Prostatein

A secreted prostate-specific protein which can bind non-polar steroids, cholesterol and a group of small, proline-rich peptides. The protein is specifically found in RATS and comprises three distinct secretoglobin-related subunits referred to as prostatic steroid-binding protein C1, C2 and C3.

Also Known As:

Networked: 16 relevant articles (0 outcomes, 0 trials/studies)

Bio-Agent Context: Research Results

Experts

1.	Bai, Xian-Guang: 1 article (06/2019)
2.	Hao, Li-Ya: 1 article (06/2019)
3.	Huang, Shao-Sen: 1 article (06/2019)
4.	Huang, Yao-Ping: 1 article (06/2019)
5.	Li, Ze-Yu: 1 article (06/2019)
6.	Wang, Zhong-Lin: 1 article (06/2019)
7.	Xia, Xi-Chao: 1 article (06/2019)
8.	Zhang, Jun-Feng: 1 article (06/2019)
9.	Zhao, Ming-Liang: 1 article (06/2019)
10.	Zheng, Xin-Hua: 1 article (06/2019)

Related Diseases

1.	Prostatitis 08/01/2007 - "Spontaneous and prostatic steroid binding protein peptide-induced autoimmune prostatitis in the nonobese diabetic mouse." 11/01/2002 - "Prostatein or steroid binding protein (PSBP) induces experimental autoimmune prostatitis (EAP) in NOD mice." 07/01/1997 - "Identification of rat prostatic steroid-binding protein as a target antigen of experimental autoimmune prostatitis: implications for prostate cancer therapy." 05/01/1998 - "Prostatein (or rat prostatic steroid binding protein) is a major autoantigen in experimental autoimmune prostatitis." 09/01/2013 - "In the comparative studies of the III A chronic prostatitis patients and healthy men, 5 proteins were detected as at least 2-fold differentially expressed, which were probably brevinin-2Eg, big endothelin-1, alpha-defensin 15, beta-defensin 134 and prostatic steroid-binding protein C2. "
2.	Neoplasms (Cancer) 01/01/2015 - "These data suggest that expression of Scgb2a1 in the adult prostate could be epigenetically reprogrammed by BPA exposure during prostate development, with potential implications for cancer risk and response to chemotherapeutics associated with prostatein binding." 03/19/2015 - "In particular, the levels of both factors were enriched in the basal-like tumors of the C3(1) TAg (SV40 large T antigen transgenic mice under control of the C3(1)/prostatein promoter) GEMM. " 07/01/1996 - "Alterations in apoptosis and associated mechanisms during mammary tumor progression were investigated in transgenic mice expressing the SV40 large T antigen (T(AG)) driven by the rat prostatic steroid-binding protein C3(1) 5'-flanking region. "
3.	Carcinoma (Carcinomatosis) 10/01/1997 - "Transgenic mice expressing the simian virus 40 large T-antigen (TAG) under the regulatory control of the rat prostatic steroid binding protein C3(1) gene develop mammary carcinomas (in females) and prostate carcinomas (in males). " 05/10/2007 - "As we targeted two de novo-occurring carcinomas of the mammary (MMTV-driven polyoma middle T antigen model, PyVmT) and prostate (TRAMP model) glands, we limited expression to these epithelial cells by driving DOX transactivator from the prostatein C3 promoter. " 08/07/1998 - "Human lipophilin C (77 residues; mass, 8854.1; pI, 4.94) was homologous to the rat prostatein C3 component and to human mammaglobin, a protein overexpressed in some mammary carcinomas. "
4.	Whooping Cough (Pertussis) 06/01/2013 - "The CAP model was made by injection of allogeneic prostatein purification liquid + Freund's complete adjuvant (1:1) and diphtheria, pertussis, tetanus (DPT) vaccine (0.5 mL). " 06/01/2019 - "A CP model was made in 30 adult male SD rats by intraperitoneal injection of 0.5 ml dyphtheria pertussis tetanus (DPT) vaccine and mixed solution of 1 ml prostatein extract and complete adjuvant in a 1∶1 ratio, and another 10 rats were injected with the same volume of normal saline as controls. "
5.	Tetanus 06/01/2013 - "The CAP model was made by injection of allogeneic prostatein purification liquid + Freund's complete adjuvant (1:1) and diphtheria, pertussis, tetanus (DPT) vaccine (0.5 mL). " 06/01/2019 - "A CP model was made in 30 adult male SD rats by intraperitoneal injection of 0.5 ml dyphtheria pertussis tetanus (DPT) vaccine and mixed solution of 1 ml prostatein extract and complete adjuvant in a 1∶1 ratio, and another 10 rats were injected with the same volume of normal saline as controls. "

Related Drugs and Biologics

1.	Tumor Viral Antigens (Large T Antigen)
2.	Prostatein
3.	Diphtheria-Tetanus-Pertussis Vaccine (DPT Vaccine)
4.	Proteins (Proteins, Gene)
5.	Mammaglobin B
6.	Mammaglobin A
7.	alpha-Defensins
8.	beta-Defensins
9.	Endothelin-1 (Endothelin 1)
10.	Trans-Activators (Trans-Acting Factor)

Related Therapies and Procedures

1.	Therapeutics
2.	Intraperitoneal Injections