Cerebral Small Vessel Diseases

Pathological processes or diseases where cerebral MICROVESSELS show abnormalities. They are often associated with aging, hypertension and risk factors for lacunar infarcts (see LACUNAR INFARCTION); LEUKOARAIOSIS; and CEREBRAL HEMORRHAGE.

Also Known As:

Cerebral Microangiopathies; Cerebral Small Vessel Disease; Cerebral Microangiopathy; Microangiopathies, Cerebral; Microangiopathy, Cerebral

Networked: 621 relevant articles (14 outcomes, 111 trials/studies)

Relationship Network

Disease Context: Research Results

Related Diseases

1.	Stroke (Strokes)
2.	Hypertension (High Blood Pressure)
3.	Cognitive Dysfunction
4.	Frailty
5.	Atrophy

Experts

1.	Markus, Hugh S: 13 articles (01/2022 - 01/2004)
2.	Wardlaw, Joanna M: 13 articles (01/2021 - 12/2010)
3.	Na, Duk L: 12 articles (01/2022 - 02/2015)
4.	Seo, Sang Won: 11 articles (01/2022 - 02/2015)
5.	Werring, David J: 11 articles (01/2022 - 02/2012)
6.	Kim, Hee Jin: 10 articles (01/2021 - 02/2015)
7.	Dichgans, Martin: 9 articles (01/2022 - 09/2007)
8.	Schmidt, Reinhold: 9 articles (01/2022 - 11/2004)
9.	Viswanathan, Anand: 8 articles (01/2022 - 11/2008)
10.	Charidimou, Andreas: 7 articles (09/2022 - 02/2012)

Drugs and Biologics

Drugs and Important Biological Agents (IBA) related to Cerebral Small Vessel Diseases:

1.	Biomarkers (Surrogate Marker)IBA 07/20/2023 - "EPVSs are important since they serve as a biomarker for cerebral small vessel disease and also represent an impairment of the effluxing glymphatic system that is important for the clearance of metabolic waste from the interstitial fluid to the cerebrospinal fluid, and disposal. " 01/01/2014 - "The aim of this study is to figure out cognitive and biomarker profiles that may help to distinguish between VD, AD and AD + Cerebral Small Vessel Disease (CSVD). " 04/27/2023 - "Biological aging biomarkers, such as leukocyte telomere length (LTL) and epigenetic clocks, have been associated with the risk of cerebral small vessel disease (CSVD) in several observational studies. " 04/27/2023 - "Assessing the Causal Association between Biological Aging Biomarkers and the Development of Cerebral Small Vessel Disease: A Mendelian Randomization Study." 10/01/2022 - "Histogram-based metrics extracted from diffusion-tensor imaging (DTI) have been suggested as potential biomarkers for cerebral small vessel disease (SVD), but methods and results have varied across studies. "
2.	Amyloid (Amyloid Fibrils)IBA 11/24/2020 - "To evaluate the association between brain amyloid β (Aβ) and cerebral small vessel disease (CSVD) markers, as well as their joint effect on cognition, in a memory clinic study. " 11/24/2020 - "Brain amyloid β, cerebral small vessel disease, and cognition: A memory clinic study." 01/01/2017 - "Plasma Amyloid-β Levels, Cerebral Small Vessel Disease, and Cognition: The Rotterdam Study." 11/25/2014 - "Plasma β-amyloid and MRI markers of cerebral small vessel disease: Three-City Dijon study." 01/01/2023 - "Our results showed that (i) fibre density was reduced in genetically defined cerebral small vessel disease and strongly associated with cerebral small vessel disease imaging hallmarks; (ii) fibre-bundle cross-section was mainly associated with brain volume; and (iii) both fibre density and fibre-bundle cross-section were reduced in the presence of amyloid, but not further exacerbated by abnormal tau deposition. "
3.	Antihypertensive Agents (Antihypertensives)IBA 07/30/2021 - "The relation between antihypertensive treatment and progression of cerebral small vessel disease: A systematic review and meta-analysis of randomized controlled trials." 01/01/2018 - "We aimed to study the effect of antihypertensive medication (AHM) on the progression of cerebral small vessel disease. " 01/16/2013 - "Further studies are required to better define the antihypertensive drug regimen and target blood pressure which would be optimal for the prevention of cerebral small vessel disease." 01/01/2022 - "Effect of Antihypertensives by Class on Cerebral Small Vessel Disease: A Post Hoc Analysis of SPRINT-MIND." 01/01/2018 - "Effect of Antihypertensive Medication on Cerebral Small Vessel Disease: A Systematic Review and Meta-Analysis."
4.	Hydroxymethylglutaryl-CoA Reductase Inhibitors (HMG-CoA Reductase Inhibitors)IBA 12/01/2001 - "The results may help to elucidate the preventive effect of statins and provide insights into the pathophysiology of cerebral small-vessel disease." 09/15/2007 - "Recent studies suggest a beneficial effect of statins on cerebral vasoreactivity in patients with cerebral small vessel disease (SVD). " 09/01/2009 - "Statins and gender-related difference in endothelial function in cerebral small vessel disease." 07/01/2005 - "Significant improvements of cerebral vasomotor reactivity during statin treatment were found in patients with cerebral small-vessel disease. " 12/01/2001 - "This pilot study provides the first evidence for a significant improvement of cerebral vasomotor reactivity by statin therapy in patients with cerebral small-vessel disease. "
5.	Nitric Oxide (Nitrogen Monoxide)FDA Link 01/01/2023 - "[Nitric oxide availability in cerebral microangiopathy]." 03/01/2004 - "Endothelial nitric oxide gene haplotypes and risk of cerebral small-vessel disease." 01/01/2023 - "To develop a test of individual nitric oxide (NO) availability based on changes in erythrocyte rheological properties after incubation with a NO donor and to evaluate the role of these disorders in brain damage and development of cognitive impairment (CI) in cerebral small vessel disease (cSVD). " 01/01/2020 - "To assess the association of baseline imaging markers of cerebral small vessel disease (SVD) and brain frailty with clinical outcome after acute stroke in the Efficacy of Nitric Oxide in Stroke (ENOS) trial. "
6.	Tadalafil (Cialis)FDA Link 01/01/2020 - "Increased oxygenation of cerebral microvasculature during tadalafil treatment indicated improved perfusion in the cerebral microvasculature, theoretically presenting an attractive new therapeutic target in cerebral small-vessel disease. " 01/01/2020 - "Future studies of the effect of long-term tadalafil treatment on cerebrovascular reactivity and endothelial function are needed to evaluate general microvascular changes and effects in cerebral small-vessel disease and stroke." 01/01/2020 - "Our findings suggest that tadalafil may improve vascular parameters in patients with cerebral small-vessel disease stroke, although the effect size was small. " 01/01/2020 - "We investigated an approach targeted to the signalling molecule cyclic guanosine monophosphate, using the phosphodiesterase 5 inhibitor tadalafil, to explore if it improves cerebral blood flow and endothelial function in patients with cerebral small-vessel disease and stroke. "
7.	Vascular Endothelial Growth Factor A (Vascular Endothelial Growth Factor)IBA 02/01/2018 - "In conclusion, the results demonstrated that salvianolic acid B recovers cognitive deficits and angiogenesis in the cerebral small vessel disease rat model via STAT3/VEGF signaling pathway." 02/01/2018 - "Salvianolic acid B recovers cognitive deficits and angiogenesis in a cerebral small vessel disease rat model via the STAT3/VEGF signaling pathway." 01/01/2021 - "Histological examination showed improved cerebral microangiopathy, increased expression of claudin-1 and -3, CD31, and VEGF in the cerebral cortical microvasculature and choroid plexus in PE rats treated with omega-3. " 02/01/2018 - "In addition, salvianolic acid B upregulated signal transducer and activator of transcription 3 (STAT3) phosphorylation protein expression, and induced vascular endothelial growth factor (VEGF) and VEGF receptor 2 protein expression in cerebral small vessel disease rats. " 02/24/2015 - "We performed a cross-sectional study relating a panel of 15 biomarkers, representing systemic inflammation (high-sensitivity C-reactive protein, interleukin-6, monocyte chemotactic protein-1, tumor necrosis factor α, tumor necrosis factor receptor 2, osteoprotegerin, and fibrinogen), vascular inflammation (intercellular adhesion molecule 1, CD40 ligand, P-selectin, lipoprotein-associated phospholipase A2 mass and activity, total homocysteine, and vascular endothelial growth factor), and oxidative stress (myeloperoxidase) to ischemic (white matter hyperintensities/silent cerebral infarcts) and hemorrhagic (cerebral microbleeds) markers of cerebral small vessel disease (CSVD) on MRI in 1,763 stroke-free Framingham offspring (mean age 60.2 ± 9.1 years, 53.7% women). "
8.	Claudin-1IBA 01/01/2021 - "Histological examination showed improved cerebral microangiopathy, increased expression of claudin-1 and -3, CD31, and VEGF in the cerebral cortical microvasculature and choroid plexus in PE rats treated with omega-3. "
9.	Cyclooxygenase 2 Inhibitors (COX-2 Inhibitors)IBA 01/01/2015 - "A Cyclooxygenase-2 Inhibitor Reduces Vascular Wall Thickness and Ameliorates Cognitive Impairment in a Cerebral Small Vessel Diseases Rat Model."
10.	Waste Products (Waste Product)IBA 01/01/2022 - "Enlarged PVS (EPVS) are commonly seen in patients with cerebral small vessel disease (CSVD) and have been suggested to reflect dysfunctional perivascular clearance of soluble waste products from the brain. "

Therapies and Procedures

1.	Therapeutics 09/23/2022 - "Mesenchymal Stem Cell-Derived Extracellular Vesicles as Proposed Therapy in a Rat Model of Cerebral Small Vessel Disease." 01/01/2020 - "Monogenic cerebral small-vessel diseases: diagnosis and therapy. " 12/05/2019 - "Mechanism-specific therapies for this aggressive cerebral small vessel disease are lacking. " 01/01/2019 - "Antiplatelet Therapy in Cerebral Small Vessel Disease." 09/01/1985 - "The following conclusions were drawn: In patients with cerebral microangiopathy any procedures aimed at the diagnosis and therapy of major vessel disease are not useful. "
2.	Chinese Traditional Medicine (Traditional Chinese Medicine) 04/01/2022 - "This study aims to analyze the research on the prevention and treatment of cerebral small vessel diseases(CSVDs) with traditional Chinese medicine(TCM) based on knowledge map, and to preliminarily explore the research hotspots and trends. " 01/01/2022 - "Taken together, these findings demonstrated the role of BSHX in the management of diabetic cerebral microangiopathy and provide some insights into the proteomics-guided pharmacological mechanism study of traditional Chinese Medicine." 04/01/2022 - "[Analysis of CiteSpace knowledge map for traditional Chinese medicine prevention and treatment of cerebral small vessel diseases]." 01/01/2022 - "Cerebral small vessel disease (CSVD) is often referred to as "collaterals disease" in traditional Chinese medicine (TCM), and commonly includes ischemic and hemorrhagic CSVD. " 01/01/2022 - "A Review of Traditional Chinese Medicine, Buyang Huanwu Decoction for the Treatment of Cerebral Small Vessel Disease."
3.	Tai Ji (Tai Chi Chuan) 01/01/2021 - "Evaluation of eight-style Tai chi on cognitive function in patients with cognitive impairment of cerebral small vessel disease: study protocol for a randomised controlled trial."
4.	Thrombectomy 03/13/2023 - "Total Cerebral Small Vessel Disease Burden Predicts the Outcome of Acute Stroke Patients after Intra-Arterial Thrombectomy." 11/09/2022 - "To investigate the association between the overall cerebral small vessel disease (CSVD) burden and the therapeutic outcome of mechanical thrombectomy (MT) in patients with acute anterior circulation large-vessel occlusion stroke. " 11/09/2022 - "Overall cerebral small vessel disease burden is associated with outcome of acute ischemic stroke after mechanical thrombectomy." 09/01/2022 - "To determine the influence of the cerebral small vessel disease (SVD) burden on collateral recruitment in patients treated with mechanical thrombectomy (MT) for anterior circulation acute ischemic stroke (AIS). " 02/04/2021 - "Severe Cerebral Small Vessel Disease Burden Is Associated With Poor Outcomes After Endovascular Thrombectomy in Acute Ischemic Stroke With Large Vessel Occlusion."
5.	Secondary Prevention 01/01/2021 - "Potential recruitment into a clinical trial of vascular secondary prevention medications in cerebral small vessel disease, based on concomitant medication use." 02/28/2022 - "The imaging of cerebral small vessel disease with atrial fibrillation has a potential relationship with cognitive function decline and is related to the occurrence and prognosis of stroke, even more has a potential role in suggesting the etiology and secondary prevention strategies of ischemic stroke. " 01/01/2021 - "Prevalence and Effect of Cerebral Small Vessel Disease in Stroke Patients With Aspirin Treatment Failure-A Hospital-Based Stroke Secondary Prevention Registry."