jeffries, Cy: 1 article (12/2008)
5.	Lee, Christopher: 1 article (12/2008)
6.	Matthews, Jacqueline M: 1 article (12/2008)
7.	Nancarrow, Amy L: 1 article (12/2008)
8.	Ryan, Daniel P: 1 article (12/2008)
9.	Sunde, Margaret: 1 article (12/2008)
10.	Isobe, Yasushi: 1 article (07/2002)

Related Diseases

1.	Precursor Cell Lymphoblastic Leukemia-Lymphoma (Acute Lymphoblastic Leukemia) 07/25/2002 - "A novel chromosomal translocation t(1;14)(q25;q32) in pre-B acute lymphoblastic leukemia involves the LIM homeodomain protein gene, Lhx4."
2.	Renal Insufficiency (Renal Failure) 05/01/1998 - "Furthermore, we provide evidence for the first described mutations in a LIM-homeodomain protein which account for an inherited form of abnormal skeletal patterning and renal failure."
3.	Genetic Translocation (Chromosomal Translocation) 07/25/2002 - "A novel chromosomal translocation t(1;14)(q25;q32) in pre-B acute lymphoblastic leukemia involves the LIM homeodomain protein gene, Lhx4."
4.	Breast Neoplasms (Breast Cancer) 12/01/2008 - "LMO (LIM-only) and LIM-HD (LIM-homeodomain) proteins form a family of proteins that is required for myriad developmental processes and which can contribute to diseases such as T-cell leukaemia and breast cancer. "

Related Drugs and Biologics

1.	Proteins (Proteins, Gene)