RNA Isoforms

11/27/2023 - "Transcription start site choice diversifies mRNA isoforms and defines cancer cell behavior."
11/01/2022 - "Here, we describe a novel oncolytic adenovirus, Ixovex-1, that obtains a cancer-selective replication phenotype by modulating the level of expression of the different, alternatively spliced E1B mRNA isoforms. "
01/01/2022 - "Most of the v3 tumors (16 of 19) harbored both v3a and v3b RNA isoforms. "
12/27/2021 - "Identification of an mRNA isoform switch for HNRNPA1 in breast cancers."
01/01/2021 - "This method allows the simultaneous identification of macrophage APA mRNA isoforms integrated with the characterization of nuclear APA events, the identification of the molecular mechanisms involved, as well as the gene expression alterations caused by the cancer-macrophage crosstalk. "

11/18/2019 - "The loss of NQO1 during hypertrophy was rescued by ectopic expression of the distal- but not the proximal- or middle-specific NQO1 mRNA isoforms in the presence of Star-PAP expression, and reverses molecular events of hypertrophy in cardiomyocytes."
04/01/1999 - "Longstanding LV hypertrophy and failure resulting from MI in rats is not associated with altered expression of the most abundant, type V, AC mRNA isoform, whereas that of type VI is decreased. "
01/14/1994 - "During the early phase of hypertrophy, the only alteration is a decrease in the alpha 2 mRNA isoform. "
01/14/1994 - "The alpha 3 isoform (mRNA and protein), which is extremely low in adult heart, is increased up to 2-fold during hypertrophy but accounts for only approximately equal to 5% of the total alpha isoform mRNA. "
01/14/1994 - "In contrast, the alpha 2 isoform (mRNA and protein) is decreased by 35% and up to 61-64% in mild (< 55%) and severe (> 55%) hypertrophy, respectively. "

08/15/1993 - "In this study performed on 97 Chinese patients with APL, the retrotranscriptase/polymerase chain reaction (RT/PCR) was used to evaluate the clinical relevance of the long (L) or short (S) PML-RAR alpha fusion mRNA isoforms and to study minimal residual disease during clinical remission (CR). "

01/01/2017 - "Distinct roles and differential expression levels of Wnt5a mRNA isoforms in colorectal cancer cells."
01/27/2015 - "Interestingly, the ratio of circular to linear RNA isoforms was always lower in tumour compared to normal colon samples and even lower in colorectal cancer cell lines. "
12/28/2016 - "Our results bring new knowledge on alternative splicing in colorectal cancer and suggest a set of mRNA isoforms that could be used for cancer diagnosis and development of treatment methods."
01/01/2013 - "Differential expression of IGF-1 mRNA isoforms in colorectal carcinoma and normal colon tissue."
01/01/2012 - "Expression of various insulin-like growth factor-1 mRNA isoforms in colorectal cancer."

01/01/2013 - "Reduced fibrosis, normal matrix metalloproteinase-2 and tissue inhibitors of metalloproteinase-4 mRNA expression, and increased collagen III isoform mRNA levels (P < 0.05) accompanied improved diastolic function following chronic training. "