Zyxin

A zinc-binding phosphoprotein that concentrates at focal adhesions and along the actin cytoskeleton. Zyxin has an N-terminal proline-rich domain and three LIM domains in its C-terminal half.

Also Known As:

Networked: 89 relevant articles (0 outcomes, 7 trials/studies)

Bio-Agent Context: Research Results

Experts

1.	Butt, Elke: 5 articles (11/2013 - 11/2004)
2.	Beckerle, Mary C: 4 articles (01/2017 - 01/2003)
3.	Hecker, Markus: 3 articles (01/2022 - 04/2004)
4.	Jensen, Christopher C: 3 articles (01/2017 - 01/2003)
5.	Hoffman, Laura M: 3 articles (09/2014 - 01/2003)
6.	Grunewald, Thomas G P: 3 articles (11/2013 - 04/2006)
7.	Petit, Marleen M R: 3 articles (02/2009 - 01/2005)
8.	Van de Ven, Wim J M: 3 articles (02/2009 - 01/2005)
9.	Al-Hasani, Jaafar: 2 articles (01/2022 - 01/2021)
10.	Ghosh, Subhajit: 2 articles (01/2022 - 01/2021)

Related Diseases

1.	Neoplasms (Cancer) 10/01/2023 - "Overexpression of zyxin in MKN45 cells inhibited tumor growth in nude mice. " 10/01/2023 - "Zyxin also inhibited the proliferation, migration, and invasion but increased the sensitivity of cancer cells to drugs. " 11/01/2020 - "Additionally, zyxin contribution to cancer development is gaining growing interest. " 01/01/2019 - "According to the results, zyxin might play a central role as an upstream regulator to mediate critical cancer-related signaling pathways. " 07/01/2018 - "Thus, more work is required to gain insights into how zyxin modulates cellular functions in relationship to cancer. "
2.	Lipoma (Lipomata) 01/01/2023 - "Here we have characterised the functional properties of lipoma-preferred partner (LPP), a Lin11-Isl1-Mec3 (LIM)-domain protein, which is most closely related to the mechanotransducer zyxin but selectively expressed by smooth muscle cells, including VSMCs in adult mice. " 08/18/2009 - "Among them, the most prominent representatives are zyxin and lipoma preferred (translocation) partner (LPP). " 01/01/2021 - "In terms of homology and structural features, lipoma preferred partner is the nearest relative of zyxin among the LIM domain proteins. " 03/01/2018 - "Lipoma Preferred Partner (LPP) is a member of the zyxin family of LIM proteins that has long been characterized as a promoter of mesenchymal/fibroblast cell migration. " 02/06/2009 - "LPP (Lipoma Preferred Partner) is a zyxin-related cell adhesion protein that is involved in the regulation of cell migration. "
3.	Non-Small-Cell Lung Carcinoma (Carcinoma, Non-Small Cell Lung) 01/01/2022 - "Expression of Zyxin in Non-Small Cell Lung Cancer-A Preliminary Study." 01/01/2019 - "Misregulation of nuclear functions of zyxin appears to be associated with pathogenic effects and diseases, such as prostate cancer and non-small-cell lung cancer. "
4.	Hypoxia (Hypoxemia) 03/31/2016 - "We show that Zyxin is required for TGF-β and hypoxia-induced Lats2 downregulation and deactivation of Hippo signalling in MDA-MB-231 cells. " 03/31/2016 - "In this study, we identify LIM domain protein Zyxin, as a scaffold protein, that in response to hypoxia and TGF-β stimuli, forms a ternary complex with Lats2 and Siah2 and stabilizes their interaction. " 11/01/2017 - "The role of hypoxia, inflammation, and apoptosis in SIDS was demonstrated by exploring some candidate proteins especially APOA1, GAPDH, S100B, zyxin, and complement component C4A. "
5.	Vascular System Injuries 01/01/2021 - "Thus, zyxin-mediated signaling might be a potential treatment target for diseases involving vascular injury." 01/01/2021 - "Conclusion and Implications: This study reveals zyxin as a new player in endothelial repair, which is promoted by forskolin, after vascular injury. " 01/01/2021 - "In this study, we investigated the role of zyxin and its associated cyclic adenosine monophosphate (cAMP) signaling in the regulation of re-endothelialization after vascular injury. "

Related Drugs and Biologics

1.	Proteins (Proteins, Gene)
2.	Tumor Necrosis Factor Receptors (Tumor Necrosis Factor Receptor)
3.	Proline (L-Proline)
4.	Colforsin
5.	Adenosine Monophosphate (AMP)
6.	vasodilator-stimulated phosphoprotein
7.	Vinculin
8.	Integrins
9.	Biomarkers (Surrogate Marker)
10.	Talin

Related Therapies and Procedures

1.	Therapeutics
2.	Ligation
3.	Lasers (Laser)