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Sodium-Coupled Vitamin C Transporters

Membrane transport proteins that actively co-transport ASCORBIC ACID and sodium ions across the CELL MEMBRANE. Dietary absorption of VITAMIN C is highly dependent upon this class of transporters and a subset of SODIUM GLUCOSE TRANSPORTERS which transport the oxidized form of vitamin C, DEHYDROASCORBIC ACID.
Also Known As:
SLC23A1 Transporter; SLC23A2 Transporter; SVCT 1, Ascorbic Acid Transporter; SVCT 2, Ascorbic Acid Transporter; Sodium-Dependent Vitamin C Transporter; Sodium-Dependent Vitamin C Transporter 1; Sodium-Dependent Vitamin C Transporter 2; Solute Carrier Family 23 (Nucleobase Transporters), Member 1; Solute Carrier Family 23 (Nucleobase Transporters), Member 2; Sodium Coupled Vitamin C Transporters; Sodium Dependent Vitamin C Transporter; Sodium Dependent Vitamin C Transporter 1; Sodium Dependent Vitamin C Transporter 2; Transporter, SLC23A1; Transporter, SLC23A2
Networked: 22 relevant articles (0 outcomes, 2 trials/studies)

Bio-Agent Context: Research Results

Experts

1. Iguchi, Takuma: 3 articles (09/2012 - 10/2007)
2. Wu, Ximei: 3 articles (09/2012 - 10/2007)
3. Hong, Seung-Woo: 2 articles (01/2021 - 01/2016)
4. Jin, Dong-Hoon: 2 articles (01/2021 - 01/2016)
5. Moon, Jai-Hee: 2 articles (01/2021 - 01/2016)
6. Shin, Jae-Sik: 2 articles (01/2021 - 01/2016)
7. Gess, Burkhard: 2 articles (01/2017 - 02/2011)
8. Young, Peter: 2 articles (01/2017 - 02/2011)
9. Itoh, Norio: 2 articles (01/2008 - 10/2007)
10. Nakanishi, Tsuyoshi: 2 articles (01/2008 - 10/2007)

Related Diseases

1. Colonic Neoplasms (Colon Cancer)
2. Alzheimer Disease (Alzheimer's Disease)
3. Breast Neoplasms (Breast Cancer)
10/30/2023 - "Ascorbate Uptake and Retention by Breast Cancer Cell Lines and the Intracellular Distribution of Sodium-Dependent Vitamin C Transporter 2."
03/21/2013 - "Here, we demonstrate that L-ascorbate has a selective killing effect, which is influenced by sodium-dependent vitamin C transporter 2 (SVCT-2) in human breast cancer cells. "
05/01/2005 - "Also upregulated at most ages examined were the sodium-dependent vitamin C transporter, tripartite motif protein 27, aquaporin 4, lipocalin-interacting membrane receptor, and the breast cancer-resistance protein (ABCG2). "
10/05/2019 - "In particular, Organic Anion Transporting Polypeptides 1A2 (OATP1A2) and 2B1 (OATP2B1), Organic Cation Transporter 1 (OCT1), Novel Organic Cation Transporter 1 (OCTN1), Concentrative Nucleoside Transporters 1, 2 and 3 (CNT1, CNT2 and CNT3), Peptide Transporter 2 (PEPT2), Sodium-dependent Vitamin C Transporter 2 (SVCT2), Multidrug Resistance-associated Protein 5 (ABCC5) and Breast Cancer Resistance Protein (ABCG2) are highly induced during lactation. "
12/01/2010 - "Compared with male wild-type mice, HNF4a-HNull male mouse livers had (1) markedly lower messenger RNAs (mRNAs) encoding the uptake transporters sodium taurocholate cotransporting polypeptide, organic anion transporting polypeptide (Oatp) 1a1, Oatp2b1, organic anion transporter 2, sodium phosphate cotransporter type 1, sulfate anion transporter 1, sodium-dependent vitamin C transporter 1, the phase II enzymes Uridine 5'-diphospho (UDP)-glucuronosyltransferase (Ugt) 2a3, Ugt2b1, Ugt3a1, Ugt3a2, sulfotransferase (Sult) 1a1, Sult1b1, Sult5a1, the efflux transporters multidrug resistance-associated protein (Mrp) 6, and multidrug and toxin extrusion 1; (2) moderately lower mRNAs encoding Oatp1b2, organic cation transporter (Oct) 1, Ugt1a5, Ugt1a9, glutathione S-transferase (Gst) m4, Gstm6, and breast cancer resistance protein; but (3) higher mRNAs encoding Oatp1a4, Octn2, Ugt1a1, Sult1e1, Sult2a2, Gsta4, Gstm1-m3, multidrug resistance protein (Mdr) 1a, Mrp3, and Mrp4. "
4. Neoplasms (Cancer)
5. Choriocarcinoma

Related Drugs and Biologics

1. Ascorbic Acid (Vitamin C)
2. Cetuximab (Erbitux)
3. Proteins (Proteins, Gene)
4. Multidrug Resistance-Associated Proteins
5. Peptides (Polypeptides)
6. Anions
7. Lipocalins
8. Aquaporin 4
9. Sodium-Phosphate Cotransporter Proteins (Sodium-Phosphate Cotransporter)
10. Organic Cation Transporter 1