Class Ib Phosphatidylinositol 3-Kinase

A phosphatidylinositol 3-kinase subclass that includes enzymes formed through the association of a p110gamma catalytic subunit and one of the three regulatory subunits of 84, 87, and 101 kDa in size. This subclass of enzymes is a downstream target of G PROTEIN-COUPLED RECEPTORS.

Also Known As:

Class Ib Phosphatidylinositol 3-Kinase, p101 Subunit; Class Ib Phosphatidylinositol 3-Kinase, p110gamma Subunit; Class Ib Phosphatidylinositol 3-Kinase, p84 Subunit; Class Ib Phosphatidylinositol 3-Kinase, p87 Subunit; Phosphatidylinositol 3-Kinase, Class Ib; Phosphoinositide-3-Kinase, Catalytic, gamma Polypeptide; Phosphoinositide-3-Kinase, Regulatory Subunit 5; p101 Subunit, Phosphoinositide-3-Kinase; p110gamma Subunit, Class Ib Phosphatidylinositol 3-Kinase; p84 Subunit, Class Ib Phosphatidylinositol 3-Kinase; p87 Subunit, Class Ib Phosphatidylinositol 3-Kinase; Class Ib Phosphatidylinositol 3 Kinase; Class Ib Phosphatidylinositol 3 Kinase, p101 Subunit; Class Ib Phosphatidylinositol 3 Kinase, p110gamma Subunit; Class Ib Phosphatidylinositol 3 Kinase, p84 Subunit; Class Ib Phosphatidylinositol 3 Kinase, p87 Subunit; Class Ib Phosphatidylinositol 3 Kinases; Phosphatidylinositol 3 Kinase, Class Ib; Phosphoinositide 3 Kinase, Regulatory Subunit 5; Phosphoinositide-3-Kinase p101 Subunit; Subunit, Phosphoinositide-3-Kinase p101; p101 Subunit, Phosphoinositide 3 Kinase; p110gamma Subunit, Class Ib Phosphatidylinositol 3 Kinase; p84 Subunit, Class Ib Phosphatidylinositol 3 Kinase; p87 Subunit, Class Ib Phosphatidylinositol 3 Kinase; Class Ib Phosphatidylinositol 3-Kinases

Networked: 3 relevant articles (0 outcomes, 1 trials/studies)

Bio-Agent Context: Research Results

Experts

1.	Jing, Bo: 1 article (07/2019)
2.	Khalique, Abdul: 1 article (07/2019)
3.	Naqash,: 1 article (07/2019)
4.	Ni, Xueqin: 1 article (07/2019)
5.	Pan, Kangcheng: 1 article (07/2019)
6.	Qing, Xiaodan: 1 article (07/2019)
7.	Shoaib, Muhammad: 1 article (07/2019)
8.	Shu, Gang: 1 article (07/2019)
9.	Wang, Hesong: 1 article (07/2019)
10.	Xin, Jinge: 1 article (07/2019)

Related Diseases

1.	Neoplasms (Cancer) 01/01/2017 - "The purpose of the present study was to determine whether protein phosphatase Mg2+/Mn2+ dependent 1D, β-1,3-N-acetylglucosaminyltransferase, neural precursor cell expressed, developmentally down-regulated 9, prohibitin, phosphoinositide-3-kinase regulatory subunit 5 (PIK3R5), phosphatidylinositol-5-phosphate 4-kinase type IIα, TRF1-interacting ankyrin-related ADP-ribose polymerase 2, BCL2 associated agonist of cell death, G2 and S-phase expressed 1 and PAX interacting protein 1 genes, described as prognostic markers in breast cancer in a previous microarray study, are also predictors of lymph node involvement in breast carcinoma Reverse transcription-quantitative polymerase chain reaction analysis was performed on primary breast tumor tissues from women with negative lymph node involvement (n=27) compared with primary tumor tissues from women with positive lymph node involvement (n=23), and was also performed on primary tumors and paired lymph node metastases (n=11). "
2.	Lymphatic Metastasis 01/01/2017 - "The purpose of the present study was to determine whether protein phosphatase Mg2+/Mn2+ dependent 1D, β-1,3-N-acetylglucosaminyltransferase, neural precursor cell expressed, developmentally down-regulated 9, prohibitin, phosphoinositide-3-kinase regulatory subunit 5 (PIK3R5), phosphatidylinositol-5-phosphate 4-kinase type IIα, TRF1-interacting ankyrin-related ADP-ribose polymerase 2, BCL2 associated agonist of cell death, G2 and S-phase expressed 1 and PAX interacting protein 1 genes, described as prognostic markers in breast cancer in a previous microarray study, are also predictors of lymph node involvement in breast carcinoma Reverse transcription-quantitative polymerase chain reaction analysis was performed on primary breast tumor tissues from women with negative lymph node involvement (n=27) compared with primary tumor tissues from women with positive lymph node involvement (n=23), and was also performed on primary tumors and paired lymph node metastases (n=11). "
3.	Breast Neoplasms (Breast Cancer) 01/01/2017 - "The purpose of the present study was to determine whether protein phosphatase Mg2+/Mn2+ dependent 1D, β-1,3-N-acetylglucosaminyltransferase, neural precursor cell expressed, developmentally down-regulated 9, prohibitin, phosphoinositide-3-kinase regulatory subunit 5 (PIK3R5), phosphatidylinositol-5-phosphate 4-kinase type IIα, TRF1-interacting ankyrin-related ADP-ribose polymerase 2, BCL2 associated agonist of cell death, G2 and S-phase expressed 1 and PAX interacting protein 1 genes, described as prognostic markers in breast cancer in a previous microarray study, are also predictors of lymph node involvement in breast carcinoma Reverse transcription-quantitative polymerase chain reaction analysis was performed on primary breast tumor tissues from women with negative lymph node involvement (n=27) compared with primary tumor tissues from women with positive lymph node involvement (n=23), and was also performed on primary tumors and paired lymph node metastases (n=11). "
4.	Osteoarthritis 09/01/2022 - "Long non-coding RNA osteoarthritis non-coding transcript (OANCT) and phosphoinositide-3-kinase regulatory subunit 5 (PIK3R5) were depleted in DC-exo-treated macrophages and OA rats, in order to observe macrophage polarization and cartilage degradation. "
5.	Inflammation (Inflammations) 07/01/2019 - "The DEGs related to liver inflammation between control group and SNE group or SNE and BS15 groups, included cluster of differentiation 80 (CD80), Interleukin 1 beta (IL1B), Phosphoinositide 3- Kinase regulatory subunit 5 (PIK3R5), Toll-like receptor 4 (TLR4), Toll-like receptor 2 A (TLR2A), and proto-oncogene protein (FOS). "

Related Drugs and Biologics

1.	Ankyrins
2.	Proteins (Proteins, Gene)
3.	Phosphoprotein Phosphatases (Phosphatases, Protein)
4.	Adenosine Diphosphate Ribose (ADP-Ribose)
5.	Prohibitins
6.	phosphatidylinositol 5-phosphate
7.	Long Noncoding RNA
8.	Interleukin-1beta (Interleukin 1 beta)
9.	Toll-Like Receptor 4
10.	Toll-Like Receptor 2