Acute Pain

01/01/2022 - "A desire for relief from acute pain caused by the injury was the most common driver for using opioids in the hospital. "
05/15/2022 - "Opioids, although very effective for acute pain, do not prevent the development of CNP, and are considered as insufficient treatment. "
12/01/2019 - "Randomized controlled trials (RCTs) were sought that compared the efficacy of 2 or more opioid analgesics for acute pain in older patients (≥ 65 years) in the ED. "
03/01/2022 - "Effective and safe management of acute pain in opioid-tolerant patients can be challenging, with higher risks of opioid-induced ventilatory impairment and persistent post-discharge opioid use compared with opioid-naive patients. "
01/01/2020 - "While opioids may sometimes be necessary to provide patients with adequate relief from acute pain after major surgery, the impact of opioids on the quality and safety of surgical care calls for greater scrutiny. "

05/01/2005 - "The purpose of this article is to describe the pharmacology and use of analgesic agents that are most useful in the management of acute pain in the emergency department."
08/19/2021 - "Efficacy with EC1728 has been demonstrated in mice, dogs, and horses, and despite the rapid clearance of EC1728 in cats, analgesic efficacy was demonstrated in an acute pain model after intravenous but not oral dosing. "
09/01/2005 - "Although topical and systemic nonsteroidal anti-inflammatory drugs are effective for acute pain relief, these cannot be recommended in favor of other analgesics. "
06/01/2005 - "Number needed to treat (NNT) values have been recommended and used to assess efficacy of analgesics for acute pain management. "
01/01/2017 - "Future research should focus on improved measurement of acute pain and comparisons of effective analgesic regimens instead of single techniques."

06/01/2007 - "NSAIDs are the most effective treatment for acute pain of moderate intensity in children; however, these drugs should be avoided in patients at increased risk for serious side effects, e.g. "
11/10/2010 - "Review of published, randomized clinical trials and meta-analyses shows that topical NSAIDs are significantly more effective than placebo in relieving acute pain; the pooled average relative benefit was 1.7 (95% confidence interval, 1.5-1.9). "
11/01/2012 - "These data suggest lower dose nano-formulated NSAIDs could be effective for acute pain and may potentially improve safety and tolerability as a result of using a lower overall dose."
01/01/2020 - "However, not all NSAIDs are equally effective for treating different types of acute pain. "
01/01/2012 - "It seems to be a safe and effective drug for acute pain management especially when compared with NSAIDs."

04/19/2006 - "In one trial, there was no difference in the efficacy of sustained-release oral versus parenteral morphine, which suggests that oral morphine should be considered for acute pain. "
05/01/2007 - "Morphine infusions do not alter the neurological outcomes of preterm neonates and may not be effective against acute pain. "
01/01/2021 - "Randomized controlled trials (RCTs) comparing LDK to morphine for acute pain control in the ED were included. "
10/01/2020 - "Acute pain and PTSS share neurobiological pathways, and acute dosage of morphine has been linked to reduced PTSS in naturalistic studies. "
01/01/2020 - "However, few studies have been conducted to examine whether morphine reward is influenced by acute pain and injury. "

06/01/2020 - "Our study suggests that intravenous paracetamol is more effective than oral paracetamol when managing acute pain in the out-of-hospital setting. "
02/01/2012 - "Oral acetaminophen has been shown to be safe and effective in a variety of acute pain models. "
06/01/2015 - "IR/ER HB/APAP is intended for acute pain; its efficacy for relief of CNCP would require further evaluation in an active- or placebo-controlled study. "
07/10/2020 - "The results showed that the treatment used in the study may act as a natural, fast acting, and safe alternative for acute pain relief comparable to acetaminophen."
01/01/2019 - "Studies of intravenous acetaminophen for acute pain in the ED demonstrate mixed results and suffer from small sample sizes and methodological limitations. "

01/01/2023 - "Sub-dissociative dose ketamine (0.1-0.6 mg/kg) is safe and effective for the management of acute pain in the ED. "
05/01/2017 - "Recent literature has suggested that the use of subdissociative dose ketamine (SDDK) may be safe and effective for acute pain. "
05/09/2023 - "Efficacy of Low-dose Ketamine for Control of Acute Pain in the Emergency Setting: A Systematic Review and Meta-analysis of Randomized Controlled Trials."
01/01/2021 - "Efficacy of intranasal ketamine for acute pain management in adults: a systematic review and meta-analysis."
01/01/2019 - "Efficacy of IN ketamine in acute pain management in the ED. "

01/01/2014 - "Evidence for formulation and efficacy for ibuprofen in acute pain."
06/01/2019 - "Studies evaluating ibuprofen for the management of acute pain in children were extracted from the PubMed and MEDLINE database within the period ranging from 1985 through 2017. "
04/06/2016 - "To study the effect of Lanconone® (1000 mg) on acute pain on exertion as compared to the standard of care, Ibuprofen (400 mg). "
01/01/2013 - "Subsequent clinical studies were the basis for ibuprofen being widely accepted for treating painful conditions at high anti-rheumatic doses (≤ 2400 mg/d), with lower doses (≤ 1200 mg/d for ≤ 10 days) for mild-moderate acute pain (e.g. "
11/01/2002 - "Meta-analysis of randomised, double-blind placebo-controlled trials of ibuprofen 400 mg in acute pain, and use of individual patient information were planned to test the hypothesis that ibuprofen is ineffective in women. "

11/01/2012 - "In this multicenter, multiple-dose, multiple-day, randomized, double-blind, parallel-group phase 3 study, we investigated whether lower doses of HPβCD diclofenac delivered as a small volume bolus would be effective for the management of acute pain after abdominal or pelvic surgery. "
10/01/2016 - "Safety and efficacy of low doses of diclofenac on acute pain in the emergency setting."
10/07/2009 - "1) Assess the efficacy of diclofenac for acute pain in children. "
01/01/2023 - "Efficacy and safety of Diclofenac sodium plaster in patients with acute pain of the limbs: a randomized, placebo and active-controlled, double-blind, parallel-group trial."
04/01/2014 - "Efficacy and safety of low dose subcutaneous diclofenac in the management of acute pain: a randomized double-blind trial."

01/01/2018 - "This study included patients ≥18 years diagnosed with acute pain who received at least one tramadol prescription each in one of 1,129 general or 179 orthopedic practices in Germany between January and December 2015 (index date). "
01/01/2018 - "The aim of this study was to analyze tramadol prescription patterns in acute pain patients followed by general practitioners and orthopedists in Germany. "
01/01/1994 - "This article reviews the results of single dose and short term studies of oral tramadol 50, 75, 100 and 150 mg in various acute pain conditions. "
01/01/1994 - "There have been only a few studies of oral or spinal application of tramadol in acute pain states. "
07/01/2020 - "This paper provides a review of the pharmacokinetics (PK) of the IV tramadol dosing regimen being developed in the United States, its abuse potential as documented in the literature, and its safety record in clinical practice, and discusses how IV tramadol may become a useful option for patients in the United States with acute pain."

01/01/2023 - "Outpatient Treatment With Gabapentin in Women With Severe Acute Pain After Cesarean Delivery Is Ineffective: A Randomized, Double-Blind, Placebo-Controlled Trial."
01/01/2014 - "This study reviews five aspects of gabapentin: (1) chemical and structural characteristics; (2) pharmacokinetics and pharmacodynamics; (3) application in acute pain management; (4) adverse effects; and (5) drug safety. "
10/01/2019 - "Gabapentin significantly decreased the postoperative acute pain scores at rest (P=0.001) and on movement (P=0.000) within 24 hours; however, it did not have an effect at 48 hours. "
04/01/2017 - "Gabapentin was used as an adjunct for the management of acute pain in approximately half of enhanced recovery programs. "
03/16/2011 - "There is limited evidence to show that gabapentin is ineffective in acute pain."

01/01/2018 - "These were most helpful in providing analgesia for chronic and acute pain, relieving anxiety and decreasing seizure frequency/severity. "
01/01/2022 - "This review shows that RIB was more effective in controlling acute pain after breast surgery and thoracoscopic surgery than general analgesia. "
08/01/2012 - "We conducted a study to find out whether the use of patient control analgesia (PCA) is effective in controlling acute pain in the emergency department This was a randomized controlled trial conducted in the emergency departments of two tertiary centres over a period of 1 year. "
05/01/2017 - "When used as an adjunct, SDDK administered at 0.3 mg/kg over 15 min resulted in safe and effective analgesia for ≤30 min in patients who presented with acute pain in the ED."
09/29/2023 - "Firstly, we compared the safety and efficacy of IN analgesia to other conventional routes of analgesia to assess if IN analgesia may be an alternative for the management of acute pain in ED. "

01/01/2017 - "Aggressive treatment of acute pain in HZ has the potential to prevent the development of PHN, but the preventive efficacy of supplemental therapy commonly used in clinical practice is controversial. "
05/01/2020 - "Recent studies have shown virtual reality (VR) therapy to be successful in the management of acute pain. "
05/16/2019 - "The aim of this preliminary study is to observe if the therapy set to 5 patients suffering of chronic or acute pain is concordant to the Pharmacogenetic test (PGT) results. "
12/01/2016 - "The animal studies justified the short Tmax value (15min) and the high AUC of MXP, which is important in acute pain therapy. "
01/01/2014 - "To study the possibility of using a paired (test) H-reflex recovery test in the expert assessment of the intensity of acute pain syndromes and in the control of performed therapy. "

12/01/2010 - "The objective of this study was to identify through a review of recent literature the barriers to effective treatment of acute pain and the potential consequences of inadequate pain management. "
05/01/2022 - "Few studies have examined the translation of nurses' knowledge of pain management into clinical practice or how nurses negotiated the bureaucracy of caring to treat patients' acute pain. "
07/01/2021 - "The objective of this study was to determine whether a brief therapeutic conversation would improve patient satisfaction with pain management compared with standard care for adult patients presenting to the ED with moderate to severe acute pain. "
01/01/2021 - "More studies should be carried out to identify acute pain predictors and to develop better strategies of pain management for risk patients."
01/01/2020 - "The purpose of this study was to compare the use of these acute pain protocols with traditional prescribing in regard to pain management efficacy and safety measures.Methods"

05/01/2005 - "Patient-controlled analgesia (PCA) has become the gold standard for acute pain management since it was first introduced 20 years ago, and its merits have been discussed in quite a large number of publications. "
08/01/1990 - "Patient-controlled analgesia (PCA) pumps enhance the efficacy of continuous infusions by allowing the patient to administer bolus doses to control acute pain."
12/01/2017 - "The findings of this study do not favor patient-controlled analgesia over usual ED care for acute pain management."
10/01/2007 - "This qualitative study investigated surgical nurses' perceptions of patient-controlled analgesia as a strategy for managing acute pain in a tertiary care hospital. "
01/01/2022 - "A search of PubMed, MEDLINE, and the Cochrane Database was conducted using the MESH search terms emergency department, patient-controlled analgesia, and acute pain up to September 2021. "

10/01/1975 - "The skillful use of nerve blocks is important as a diagnostic, prognostic, and therapeutic tool in the management of chronic and acute pain problems. "
05/01/2016 - "There is good evidence to show that nerve blocks can be effective in managing the acute pain associated with hip fracture. "
08/16/2011 - "Nerve blockade seems to be effective in reducing acute pain after hip fracture. "
11/01/2020 - "There have been multiple diagnostic accuracy studies, most commonly utilizing diagnostic facet joint nerve blocks and an acute pain model, as Bogduk has proposed. "
08/19/2023 - "Ultrasound-guided genitofemoral nerve blocks offered better acute pain relief and higher patient satisfaction than LIA during femoral arterial access gain and closure. "