Slipped Capital Femoral Epiphyses

A developmental deformity in which the metaphysis of the FEMUR moves proximally and anteriorly away from FEMUR HEAD (epiphysis) at the upper GROWTH PLATE. It is most common in male adolescents and is associated with a greater risk of early OSTEOARTHRITIS of the hip.

Also Known As:

Adolescent Coxa Vara; Bilateral Slipped Capital Femoral Epiphyses; Bilateral Slipped Capital Femoral Epiphysis; Epiphysiolysis Capitis Femoris; Slipped Femoral Capital Epiphyses; Unilateral Slipped Capital Femoral Epiphyses; Unilateral Slipped Capital Femoral Epiphysis; Adolescent Coxa Varas; Coxa Vara, Adolescent; Slipped Capital Femoral Epiphysis

Networked: 320 relevant articles (7 outcomes, 25 trials/studies)

Relationship Network

Disease Context: Research Results

Musculoskeletal Diseases: 719
- Bone Diseases: 5863
  - Developmental Bone Diseases: 153
    - Osteochondrodysplasias: 592
      - Slipped Capital Femoral Epiphyses: 320
  - Slipped Epiphyses: 75
    - Slipped Capital Femoral Epiphyses: 320

Related Diseases

1.	Legg-Calve-Perthes Disease (Perthes Disease)
2.	Femoracetabular Impingement
3.	Congenital Abnormalities (Deformity)
4.	Osteonecrosis (Kienbock's Disease)
5.	Coxa Vara

Experts

1.	Kim, Young-Jo: 6 articles (04/2020 - 09/2005)
2.	Millis, Michael B: 6 articles (04/2020 - 10/2004)
3.	Nho, Shane J: 3 articles (01/2022 - 09/2013)
4.	Kasser, James R: 3 articles (10/2014 - 09/2005)
5.	Ilharreborde, Brice: 2 articles (01/2022 - 10/2018)
6.	Trousdale, Robert T: 2 articles (10/2021 - 12/2010)
7.	Ramachandran, Manoj: 2 articles (07/2021 - 03/2013)
8.	Fayyad, Tamer A: 2 articles (06/2020 - 05/2020)
9.	Novais, Eduardo N: 2 articles (04/2020 - 08/2016)
10.	Wylie, James D: 2 articles (04/2020 - 02/2015)

Drugs and Biologics

Drugs and Important Biological Agents (IBA) related to Slipped Capital Femoral Epiphyses:

1.	ElementsIBA 09/01/2015 - "Geometrical and mechanical factors that influence slipped capital femoral epiphysis: a finite element study." 05/01/2006 - "Proximal femoral physis shear in slipped capital femoral epiphysis--a finite element study." 04/01/2015 - "Multi-scale finite element model of growth plate damage during the development of slipped capital femoral epiphysis."
2.	Growth Hormone (Somatotropin)IBA 01/01/1996 - "We examined the association between slipped capital femoral epiphysis (SCFE) and growth hormone (GH) treatment in 16,514 children who had not been treated with GH prior to their enrollment in the National Cooperative Growth Study. " 01/01/1996 - "Slipped capital femoral epiphysis in children treated with growth hormone. " 01/01/1996 - "The increased number of treatment with growth hormone is certainly a risk factor for slipped capital femoral epiphysis. " 01/01/1996 - "The authors report two cases of children treated with growth hormone who had a secondary slipped capital femoral epiphysis. " 03/01/1994 - "Patients vary in age from newborn infant to teenager, nevertheless slipped capital femoral epiphysis is probably the most common hip disease during adolescence, and is often associated with endocrine imbalance including growth hormone deficiency. "
3.	Hormones (Hormone)IBA 01/01/2007 - "Potential influence of hormones in the development of slipped capital femoral epiphysis: a preliminary study." 03/01/2008 - "Case report: bilateral slipped capital femoral epiphyses and hormone replacement." 06/05/2004 - "Slipped capital femoral epiphyses associated with the withdrawal of a gonadotrophin releasing hormone." 01/01/1989 - "Hormone status in patients with slipped capital femoral epiphysis." 01/01/1977 - "The effects of various hormones on the physis are specifically discussed, especially as they relate to the possible etiology of slipped capital femoral epiphysis."
4.	TitaniumIBA 03/01/2008 - "[Comparison of the treatment of slipped capital femoral epiphysis with K-wires and cannulated titanium screws]." 08/01/2006 - "Complications at screw removal in slipped capital femoral epiphysis treated by cannulated titanium screws." 01/01/1996 - "Pin removal in slipped capital femoral epiphysis: the unsuitability of titanium devices." 09/01/1993 - "A retrospective review of patients treated for slipped capital femoral epiphysis (SCFE) by in situ screw fixation with a cannulated titanium screw was performed. " 06/01/2002 - "This study compared cannulated 4.5-mm bioabsorbable screws made of self-reinforced poly-levolactic acid to cannulated 4.5-mm steel and titanium screws for resistance to shear stress and ability to generate compression in a polyurethane foam model of slipped capital femoral epiphysis fixation. "
5.	Thyroid HormonesIBA 01/01/2022 - "Slipped capital femoral epiphysis (SCFE) has a well-documented association with underlying endocrine conditions, including thyroid hormone aberrations and parathyroid dysfunction. " 01/01/1988 - "Thyroid hormone levels in patients with slipped capital femoral epiphysis." 09/01/1984 - "This association seems to occur more commonly than the general incidence of slipped capital femoral epiphysis or of juvenile hypothyroidism would suggest, and the thyroid hormone deficiency and a diminished strength of the epiphyseal growth plate of the upper femur appear to be associated. " 09/01/1980 - "Patients receiving growth hormone or thyroid hormone are likely to develop a slipped capital femoral epiphysis during the period of spurt in growth. " 05/01/2017 - "For example, its classification as a biosynthetic drug, the phases that need to be performed in Mexico to verify its safety (obtaining, purification, preclinical studies, clinical trials, and finally observational clinical studies), as well as the evidence that exists in relation to the association of intracranial hypertension, muscular events, scoliosis, slipped capital femoral epiphysis, obstructive sleep apnea, pancreatitis, alterations in cortisol, thyroid hormones alterations, cardiovascular disease, metabolic risk, mortality and cancer, adverse events not related to its use, and finally dosing and safety. "
6.	Vitamin D FDA LinkGeneric 06/01/2022 - "The aim of the study is to find the correlation between vitamin D level and the severity of slippage and bilateral development in slipped capital femoral epiphysis (SCFE) cases if any. " 12/01/2010 - "The early detection and proper treatment of vitamin D may assist in the treatment of patients with slipped capital femoral epiphysis." 12/01/2010 - "Given vitamin D's role in bone and growth plate mineralization and regulation, we hypothesized that vitamin D deficiency would lead to higher rates of fractures, slipped capital femoral epiphysis (SCFE), and Blount disease in obese youth. " 09/01/2021 - "A search of the PubMed database was completed using the following terms: bone health, Vitamin D, pediatric, adolescent, sports medicine, fractures, spine, scoliosis, race, ethnicity, obesity, Slipped Capital Femoral Epiphysis, Osteogenesis Imperfecta, Duchenne's Muscular Dystrophy, neuromuscular, and cancer. " 12/01/2010 - "Vitamin D plays an important role in bone formation and development, but the level of 25-hydroxyvitamin D is not routinely measured during assessment and treatment of slipped capital femoral epiphysis patients. "
7.	Hydrocortisone (Cortisol)FDA LinkGeneric 05/01/2017 - "For example, its classification as a biosynthetic drug, the phases that need to be performed in Mexico to verify its safety (obtaining, purification, preclinical studies, clinical trials, and finally observational clinical studies), as well as the evidence that exists in relation to the association of intracranial hypertension, muscular events, scoliosis, slipped capital femoral epiphysis, obstructive sleep apnea, pancreatitis, alterations in cortisol, thyroid hormones alterations, cardiovascular disease, metabolic risk, mortality and cancer, adverse events not related to its use, and finally dosing and safety. " 09/01/1988 - "In a prospective study, plasma levels of T3, T4, thyroid stimulating hormone (TSH), cortisol, testosterone, growth hormone, and somatomedin-C were tested in 20 consecutive adolescent patients with slipped capital femoral epiphysis (SCFE) in an effort to identify any occult endocrinopathy. "
8.	GadoliniumIBA 09/01/2011 - "Delayed gadolinium-enhanced magnetic resonance imaging of cartilage (dGEMRIC), after slipped capital femoral epiphysis." 01/01/1992 - "Sonographic applications to osteomyelitis, myositis ossificans, tropic pyomyositis, child abuse, synovitis, and slipped capital femoral epiphyses; MR imaging (including gadolinium-enhanced MR scans) in osteomyelitis, the normal and abnormal physis, physeal bars, normal marrow, Gaucher disease, cancer, dysplasia epiphysealis hemimelica, myositis, tenosynovitis, arthritis, and clubfoot; nuclear imaging in osteomyelitis, tibia valga, limp, and unexplained lower extremity pain; and CT in osteomyelitis, are reviewed. " 09/01/2011 - "The aim of this study was to assess the glycosaminoglycan (GAG) content in hip joint cartilage in mature hips with a history of slipped capital femoral epiphysis (SCFE) using delayed gadolinium-enhanced MRI of cartilage (dGEMRIC). "
9.	AntigensIBA 09/01/2014 - "Slipped capital femoral epiphysis in identical twins: does human leucocyte antigen matter?" 01/01/2000 - "Studies from three different countries have linked the HLA B12 and DR4 antigens with slipped capital femoral epiphysis (SCFE). "
10.	HLA-B12 antigenIBA 09/01/1997 - "These results contradict the previously reported HLA-B12 as the phenotype of patients with slipped capital femoral epiphysis." 01/01/2000 - "Studies from three different countries have linked the HLA B12 and DR4 antigens with slipped capital femoral epiphysis (SCFE). "

Therapies and Procedures

1.	Osteotomy 05/01/2020 - "The aim of the study is to assess the safety and efficacy of Imhäuser osteotomy combined with osteochondroplasty in the treatment of moderate-severe stable slipped capital femoral epiphysis (SCFE) on short-term basis. " 05/01/2020 - "Intertrochanteric Imhäuser osteotomy combined with osteochondroplasty in treatment of moderate-severe stable slipped capital femoral epiphysis: a case series study." 01/01/2020 - "This study aims to evaluate the clinical and radiological outcomes of patients with chronic severe slipped capital femoral epiphysis (SCFE) treated by surgical dislocation and modified Dunn osteotomy (MDO). " 11/01/2018 - "The aims of this study were to evaluate the abductor function in moderate and severe slipped capital femoral epiphysis (SCFE), comparing the results of a corrective osteotomy at the base of the femoral neck and osteoplasty with 1) in situ epiphysiodesis for mild SCFE, 2) contralateral unaffected hips, and 3) hips from healthy individuals. " 06/01/2017 - "All patients undergoing a modified Dunn osteotomy for a slipped capital femoral epiphysis over an 8-year period were included in this study, and all had a severe slip with an open physis. "
2.	Hip Replacement Arthroplasty (Total Hip Replacement) 01/01/2023 - "Early Total Hip Arthroplasty is a Cost-Effective Treatment for Severe Radiographic Slipped Capital Femoral Epiphysis Over an Individual's Lifetime." 12/01/2023 - "We aimed to assess the cumulative risk of total hip arthroplasty (THA) from in situ fixation for slipped capital femoral epiphysis (SCFE) after a follow-up of almost 50 years. " 12/01/2023 - "In situ fixation of slipped capital femoral epiphysis carries a greater than 40% risk of later total hip arthroplasty during a long-term follow-up." 01/01/2023 - "Slipped capital femoral epiphysis (SCFE) causes degenerative changes warranting total hip arthroplasty (THA) in approximately 50% of patients by age 60 years. " 12/31/2020 - "There is limited evidence on the outcomes of Total Hip Arthroplasty (THA) in Slipped Capital Femoral Epiphysis (SCFE) patients. "
3.	External Fixators 11/01/2005 - "Unstable slipped capital femoral epiphysis: reduction by gradual distraction with external fixator. " 11/01/2013 - "We have performed corrective osteotomies for moderate or severe slipped capital femoral epiphysis (SCFE) using an original blade plate (BP) until 2006 and using a hybrid external fixator (EF) since 2007. " 02/01/2011 - "To evaluate the early and middle-term results of in situ single screw fixation and subtrochanteric osteotomy of the femur with external fixator for slipped capital femoral epiphysis (SCFE). " 09/01/2001 - "The authors introduce a technique of proximal femoral osteotomy using three-dimensionally corrective external fixator systems for treatment of Legg-Calvé-Perthes disease and slipped capital femoral epiphysis, and describe the results of 47 hips in 44 children. " 07/01/2017 - "Recently, good results have been reported using external fixator systems for the correction of proximal femoral deformities secondary to slipped capital femoral epiphysis, Perthes' disease in children, and percutaneous proximal femoral osteotomy for coxa vara. "
4.	Conservative Treatment 09/01/2010 - "To evaluate the efficacy of conservative treatment of patients with slipped capital femoral epiphysis (SCFE) and the complications due to the progression of the disease. " 07/01/2013 - "Radiographic evaluation led to the diagnosis of physeal dysplasia with slipped capital femoral epiphysis of the left femur, which did not respond to conservative management. " 04/01/1987 - "In cases of an acute slipped capital femoral epiphysis a first conservative treatment with subsequent correction osteotomy does not seem to be justifiable, because the danger of femoral head necrosis raises drastically. " 04/01/2021 - "We cover the evaluation and treatment of avulsion injuries, stress fractures, slipped capital femoral epiphysis (SCFE), femoroacetabular impingement, developmental dysplasia of the hip, Legg-Calve-Perthes disease, and coxa saltans focusing on minimizing advanced imaging and using conservative therapy when applicable. " 01/01/2000 - "Some of the most possible causes of groin pain include stress fracture of the femoral neck or pubic ramus, Legg-Calvé-Perthes disease, slipped capital femoral epiphysis, acetabular labral tears, iliopectineal bursitis, avulsion fracture, osteitis pubis, strain of the thigh muscles or rectus abdominis, inguinal hernia, ilioinguinal neuralgia, and the 'sports hernia.' Depending on the diagnosis, conservative treatment is often effective."
5.	Orthopedic Procedures 11/01/2022 - "To examine the efficacy of virtual reality (VR) to prepare surgical trainees for a pediatric orthopedic surgery procedure: pinning of a slipped capital femoral epiphysis (SCFE). " 01/01/2007 - "A total of 53 patients and 59 hips treated for the acute slipped capital femoral epiphysis at the Institute for Orthopedic Surgery,Banjica" between 1968-2004 were studied. "