Wnt3 Protein

A Wnt protein subtype that plays a role in cell-cell signaling during EMBRYONIC DEVELOPMENT and the morphogenesis of the developing NEURAL TUBE. Defects in Wnt3 protein are associated with autosomal recessive tetra-AMELIA in humans.

Also Known As:

Networked: 3 relevant articles (0 outcomes, 0 trials/studies)

Bio-Agent Context: Research Results

Experts

1.	Chen, Chong-Feng: 1 article (07/2017)
2.	Liu, Guo-Sheng: 1 article (07/2017)
3.	Yang, Huai-Cai: 1 article (07/2017)
4.	Denko, Nicholas C: 1 article (09/2015)
5.	Papandreou, Ioanna: 1 article (09/2015)
6.	Verras, Meletios: 1 article (09/2015)

Related Diseases

1.	Disease Progression 01/01/2023 - "We found that increased (P)RR expression in primary CRC lesions is positively associated with higher Wnt3 protein level and disease progression. "
2.	Colorectal Neoplasms (Colorectal Cancer) 01/01/2023 - "We previously found that (pro)renin receptor ((P)RR) augments Wnt3 protein without affecting Wnt3 gene transcription in colorectal cancer (CRC) cells, thus contributes to CRC initiation. "
3.	Infections 07/20/2017 - "The percentages of NSE-positive cells and GFAP-positive cells were significantly higher in NSCs infected with nucleolin-siRNA (P<0.01); the infection also resulted in obviously lowered expression of nestin protein and increased expressions of Wnt3 protein and β-catenin nucleoprotein in the cells. "
4.	Colonic Neoplasms (Colon Cancer) 01/01/2023 - "In colon cancer cells, (P)RR dramatically inhibits the NEDD4L-mediated Wnt3 protein ubiquitination. "
5.	Hypoxia (Hypoxemia) 09/01/2015 - "Previous work from our group showed hypoxia can induce endoplasmic reticulum (ER) stress and block the processing of the WNT3 protein in cells engineered to express WNT3a. "

Related Drugs and Biologics

1.	Nestin
2.	Catenins
3.	Small Interfering RNA (siRNA)
4.	Nucleoproteins
5.	Nucleolin
6.	Prorenin Receptor