Equol

A non-steroidal ESTROGEN generated when soybean products are metabolized by certain bacteria in the intestines.

Also Known As:

(+-)-Isomer of Equol; 3'-Hydroxy-Equol; 4'-O-Methyl Equol; 4'-methoxy-7-isoflavanol; 6'-Hydroxy-Equol; 3' Hydroxy Equol; 4' O Methyl Equol; 4' methoxy 7 isoflavanol; 6' Hydroxy Equol; Equol, 4'-O-Methyl

Networked: 297 relevant articles (28 outcomes, 83 trials/studies)

Relationship Network

Bio-Agent Context: Research Results

Heterocyclic Compounds: 198
- Fused-Ring Heterocyclic Compounds
  - 2-Ring Heterocyclic Compounds
    - Benzopyrans: 195
      - Chromones: 159
        Flavonoids: 9773
        Isoflavones: 2663
        Equol: 297
        4',7-dihydroxy-3,4-dihydroisoflavone: 1
        6-methoxyequol: 1
        5-hydroxy-equol

Experts

1.	Lampe, Johanna W: 13 articles (01/2021 - 07/2003)
2.	Akaza, Hideyuki: 9 articles (09/2016 - 08/2002)
3.	Mori, Mitsuru: 9 articles (09/2016 - 08/2002)
4.	Ueno, Tomomi: 8 articles (03/2018 - 05/2011)
5.	Adlercreutz, Herman: 8 articles (09/2012 - 04/2003)
6.	Uchiyama, Shigeto: 7 articles (03/2018 - 09/2011)
7.	Tsukamoto, Taiji: 7 articles (09/2016 - 08/2002)
8.	Atkinson, Charlotte: 7 articles (01/2016 - 07/2003)
9.	Wähälä, Kristiina: 7 articles (01/2016 - 04/2003)
10.	Ho, Suzanne C: 6 articles (01/2021 - 01/2013)

Related Diseases

1.	Prostatic Neoplasms (Prostate Cancer) 02/01/2011 - "Although some observational and intervention studies suggest that the ability to produce equol is associated with reduced risk of breast and prostate cancer, CVD, improved bone health and reduced incidence of hot flushes, others have reported null or adverse effects. " 01/01/2016 - "Overall, the data from the present study demonstrate that S-equol has significant anti-prostate cancer activities in vitro and in vivo, and indicate that its anticancer effects were likely associated with the activation of FOXO3a via an Akt-specific pathway and inhibitory effects on MDM2 expression. " 01/01/2016 - "Mechanistic studies showed that S-equol targeted the Akt/FOXO3a pathway, which is important for prostate cancer cell survival, cell cycle progression and apoptosis. " 11/01/2010 - "Some studies on high soy-consuming populations reported an inverse association between urinary and serum equol concentrations and breast and prostate cancer risk. " 07/01/2010 - "Several studies in Asian men report lower equol concentrations or a lower prevalence of equol-producers among men with prostate cancer compared with controls, whereas studies in European populations report no association. "
2.	Hot Flashes 07/01/2010 - "In the confirmation study, menopausal women who were equol nonproducers who consumed 10 mg/d of natural S-equol for 12 wk had significantly reduced severity and frequency of hot flashes as well as a significant reduction in the severity of neck or shoulder stiffness. " 03/01/2015 - "Clinical trials that evaluated the efficacy of an S-equol-containing product found that VMS were alleviated but these trials were limited in scope and primarily involved Japanese women for whom hot flashes are a minor complaint. " 02/01/2019 - "In conclusion, this study found that supplementing equol to equol nonproducers significantly lowered the incidence and/or severity of hot flashes in menopausal women." 02/01/2019 - "Equol Decreases Hot Flashes in Postmenopausal Women: A Systematic Review and Meta-Analysis of Randomized Clinical Trials." 03/01/2015 - "The only trial in the United States evaluating hot flashes found symptoms were significantly reduced by S-equol, but the study lacked a placebo group, although it did include a positive control. "
3.	Neoplasms (Cancer) 03/01/2004 - "Only one third to one half of individuals produce equol, and evidence exists to support potential cancer-protective effects of equol production. " 03/06/2015 - "This study therefore implicates c-Myc as a potential regulator of the cancer-promoting effects of equol via up-regulation of eIF4GI and selective initiation of translation on mRNAs that utilize non-canonical initiation, including certain oncogenes. " 07/01/2014 - "In the present study, we use the SMMC-7721 cancer cell line to investigate the mechanisms of (±)-equol-induced, R-(+)-equol-induced, and S-(-)-equol-induced apoptosis. " 07/01/2010 - "Mechanisms of action of equol described using in vitro studies suggest possible effects of this compound in relation to cancer risk. " 01/01/2022 - "Together, these results suggest that equol may have a dual effect on ER-positive cancer cells, acting with, antiproliferative activity through PAPD5 and exhibiting proliferative activity via ERα and the former could be associated with miR-320a."
4.	Metabolic Bone Diseases (Osteopenia) 09/01/2017 - ": Twice daily RCE intake over 1 y potently attenuated BMD loss caused by estrogen deficiency, improved bone turnover, promoted a favorable estrogen metabolite profile (2-OH:16α-OH), and stimulated equol production in postmenopausal women with osteopenia. " 09/01/2012 - "These results indicate that isoflavone alone did not inhibit postgastrectomy osteopenia, but the combination of isoflavone and fructooligosaccharides improved the inhibition of trabecular bone loss by increasing calcium absorption and equol production through fructooligosaccharides supplementation." 06/01/2010 - "Effects of isoflavones equol and genistein on bone quality in a rat osteopenia model."
5.	Breast Neoplasms (Breast Cancer) 10/01/2012 - "The potential protective effects of equol in breast cancer are still under debate. " 02/19/2021 - "This review is focused on how equol affects breast cancer, as evidenced by in vivo and in vitro studies. " 01/01/2021 - "This study aimed to determine the antitumor effects of equol and investigate the impact of adding equol to therapeutic agents for breast cancer using breast cancer cell lines. " 01/01/2019 - "Our study revealed the mechanism of S-equol against breast cancer, and miR-10a-5p may be a potential target for the treatment of breast cancer." 01/01/2019 - "Based on this, the purpose of this study was to investigate the anti-breast cancer mechanism of S-equol. "

Related Drugs and Biologics

1.	Isoflavones
2.	Estrogens (Estrogen)
3.	Biomarkers (Surrogate Marker)
4.	daidzein
5.	Estrogen Receptors
6.	Lipids
7.	C-Reactive Protein
8.	Phytoestrogens (Phytoestrogen)
9.	Tamoxifen
10.	LDL Cholesterol

Related Therapies and Procedures

1.	Therapeutics
2.	Injections
3.	Chemoprevention
4.	Secondary Prevention
5.	Hormone Replacement Therapy (Therapy, Hormone Replacement)