Anhedonia

Inability to experience pleasure due to impairment or dysfunction of normal psychological and neurobiological mechanisms. It is a symptom of many PSYCHOTIC DISORDERS (e.g., DEPRESSIVE DISORDER, MAJOR; and SCHIZOPHRENIA).

Also Known As:

Physical Anhedonia; Social Anhedonia; Anhedonia, Physical; Anhedonia, Social; Anhedonias; Anhedonias, Physical; Anhedonias, Social; Physical Anhedonias; Social Anhedonias

Networked: 1740 relevant articles (134 outcomes, 199 trials/studies)

Relationship Network

Disease Context: Research Results

Related Diseases

1.	Major Depressive Disorder (Major Depressive Disorders)
2.	Schizophrenia (Dementia Praecox)
3.	Body Weight (Weight, Body)
4.	Cognitive Dysfunction
5.	Bipolar Disorder (Manic Depressive Psychosis)

Experts

1.	Pizzagalli, Diego A: 21 articles (06/2022 - 11/2008)
2.	Papp, Mariusz: 18 articles (01/2020 - 06/2004)
3.	McIntyre, Roger S: 16 articles (07/2022 - 11/2015)
4.	Leventhal, Adam M: 14 articles (10/2021 - 09/2009)
5.	Felger, Jennifer C: 13 articles (07/2022 - 08/2012)
6.	Markou, Athina: 13 articles (01/2018 - 12/2003)
7.	Miller, Andrew H: 12 articles (07/2022 - 08/2012)
8.	Kennedy, Sidney H: 11 articles (01/2022 - 08/2014)
9.	Carlezon, William A: 11 articles (11/2019 - 11/2006)
10.	Martinotti, Giovanni: 11 articles (11/2019 - 01/2011)

Drugs and Biologics

Drugs and Important Biological Agents (IBA) related to Anhedonia:

1.	Antidepressive Agents (Antidepressants)IBA 01/01/2023 - "The Differential Relation of Emotional, Physical, and Sexual Abuse Histories to Antidepressant Treatment Remission and Persistence of Anhedonia in Major Depression: A CAN-BIND-1 Report." 05/01/2006 - "This study suggests that our chronic stress paradigm can serve as a model of anhedonia, in which antidepressant treatment is selectively effective in animals with a hedonic deficit." 01/01/2019 - "Continued research is warranted to further support the efficacy of mechanistically-distinct antidepressants in treating symptoms of anhedonia in MDD. " 08/01/2009 - "We found that antidepressants retain their therapeutic efficacy in reducing both measured indices of depression-like behavior (learned helplessness and anhedonia), even when neurogenesis is blocked. " 01/01/2023 - "AHR antagonist relieved the anhedonia behaviors but not the algesia behaviors in anhedonia-susceptible mice, whereas an AHR agonist abolished the antidepressant-like effect of TPPU. "
2.	Ketamine FDA LinkGeneric 11/01/2020 - "After adjusting for age, sex, primary diagnosis, concomitant medication, body mass index, and baseline depression severity, there was a statistically significant reduction in symptoms of anhedonia with IV ketamine treatment (F (2, 235.6) = 31.6, p < 0.001). " 10/01/2018 - "Rapid effectiveness of intravenous ketamine for ultraresistant depression in a clinical setting and evidence for baseline anhedonia and bipolarity as clinical predictors of effectiveness." 01/01/2022 - "IV ketamine was effective in reducing symptoms of depression, SI, anxiety, and anhedonia in both cohorts in this large, well-characterized community-based sample of adults with TRD." 11/01/2020 - "Ketamine was effective in improving measures of anhedonia in this large, well-characterized community-based sample of adults with TRD. " 01/01/2021 - "Included studies also suggested improvement in suicidal ideation and anhedonia after ketamine infusion. "
3.	Sucrose (Saccharose)IBA 07/01/2022 - "A significant reduction in anhedonia was observed in the sucrose preference test. " 12/01/2019 - "On D-35, ECP (200 mg/kg) significantly attenuated immobility period of the animals in both forced-swim and tail suspension and improved behavioural parameters in open-field and anhedonia in sucrose feeding tests. " 01/01/2016 - "Administration of IMI for 5 weeks to rats subjected to CMS resulted in a gradual significant reduction of anhedonia measured by sucrose intake, in a majority of animals (CMS IMI-reactive, CMS IMI-R), although about 20 % of rats did not respond to the IMI treatment (CMS IMI non-reactive, CMS IMI-NR). " 02/01/2014 - "Our results showed that a single exposure to CUMS caused a significant reduction in sucrose preference, indicating a state of anhedonia. " 12/28/2009 - "Our results showed that rats submitted to CUMS once showed a significant reduction in locomotion and sucrose preference which indicate a state of anhedonia. "
4.	agomelatine (S20098)IBA 11/01/2016 - "Agomelatine was shown to be effective on anhedonia, depression, and anxiety in subjects with major depression. " 01/01/2011 - "Moreover, this is the first study where agomelatine was effective in the treatment of anhedonia. " 01/01/2017 - "Effectiveness of agomelatine on anhedonia in depressed patients: An outpatient, open-label, real-world study." 11/01/2016 - "The aim of this real-world study was to evaluate the effect of agomelatine on anhedonia as primary endpoint in outpatients under treatment of major depressive episodes. " 11/01/2016 - "Effectiveness of agomelatine on anhedonia in depressed patients: an outpatient, open-label, real-world study."
5.	VortioxetineIBA 01/01/2021 - "Vortioxetine showed significant short-term efficacy against anhedonia in this large population of patients with MDD. " 01/01/2019 - "Vortioxetine significantly improved anhedonia as evidenced by significant baseline to endpoint improvements in SHAPS and MADRS anhedonia factor scores (p < 0.0001). " 01/01/2023 - "Data from both studies confirm the safety and efficacy of flexibly dosed vortioxetine over 52 weeks of treatment and demonstrate that MADRS anhedonia factor scores continue to improve with long-term maintenance treatment." 01/01/2021 - "In the placebo-controlled studies, improvements in functioning associated with vortioxetine appeared to be mostly driven by the effect of treatment on MADRS anhedonia factors." 08/30/2023 - "Vortioxetine treatment had a particularly strong effect on the level of social anhedonia. "
6.	Brain-Derived Neurotrophic Factor (BDNF)IBA 11/01/2018 - "These results suggested that EET was equally effective in reversing anhedonia and inducing hippocampal BDNF transcription, but was more effective during ED in inducing frontal cortex BDNF transcription and for lasting anti-anhedonic and BDNF effects particularly in promoter IV-BDNF deficiency." 01/01/2021 - "In the present study, we aimed to investigate the interplay of DNA methylation of different BDNF exons and the common Val66Met polymorphism on anhedonia, reward learning and cognitive performance in MDD. " 01/01/2020 - "The aim of this study was to investigate the dysfunction of brain-derived neurotrophic factor (BDNF) metabolism, measured by the ratio of mature BDNF to precursor-BDNF, in MDD patients with severe anhedonia. " 11/01/2018 - "The effect of enriched environment across ages: A study of anhedonia and BDNF gene induction." 11/01/2023 - "Reductions of BDNF levels may be key neurobiological markers of susceptibility to stress-induced anhedonia."
7.	Fluoxetine (Prozac)FDA LinkGeneric 04/17/2023 - "Treatment with fluoxetine 10 mg/kg significantly improved GJIC and anhedonia of rats until six days. " 10/12/2021 - "Finally, this study suggests that short daily exposure to environmental enrichment improves the effects of fluoxetine to reverse the deterioration of the coat and anhedonia in chronically stressed mice. " 10/12/2021 - "Our results indicate that fluoxetine reversed anhedonia. " 10/12/2021 - "Short Daily Exposure to Environmental Enrichment, Fluoxetine, or Their Combination Reverses Deterioration of the Coat and Anhedonia Behaviors with Differential Effects on Hippocampal Neurogenesis in Chronically Stressed Mice." 01/01/2016 - "We assessed fluoxetine's effects on motivated behaviors in pubescent female hamsters - anhedonia in the reward investigational preference (RIP) test as well as anxiety in the anxiety-related feeding/exploration conflict (AFEC) test. "
8.	Selective Serotonin Reuptake Inhibitors (Serotonin Reuptake Inhibitors)IBA 10/15/2012 - "Therefore TRIs are believed to have faster therapeutic onset than SSRIs, and may be particularly useful for the treatment of anhedonia (i.e. " 03/01/2010 - "The ability of SSRIs to decrease neural responses to reward might underlie the questioned efficacy of SSRIs in depressive conditions characterized by decreased motivation and anhedonia and could also account for the experience of emotional blunting described by some patients during SSRI treatment." 01/01/2015 - "Anhedonia in depressed patients on treatment with selective serotonin reuptake inhibitor anti-depressant--A two-centered study in Malaysia." 09/03/2008 - "We found that male offspring exposed to stress early in gestation displayed maladaptive behavioral stress responsivity, anhedonia, and an increased sensitivity to selective serotonin reuptake inhibitor treatment. " 01/01/2008 - "Case #3: A 28-year-old male with persistent loss of libido, genital anesthesia, and ejaculatory anhedonia since taking several different SSRIs over a 2-year period from 2003-2005. "
9.	Nicotine FDA Link 09/01/2004 - "Nicotine administration is associated with a significant reduction in anhedonia, a near-significant increase in response to financial incentive, enhanced ability to inhibit reflexive eye movements, and increased attentional bias to words with appetitive significance. " 01/01/2014 - "These data suggest that OXY-based medications may be useful for treating the somatic component of the nicotine withdrawal syndrome, but may not be effective in attenuating withdrawal-induced anhedonia. " 01/01/2018 - "Our study has contributed to the understanding of the mechanisms involved in stress- and nicotine-induced disorders, such as anhedonia and memory disturbances." 10/01/2017 - "The present study compared the severity of precipitated withdrawal during chronic infusion of nicotine alone or nicotine-dose equivalent concentrations of three different EC refill liquids in rats, as indicated by elevations in intracranial self-stimulation (ICSS) thresholds (anhedonia-like behavior). " 01/01/2015 - "The goal of this study was to determine the minimal duration of continuous nicotine infusion required to demonstrate nicotine withdrawal in rats as measured by elevations in intracranial self-stimulation (ICSS) thresholds (anhedonia-like behavior). "
10.	Venlafaxine Hydrochloride (Effexor)FDA LinkGeneric 11/01/2013 - "However, venlafaxine treated male rats exhibited better improved explore behavior and anhedonia. " 08/01/2012 - "The primary aim of the present study was to compare the effects of agomelatine (AGO) and venlafaxine XR (VLX) on anhedonia in patients with major depressive disorder. " 08/01/2012 - "Agomelatine versus venlafaxine XR in the treatment of anhedonia in major depressive disorder: a pilot study." 01/01/2012 - "Two studies have described the efficacy of agomelatine in the treatment of anhedonia: an open-label study and a comparative trial versus the antidepressant venlafaxine XR. " 01/01/2017 - "In the CMS rat model, S 47445 (from 1 mg/kg) demonstrated a rapid onset of effect on anhedonia compared to venlafaxine and imipramine. "

Therapies and Procedures

1.	Therapeutics 11/01/2023 - ".These results indicate that DRN-TUS has safely and effectively improved depression-like behaviors including anhedonia and hopelessness, potentially by reversing the depletion of 5-TH.SignificanceTUS may provide a new perspective on depression therapy, possibly through restoring monoamine levels." 01/01/2017 - "Key symptoms of these disorders are anhedonia and correction of which will indicate the efficacy of proposed therapy. " 01/01/2022 - "These include a need for 1) appropriately controlled clinical trials, especially those embracing an experimental therapeutics approach to probe target engagement; 2) novel preclinical models relevant to anhedonia, with stronger translational value; and 3) clinical scales that incorporate neuroscientific advances in our understanding of anhedonia. " 01/01/2021 - "However, novel trial designs incorporating established targets in the brain and/or periphery using relevant outcome variables (e.g., anhedonia) are the future of targeted therapy in psychiatry. " 07/01/2023 - "Augmented Depression Therapy (ADepT) has been developed to target anhedonia and wellbeing. "
2.	Transcranial Magnetic Stimulation 01/01/2021 - "Therapeutic efficacy of connectivity-directed transcranial magnetic stimulation on anticipatory anhedonia." 01/01/2021 - "The present study investigated the efficacy of individualized repetitive transcranial magnetic stimulation (rTMS) targeting the left dorsolateral prefrontal cortex (lDLPFC)-nucleus accumbens (NAcc) network on anticipatory anhedonia in depression. " 08/01/2014 - "Anhedonia and reward-circuit connectivity distinguish nonresponders from responders to dorsomedial prefrontal repetitive transcranial magnetic stimulation in major depression." 11/01/2019 - "We included seven studies fulfilling inclusion/exclusion criteria and involving different measures of anticipatory and consummatory anhedonia, as well as different noninvasive brain stimulation interventions (transcranial magnetic stimulation and transcranial direct current stimulation). " 01/01/2021 - "Effects of transcranial magnetic stimulation on anhedonia in treatment resistant major depressive disorder."
3.	Drug Therapy (Chemotherapy) 01/01/2019 - "Among the identified studies, the efficacy of 14 different pharmacotherapies on measures of anhedonia were evaluated, including melatonergic agents (i.e. " 01/01/2019 - "A total of 17 eligible studies were identified (i.e., evaluated the effects of pharmacotherapy on a measure of anhedonia). " 07/01/2023 - "Anhedonia has moved from merely one among several criteria for depression to a transdiagnostic psychopathology which can be understood neurobiologically, assessed quantitatively, and centered as a primary target in research and development of novel pharmacotherapies. " 01/01/2019 - "Electronic databases Cochrane Library (CENTRAL), Ovid MEDLINE, PubMed, PsycINFO, and Google Scholar were searched from inception to June 1, 2018 for longitudinal studies utilizing pharmacotherapy for the treatment of anhedonia in patients with MDD. " 01/01/2014 - "Remedial efforts are those that either (1) permit the individual to tolerate low levels of pleasure without resorting to drug misuse or other maladaptive behaviors that may unhealthily besot pleasure (for example, through normalization, structuring time, or meditation) or (2) counteract anhedonia by enhancing ones capability to experience pleasure (for example, behavioral activation, positive psychology, pharmacotherapy, or pursuit of positive addictions). "
4.	Transcranial Direct Current Stimulation 10/15/2023 - "This study aimed to investigate the tDCS efficacy and identify the predictive role of anhedonia and rumination in response to tDCS in patients with MDD. " 10/15/2023 - "These results provide new evidence that pronounced anhedonia may be a significant clinical predictor of response to tDCS. " 10/15/2023 - "We found that the reduction in HRSD scores after tDCS was significantly associated with anhedonia's baseline values while no relation was found between baseline rumination and tDCS treatment response. " 11/01/2019 - "We included seven studies fulfilling inclusion/exclusion criteria and involving different measures of anticipatory and consummatory anhedonia, as well as different noninvasive brain stimulation interventions (transcranial magnetic stimulation and transcranial direct current stimulation). " 02/26/2024 - "The first aim of present study was to examine efficacy of tDCS for PTSD, depression, anxiety, and anhedonia in patients with PTSD. "
5.	Self Administration (Administration, Self) 01/01/2018 - "This may represent anhedonia which is associated with depressive-like phenotype and palatable food self-administration may serve as a robust behavioral index of anhedonia in the OBX model." 01/01/2023 - "Acute and prolonged withdrawal symptoms were assessed over a period of 3 weeks using a battery of behavioral test, comprised of alcohol self-administration, anhedonia, hyperalgesia, anxiety-like and depressive-like disturbances. " 08/01/2020 - "Higher anhedonia during withdrawal from initial opioid exposure is protective against subsequent opioid self-administration in rats." 08/01/2020 - "The goal of the current study was to evaluate whether the degree of anhedonia experienced during withdrawal from early opioid exposure predicts subsequent vulnerability to opioid self-administration. " 02/01/2018 - "Early-life adversity facilitates acquisition of cocaine self-administration and induces persistent anhedonia."