Fetuins

A family of calcium-binding alpha-globulins that are synthesized in the LIVER and play an essential role in maintaining the solubility of CALCIUM in the BLOOD. In addition the fetuins contain aminoterminal cystatin domains and are classified as type 3 cystatins.

Also Known As:

Networked: 145 relevant articles (4 outcomes, 13 trials/studies)

Relationship Network

Bio-Agent Context: Research Results

Experts

1.	Jahnen-Dechent, Willi: 5 articles (11/2005 - 01/2002)
2.	Leite-Browning, Maria L: 3 articles (01/2005 - 11/2002)
3.	Matrisian, Lynn M: 3 articles (01/2005 - 11/2002)
4.	Ochieng, Josiah: 3 articles (01/2005 - 11/2002)
5.	Sreevatsan, Srinand: 2 articles (01/2018 - 01/2009)
6.	Seidel, G E: 2 articles (06/2008 - 06/2002)
7.	Grunberger, George: 2 articles (11/2006 - 08/2002)
8.	Mathews, Suresh T: 2 articles (11/2006 - 08/2002)
9.	Ketteler, Markus: 2 articles (11/2005 - 01/2002)
10.	Westenfeld, Ralf: 2 articles (11/2005 - 01/2002)

Related Diseases

1.	Neoplasms (Cancer) 11/01/2002 - "Our data therefore are consistent with the model that fetuin binds to the cell surface of tumor cells and acts to localize and anchor other molecules important during tumor progression to the plasma membrane." 11/01/2002 - "The association of iodinated fetuin to the cell surface of intact cultured cells derived from a murine tumor with squamous (B9) and spindle (A5) morphologies was determined by binding experiments and Scatchard analysis. " 11/01/2002 - "We hypothesize that fetuin plays a role in tumor progression of cell types which by themselves do not have the ability to express fetuin. " 08/01/2001 - "This last observation contradicts earlier suggestions that fetuin is specifically reduced in cancer patients. " 05/26/2001 - "Interestingly, while the fetuin isolated from fetal serum selectively induces apoptosis in cancer without affecting normal cells, the fetuin isolated from mature serum is completely inactive. "
2.	Insulin Resistance 11/17/2006 - "Taken together, this study suggests that the absence of fetuin may contribute to the improvement of insulin sensitivity associated with aging." 07/01/2010 - "Recently, the biological functions of fetuin, such as calcification and insulin resistance, have been clarified. " 11/17/2006 - "Earlier we have shown that fetuin-null (KO) mice demonstrate improved insulin sensitivity and resistance to diet-induced obesity. " 08/01/2013 - "It has been observed that fetuin-null mice are resistant to diet-induced obesity and they exhibit increased insulin sensitivity. " 11/17/2006 - "Fetuin-null mice are protected against obesity and insulin resistance associated with aging."
3.	Human Influenza (Influenza) 06/10/1995 - "Human influenza virus A/PR/8/34 (H1N1) was labeled with the alkylamine derivatives, and a variety of parameters for labeling were tested in a fetuin-immobilized microplate solid-phase assay. " 01/01/1987 - "Neuraminidases of 18 strains of avian influenza A virus were examined by both colorimetric and fluorometric assays using fetuin and 4-methylumbelliferyl-N-Ac-alpha-D-neuraminide as substrates, respectively, to compare them with those of human influenza A and B viruses. " 11/10/2006 - "This result could be improved to detect the neuraminidase subtype of almost all human influenza A viruses from a large panel of viruses isolated from 2000 to 2005, if the fetuin pre-coating was removed and the viruses were coated directly onto wells. " 02/01/2007 - "Glycopolypeptides carrying Neu5Acalpha2,6LacNAc inhibited hemagglutination mediated by influenza A and B viruses, and their relative binding affinities for hemagglutinin were 10(2)- to 10(4)-fold higher than that of the naturally occurring fetuin control. " 05/23/1977 - "Surface antigens of Myxovirus influenzas A/r8/34 and A/Hong Kong/1/68 were isolated on Fetuin covalently attached to Sepharose. "
4.	Obesity 01/01/2014 - "Our recent proteomic study has shown that fetuins may play sex-dependent roles in obesity and diabetes. " 11/17/2006 - "Earlier we have shown that fetuin-null (KO) mice demonstrate improved insulin sensitivity and resistance to diet-induced obesity. " 08/01/2013 - "It has been observed that fetuin-null mice are resistant to diet-induced obesity and they exhibit increased insulin sensitivity. " 11/17/2006 - "Fetuin-null mice are protected against obesity and insulin resistance associated with aging." 01/01/1998 - "Differential expression of insulin receptor tyrosine kinase inhibitor (fetuin) gene in a model of diet-induced obesity."
5.	Fibrosis (Cirrhosis) 10/31/2007 - "To investigate the potential role of fetuin and pentoxifylline in fibrosis we used MCM samples obtained from patients with biopsy proven hepatic fibrosis related to Hepatitis C (HCV). " 10/31/2007 - "Our results suggest that fetuin may be beneficial in hepatic fibrosis and suggest that combination of fetuin and pentoxifylline may target the two key events in hepatic fibrosis by modifying the effects of TGFbeta and PDGF, the two major growth factors in fibrosis." 08/14/1996 - "Fetuin expression was reduced by 45% in liver cirrhosis induced by bile duct ligation, but not in cirrhosis induced by carbon tetrachloride/Phenobarbital, as compared to controls. "

Related Drugs and Biologics

1.	Glucose (Dextrose)
2.	Insulin (Novolin)
3.	Bovine Serum Albumin
4.	Neuraminidase (Sialidase)
5.	Intercellular Signaling Peptides and Proteins (Growth Factors)
6.	Transforming Growth Factor beta (TGF-beta)
7.	Pentoxifylline (Trental)
8.	Immunoglobulin G (IgG)
9.	Hormones (Hormone)
10.	Proteins (Proteins, Gene)

Related Therapies and Procedures

1.	Therapeutics
2.	Ligation
3.	Drug Therapy (Chemotherapy)