Kisspeptins

Intercellular signaling peptides that were originally characterized by their ability to suppress NEOPLASM METASTASIS. Kisspeptins have since been found to play an important role in the neuroendocrine regulation of REPRODUCTION.

Also Known As:

KiSS-1 Metastasis Suppressor; Kisspeptin-1; Metastasis Suppressor KiSS-1; Metastins; KiSS 1 Metastasis Suppressor; KiSS-1, Metastasis Suppressor; Kisspeptin 1; Metastasis Suppressor KiSS 1; Metastasis Suppressor, KiSS-1; Kisspeptin; Metastin

Networked: 865 relevant articles (21 outcomes, 172 trials/studies)

Relationship Network

Bio-Agent Context: Research Results

Amino Acids, Peptides, and Proteins: 1
- Proteins: 484843
  - Neoplasm Proteins: 2
    - Tumor Suppressor Proteins: 1683
      - Kisspeptins: 865
        human KISS1 protein: 37
        acetyl-tyrosyl(46)-hydroxypropyl(47)-threonyl(49)-azaglycyl(51)-methylarginyl(53)-tryptophyl(54)- metastin (46-54): 7
        TAK-683: 4
        kissorphin
        metastin (68-121)
        mouse Kiss1 protein
        mouse kisspeptin-13
        p-271 peptide
        rat Kiss1 protein
        Xenopus KISS1 peptide
        zebrafish Kiss1 protein
        zebrafish kiss2 protein
- Peptides: 82426
  - Intercellular Signaling Peptides and Proteins: 29768
    - Kisspeptins: 865
  - Neuropeptides: 6772
    - Kisspeptins: 865

Experts

1.	Tsukamura, Hiroko: 31 articles (06/2022 - 10/2005)
2.	Dhillo, Waljit S: 30 articles (01/2022 - 11/2006)
3.	Tena-Sempere, Manuel: 28 articles (01/2022 - 01/2006)
4.	Uenoyama, Yoshihisa: 26 articles (06/2022 - 10/2005)
5.	Inoue, Naoko: 20 articles (06/2022 - 01/2009)
6.	Abbara, Ali: 17 articles (01/2022 - 12/2011)
7.	Millar, Robert P: 17 articles (10/2021 - 03/2009)
8.	Smith, Jeremy T: 17 articles (01/2020 - 03/2007)
9.	Ozawa, Hitoshi: 16 articles (01/2022 - 02/2011)
10.	Maeda, Kei-Ichiro: 15 articles (12/2020 - 10/2005)

Related Diseases

1.	AIDS-Related Complex (ARC) 01/01/2021 - "The present study used an optogenetic approach to selectively stimulate ARC kisspeptin neurons and examine the effect on LH surges in mice with different hormonal administrations. " 04/12/2019 - "The present study aimed to examine the existence of a neuronal pathway from the hindbrain ependymocytes to kisspeptin neurons in the arcuate nucleus (ARC) and anteroventral periventricular nucleus (AVPV). " 07/01/2015 - "Despite the widely reported role of AVPV kisspeptin neurons in LH surge generation, this study suggests that both AVPV and ARC populations are essential for normal LH surges and estrous cyclicity. " 07/01/2015 - "In accordance with our previous studies, ARC kisspeptin signaling was critical for normal pulsatile LH secretion in female rats. " 04/01/2015 - "In vitro slice studies have revealed that there are significant differences in the spontaneous firing activity between anteroventral periventricular/periventricular preoptic nucleus (AVPV/PeN) and arcuate nucleus (ARC) kisspeptin (Kiss1) neurons in females. "
2.	Infertility (Sterility) 12/01/2014 - "Kisspeptin is currently being evaluated as a novel therapeutic for women with infertility. " 01/01/2019 - "Understanding their biphasic roles in testis may help to consider kisspeptins as potential pharmacological targets for treating human infertility." 12/01/2023 - "Furthermore, two studies reported that changes in kisspeptin levels may be associated with unexplained infertility and low rates of embryo implantation in women undergoing assisted reproductive technology. " 01/01/2023 - "To enable future studies using transgenic animals to investigate these mechanisms, in the present study our aim was to characterize lactational infertility in mice, and to investigate the effect of removing pup-derived cues on LH secretion, time to ovulation, and kisspeptin immunoreactivity. " 12/01/2022 - "Multiple studies have been conducted and are still exploring the role of kisspeptin as an etiologic factor for PCOS associated with infertility. "
3.	Malnutrition (Nutritional Deficiencies) 03/01/2010 - "Using a rat model, we determined the effects of prenatal undernutrition on the development of the hypothalamic kisspeptin system and evaluated whether the alteration of the kisspeptin system contributes to the delayed onset of puberty induced by prenatal undernutrition. " 06/01/2008 - "Conversely, FSH levels were persistently heightened along continuous kisspeptin infusion, but duration of this response was shortened by undernutrition. " 01/01/2006 - "Recent data, however, strongly suggest a prominent role of KiSS-1 in the metabolic control of fertility, as expression of KiSS-1 gene at the hypothalamus is down-regulated in conditions of negative energy balance and kisspeptin administration is capable of overcoming the hypogonadotropic state observed in undernutrition and disturbed metabolic conditions. " 09/01/2005 - "In addition, we monitored the actions of kisspeptin on food intake and the effects of its chronic administration upon puberty onset in undernutrition. " 09/01/2005 - "Changes in hypothalamic KiSS-1 system and restoration of pubertal activation of the reproductive axis by kisspeptin in undernutrition."
4.	Hyperandrogenism 01/01/2021 - "Our results may help to comprehend the role of kisspeptin in the mechanisms of hyperandrogenism." 01/01/2021 - "Increasing evidences have proposed that kisspeptins may be involved in polycystic ovary syndrome (PCOS) including hyperandrogenism. " 01/01/2021 - "Kisspeptin inactivation confers resistance in hyperandrogenism by inhibiting pro-inflammatory cytokines expressions and apoptosis. " 01/01/2021 - "This work aimed to investigate the effect of kisspeptin in hyperandrogenism induced by testosterone. " 01/01/2023 - "LET-treated mice exhibited hyperandrogenism, and KARKO mice exhibited a significant reduction in the coexpression of kisspeptin and androgen receptor mRNA compared to controls. "
5.	Neoplasms (Cancer) 03/31/2019 - "Wealth of information has helped us to develop a better understanding of the critical roles of Kisspeptin-mediated signaling in different cancers. " 01/01/2013 - "The present review highlights the latest studies regarding the role of Kisspeptins and the KiSS-1 gene in tumor progression and also suggests targeting the KiSS-1/GPR54 system may represent a novel therapeutic approach for cancers. " 09/01/2012 - "Recent studies have demonstrated that Kisspeptin, the product of the metastasis suppressor gene KiSS-1, could have a role in tumor progression and invasion. " 05/01/2010 - "The present study has shown for the first time the presence of kisspeptin-LI in adrenal glands and adrenal tumors." 01/01/2023 - "Editorial: The versatile kisspeptin: advances in cancer, metabolism, and reproduction."

Related Drugs and Biologics

1.	Gonadotropin-Releasing Hormone (GnRH)
2.	Leptin
3.	Insulin (Novolin)
4.	Androgen Receptors (Androgen Receptor)
5.	Messenger RNA (mRNA)
6.	Peptides (Polypeptides)
7.	Glucose (Dextrose)
8.	acetyl- tyrosyl(46)- hydroxypropyl(47)- threonyl(49)- azaglycyl(51)- methylarginyl(53)- tryptophyl(54)- metastin (46-54)
9.	Anti-Mullerian Hormone
10.	Estrogen Receptor alpha

Related Therapies and Procedures

1.	Gastric Bypass (Roux-en-Y Gastric Bypass)
2.	Castration
3.	Gastrectomy
4.	Electrodes (Electrode)
5.	Aftercare (After-Treatment)