Peripheral Nerve Injuries

01/01/2018 - "These results support the notion that KCC2 and GABAA receptor γ2 subunit contribute to NP following peripheral nerve injury and extend the understanding of the analgesic effects of EA on NP."
02/13/2015 - "These results suggest that immune deviation by active immunization with a non-encephalitogenic MBP-derived APL mediates an analgesic effect in animals with peripheral nerve injury. "
12/26/2013 - "Here we ask if sequences unique to e37a influence: the development of abnormal thermal and mechanical sensitivity associated with peripheral nerve injury; and the actions of two other classes of analgesics that owe part or all of their efficacy to Ca(V)2.2 channel inhibition. "
04/01/2013 - "Hence, suppression of the presynaptic NMDAR activity in the primary sensory afferents is an effective approach to attenuate the enhanced glutamatergic response in the spinal first sensory synapse induced by peripheral nerve injury, and presynaptic NMDARs might be a novel target for the development of analgesics."
01/05/2007 - "Peripheral nerve injury increases nNOS expression in fibers in the superficial dorsal horn, some of which likely express p75(NTR), and alpha2-AR agonists may reduce injury-induced sensitization by activation of nNOS in these fibers In contrast, changes in nNOS and M4 receptor location on spinal cord neurons are not responsible for increased analgesic potency of alpha2-AR agonists after nerve injury."

01/01/2018 - "Further understanding of the neurotrophic factors released from veins may help to optimize current procedures for treating recurrent compressive neuropathy and traumatic peripheral nerve injury, and lead to the development of new therapeutic methods using recombinant neurotrophic factors. "
05/15/2001 - "Its usefulness is extended by evidence that neurotrophins, particularly neurotrophin-3 (NT-3), which has been shown to promote spinal axon elongation, can modulate the efficacy of the muscle spindle-motoneurone connection both after peripheral nerve injury and during development. "
02/01/2018 - "Previous studies have demonstrated that Schwann cells transformed from ADSCs can express nerve growth factors, generate nerve fibers and promote axonal regeneration in models of peripheral nerve injury. "
01/01/2018 - "Overall, the present study indicates that peripheral nerve injury can initiate astrocyte activation accompanied with neurotrophin upregulation in the spinal ventral horn. "
03/01/2009 - "Accumulating evidences in animal studies, particularly in peripheral nerve injuries, demonstrated the effectiveness of neurotrophic factors in rescuing injured motoneurons and promoting axon regeneration. "

09/01/2018 - "Schwann cell proliferation was higher in Group 3 than in Group 5. Immunohistochemical changes were significantly lower in Group 4 than in Group 3. Axonal degeneration was also higher in Group 4 than in Group 3. Gabapentin promotes neurological recovery histopathologically in peripheral nerve injury due to its neuroprotective properties. "
10/01/2014 - "Peripheral nerve injury and gabapentin, but not their combination, impair attentional behavior via direct effects on noradrenergic signaling in the brain."
02/05/2007 - "Neurochemical evidence that supraspinally administered gabapentin activates the descending noradrenergic system after peripheral nerve injury."
09/01/2018 - "Our study results show that gabapentin can be used as an adjunctive therapy to primary surgical treatment after peripheral nerve injury."
11/01/1998 - "The present study suggests that gabapentin has preferential antihyperalgesic and/or antiallodynic effects, and is equally effective in pain due to peripheral nerve injuries and central lesions."

08/01/2014 - "Here, the authors compared the efficacy of systemic morphine between normal rats and rats with peripheral nerve injury, with a specific focus on descending serotonergic mechanisms. "
01/01/2021 - "Peripheral nerve injury promotes morphine-seeking behavior in rats during extinction."
11/01/2019 - "Previous preclinical studies have documented exacerbation of nociceptive hypersensitivity, including that induced by peripheral nerve injury, by morphine. "
07/01/2011 - "GPR3 orphan receptor is involved in neuropathic pain after peripheral nerve injury and regulates morphine-induced antinociception."
02/01/2005 - "The degree to which intrathecally administered morphine can alleviate hypersensitivity in animals after peripheral nerve injury is controversial, and the mechanisms by which morphine works in these circumstances are uncertain. "

01/01/1998 - "[The protective effects of nerve growth factor on peripheral nerve injury]."
12/01/2015 - "The aim of this study was to explore the effect of the combination of nerve fragments with nerve growth factor (NGF) on the repair of peripheral nerve injury through autologous epineurium small gap coaptation. "
10/01/1999 - "The positive effects of NGF on regeneration of nerves across a gap seen in this study suggest that it may be useful for treating peripheral nerve injuries in combination with autogenous vein grafts."
07/01/1999 - "Previous studies have shown that NGF levels in the dorsal root ganglia (DRG) fluctuate following a peripheral nerve injury. "
12/01/2023 - "These findings indicated that NGF has therapeutic ability for the treatment of peripheral nerve injuries and virus-based tracers can be used to monitor the recovery."

09/01/1984 - "Further studies are required to elucidate how these peptide changes are related to the adaptive processes which occur centrally following peripheral nerve injury."
08/01/2021 - "However, the role of these two small peptides in peripheral nerve injury remains unclear. "
08/01/2021 - "ISP and PAP4 peptides promote motor functional recovery after peripheral nerve injury."
01/14/2015 - "The fact that peripheral nerve injury induced de novo GRP expression in DRG neurons points to a novel contribution of this peptide to pruritoceptive processing in neuropathic itch conditions. "
01/01/2012 - "C3 peptide promotes axonal regeneration and functional motor recovery after peripheral nerve injury."

01/01/2019 - "The Val66Met BDNF Polymorphism and Peripheral Nerve Injury: Enhanced Regeneration in Mouse Met-Carriers Is Not Further Improved With Activity-Dependent Treatment."
10/01/2022 - "After peripheral nerve injury, exercise training downregulated BDNF expression and reversed microglial activation, as indicated by the increased expression of the M2 marker CD206 and decreased expression of the M1 marker CD86 in the spinal dorsal horn of mice. "
01/01/2022 - "We also demonstrate the feasibility of electrically conductive NGCs based on the rGO/BDNF/GelMA-integrated Morpho butterfly wing as functional nerve regeneration conduits, which may have potential value for application in repairing peripheral nerve injuries."
01/01/2017 - "These results suggested that local BDNF produced by peripheral nerve injury contributes to accelerating sclerotic changes in the alveolar bone."
01/01/2017 - "We reported that peripheral nerve injury promotes the local production of BDNF; therefore, it was possible to hypothesize that peripheral nerve injury affects sclerotic changes in the alveolar bone. "

03/15/2021 - "Peripheral nerve injury in patients exposed to n-hexane: an analysis of eight cases."
11/01/2020 - "We use the detailed physical, neurological examinations, rehabilitation assessment scale, and electrophysiological examinations at hospital admission and six months' follow up to assess the effect of a rehabilitation program on peripheral nerve injury caused by n-hexane nine patients. "
06/01/2009 - "[Therapy experience of severe N-hexane poisoning with peripheral nerve injury]."
08/01/2011 - "ADH could play an important role in the protective effects induced by garlic oil on the peripheral nerve injuries produced by n-hexane."
08/01/2011 - "To study the protective effects of garlic oil (GO) on the peripheral nerve injuries induced by n-hexane. "

08/01/2011 - "ADH could play an important role in the protective effects induced by garlic oil on the peripheral nerve injuries produced by n-hexane."
08/01/2011 - "To study the protective effects of garlic oil (GO) on the peripheral nerve injuries induced by n-hexane. "
01/20/2020 - "[Study on the effect of diallyl sulfide on peripheral nerve injury in n-hexane intoxicated rats]."
11/01/2011 - "To study the role of CYP2E1 in the protective effects and mechanism of garlic oil (GO) on the peripheral nerve injuries induced by n-hexane. "
01/20/2020 - "Objective: To investigate the antagonistic effect of diallyl sulfide (DAS) against peripheral nerve injury induced by n-hexane in rats. "

10/11/2023 - "Conclusion: Electrospun PCL scaffolds with tacrolimus hold promise for the repair of peripheral nerve injury. "
10/11/2023 - "This article reports the production and testing of fibrous materials loaded with tacrolimus, a drug known to improve nerve regeneration, for the surgical repair of peripheral nerve injury. "
01/01/2021 - "Tacrolimus-Induced Neurotrophic Differentiation of Adipose-Derived Stem Cells as Novel Therapeutic Method for Peripheral Nerve Injury."
11/01/2019 - "The aim of this article is to review current evidence regarding the use of tacrolimus in peripheral nerve injuries.Areas"
01/01/2016 - "The combined drug delivery nerve guide can release FK506 for extended periods of time and enhance axon growth, and has the potential to improve nerve regeneration after a peripheral nerve injury."

02/01/2016 - "Skin-derived precursor Schwann cell (SKPSC) therapy has been identified as a potentially beneficial treatment for peripheral nerve injuries. "
01/01/2012 - "The mNGF therapy is effective for peripheral nerve injury. "
03/01/2004 - "Taken together, these data suggest that bone marrow stromal cell therapy is a safe and effective strategy for peripheral nerve injuries."
10/01/2016 - "We also address potential secondary benefits of GH-based therapies pertaining to improved bone, tendon and wound healing in the setting of peripheral nerve injury. "
03/01/2021 - "Cell based therapies provide a novel treatment for peripheral nerve injuries. "

11/01/2018 - "The reconstruction of peripheral nerve injuries is clinically challenging, and today, the autologous nerve transplantation is still considered as the only gold standard remedy for nerve lesions where a direct nerve coaptation is not possible. "
01/01/2016 - "Our results suggest that SKP-SCs transplantation with heregulin-1β represents a powerful therapeutic approach, and facilitates the efficacy of acellular nerve allograft in peripheral nerve injury, though the detailed mechanism remains to be elucidated."
01/12/2015 - "Here, we investigated the therapeutic efficacy of transplantation of BMSCs through targeted muscular injection with small gap neurorrhaphy by scissoring and sleeve-jointing epineurium on repairing peripheral nerve injury in a rat model. "
01/01/2022 - "Peripheral nerve injury is a challenging orthopedic condition that can be treated by autograft transplantation, a gold standard treatment in the current clinical setting. "
03/01/2020 - "Nerve grafting and Schwann cell transplantation have represented the gold standard treatment for peripheral nerve injuries, however these approaches own limitations, such as scarce donor nerve availability and donor site morbidity. "

01/01/2023 - "The use of nerve guidance conduits (NGCs) to treat peripheral nerve injuries is a favorable approach to the current "gold standard" of autografting. "
06/01/2009 - "Autografting is the gold standard in the repair of peripheral nerve injuries that are not amenable to end-to-end coaptation. "
11/19/2019 - "Implantable tubular devices known as nerve guidance conduits (NGCs) have drawn considerable interest as an alternative to autografting in the repair of peripheral nerve injuries. "
05/01/2016 - "Direct repair and nerve autografting are primary options in the treatment of upper extremity peripheral nerve injuries. "
04/15/2003 - "The intrinsic capacity of Schwann cells to promote regeneration after limited peripheral nerve lesions has been successfully transferred to extensive peripheral nerve injuries and central nervous system lesions by autologous transplantation strategies. "

01/01/2023 - "Drug therapies for treating peripheral nerve injury repair have shown significant promise in preclinical studies. "
01/01/2020 - "Therefore, effective drug therapy is needed to promote nerve regeneration in the treatment of peripheral nerve injury. "
01/01/2018 - "Animal models of peripheral nerve injury, diabetes or chemotherapy all demonstrate activation of SGCs, suggesting important physiological roles for SGCs in various states of peripheral neuropathy. "
07/16/2014 - "These models derive from known etiologies, thus reproducing peripheral nerve injuries, central injuries, and metabolic-, infectious- or chemotherapy-related neuropathies. "
01/01/1997 - "Clinically significant peripheral nerve injury will most likely occur if the dose of IORT exceeds 20 Gy. Tolerance of peripheral nerve will also depend on the volume of irradiated nerve and surrounding tissues, such as muscle and vasculature, or the combination of IORT with other therapeutic modalities, such as hyperthermia and chemotherapy. "

07/01/2012 - "Nerve transfers using an expendable nearby motor nerve to reinnervate a denervated nerve have resulted in more rapid and improved functional recovery than traditional nerve graft reconstructions following a peripheral nerve injury. "
12/01/2020 - "Nerve transfers are replacing other techniques as the gold standard for brachial plexus and other proximal peripheral nerve injuries. "
11/21/2023 - "Sensory nerve transfers in the upper limb after peripheral nerve injury: a scoping review."
11/21/2023 - "Key Concepts for Nerve Transfer Rehabilitation After Surgical Reconstruction for Brachial Plexus and Peripheral Nerve Injuries."
09/01/2023 - "Distal Nerve Transfers in Hand and Forearm for Traumatic Brachial Plexus and Peripheral Nerve Injuries: A Narrative Review."