Tetraspanin 29

A subtype of tetraspanin protein that plays a role in cell adhesion, cell motility, and tumor metastasis. It functions in platelet activation and aggregation, the formation of paranodal junctions in neuronal tissue, and the fusion of sperm with egg.

Also Known As:

27 kDa Diphtheria Toxin Receptor-Associated Protein; CD9 Antigen; DRAP27 Protein; Leukemia-Associated Cell Surface Antigen p24; Motility-Related Protein-1; Tetraspanin-29; p24-CD9 Antigen; 27 kDa Diphtheria Toxin Receptor Associated Protein; Antigen, CD9; CD9 Antigens; Leukemia Associated Cell Surface Antigen p24; Motility Related Protein 1; p24 CD9 Antigen; Antigens, CD9

Networked: 44 relevant articles (0 outcomes, 2 trials/studies)

Bio-Agent Context: Research Results

Experts

1.	Dzudzilo, Madara: 1 article (11/2021)
2.	Franckevica, Ivanda: 1 article (11/2021)
3.	Kleina, Regīna: 1 article (11/2021)
4.	Svirskis, Šimons: 1 article (11/2021)
5.	Čēma, Ingrīda: 1 article (11/2021)
6.	Chen, Di: 1 article (01/2021)
7.	Cheng, Liming: 1 article (01/2021)
8.	Han, Qiang-Qiang: 1 article (01/2021)
9.	Li, Shu-Sheng: 1 article (01/2021)
10.	Yan, Jingjun: 1 article (01/2021)

Related Diseases

1.	Neoplasms (Cancer) 03/01/2014 - "Role of motility-related protein-1 in promoting the development of several types of cancer (Review)." 02/01/2011 - "These results suggest that CD9 antigen should play a similar functional role in swine and human and therefore studies on CD9 on swine as an animal model would allow new knowledge about its role in adhesion, fertilization and tumor metastasis among other important biomedical processes." 10/15/2003 - "Motility-related protein 1 (MRP-1/CD9) expression in urothelial bladder carcinoma and its relation to tumor recurrence and progression." 10/01/2001 - "Expression of CD9/motility-related protein 1 (MRP-1) in renal parenchymal neoplasms: consistent expression in papillary and chromophobe renal cell carcinomas." 03/01/1999 - "Although the mechanisms of action of the transmembrane superfamilies, motility-related protein-1 (MRP-1/CD9) and KAI1/CD82, are not well known, they are reported to suppress the metastasis of several kinds of cancers. "
2.	Neoplasm Metastasis (Metastasis) 02/01/2002 - "In addition, we have also cloned the motility-related protein-1 (MRP-1)/cluster of differentiation 9 (CD9) as a metastasis suppressor molecule. " 11/02/2000 - "Suppression of pulmonary metastasis using adenovirally motility related protein-1 (MRP-1/CD9) gene delivery." 02/01/2011 - "These results suggest that CD9 antigen should play a similar functional role in swine and human and therefore studies on CD9 on swine as an animal model would allow new knowledge about its role in adhesion, fertilization and tumor metastasis among other important biomedical processes." 03/01/1999 - "Although the mechanisms of action of the transmembrane superfamilies, motility-related protein-1 (MRP-1/CD9) and KAI1/CD82, are not well known, they are reported to suppress the metastasis of several kinds of cancers. " 09/15/1995 - "Motility related protein 1 (MRP-1/CD9) expression: inverse correlation with metastases in breast cancer."
3.	Melanoma (Melanoma, Malignant) 07/01/2007 - "To study the expression of neutral endopeptidase (CD10) and motility-related protein-1 (CD9) in malignant melanoma and their clinical significance. " 01/05/1991 - "Sequence and structural comparisons showed extensive similarity of the CD9 antigen with a 237-amino acid molecule described previously as the human melanoma-associated antigen ME491 and a Schistosoma mansoni membrane protein of 218 amino acids. "
4.	Precursor Cell Lymphoblastic Leukemia-Lymphoma (Acute Lymphoblastic Leukemia) 02/01/1994 - "Shedding of CD9 antigen in acute lymphoblastic leukemia." 09/01/1993 - "The CD9 antigen was originally described as a 24 kDa molecule present on B lineage-derived acute lymphoblastic leukemia cells and developing B-lymphocytes. " 04/01/1993 - "The CD9 antigen was originally described as a 24-kDa molecule present on B-lineage-derived acute lymphoblastic leukemia cells and developing B lymphocytes. " 07/01/1990 - "Shedding of CD9 antigen into cerebrospinal fluid by acute lymphoblastic leukemia cells." 01/05/1991 - "The CD9 antigen was described originally as a 24-kDa surface protein of non-T acute lymphoblastic leukemia cells and developing B-lymphocytes. "
5.	Leukemia 04/01/1991 - "The leukemia-associated antigen CD9 is present on a variety of normal cells, with apparent variable expression on normal human fibroblasts. " 09/01/1990 - "We found CD9 antigen expression on the cell surface of megakaryoblastic leukemias as well as MEG-01 and HEL cells. " 06/15/1987 - "CALLA-positive T-cell blasts were more likely to express a p24 leukemia-associated antigen (CD9, 50% versus 8%) and Ia antigens (39% versus 8%) than were CALLA-negative blasts. " 02/01/2007 - "Using in situ hybridization, we measured transcript expression of 2',3'-cyclic nucleotide 3'-phosphodiesterase (CNP), myelin-associated glycoprotein (MAG), transferrin (TF), quaking (QKI), gelsolin, myelin oligodendrocyte glycoprotein, v-erb-b2 erythroblastic leukemia viral oncogene homolog 3, erbb2 interacting protein, motility-related protein-1, SRY-box containing gene 10, oligodendrocyte transcription factor 2, peripheral myelin protein 22, and claudin-11 in both gray and white matter of the anterior cingulate cortex (ACC) in subjects with schizophrenia (n=41) and a comparison group (n=34). "

Related Drugs and Biologics

1.	Neprilysin (Neutral Endopeptidase)
2.	Proteins (Proteins, Gene)
3.	Cadherins (E-Cadherin)
4.	Membrane Proteins (Integral Membrane Proteins)
5.	Antigens
6.	multidrug resistance-associated protein 1
7.	A-factor (Streptomyces)
8.	Heparin-binding EGF-like Growth Factor (HB-EGF)
9.	2',3'-Cyclic Nucleotide 3'-Phosphodiesterase
10.	Myelin-Oligodendrocyte Glycoprotein

Related Therapies and Procedures

1.	Aftercare (After-Treatment)