A family of cell surface receptors that were originally identified by their structural homology to neurotropic TYROSINE KINASES and referred to as orphan receptors because the associated ligand and signaling pathways were unknown. Evidence for the functionality of these proteins has been established by experiments showing that disruption of the orphan receptor genes results in developmental defects.
Also Known As:
NTRKR Receptors; Neurotrophic Tyrosine Kinase, Receptor-related Proteins; ROR Tyrosine Kinase Receptors; ROR1 Tyrosine Kinase; ROR2 Tyrosine Kinase; Receptor Tyrosine Kinase-like Orphan Receptor 1; Receptor Tyrosine Kinase-like Orphan Receptor 2; Kinase, ROR2 Tyrosine; Neurotrophic Tyrosine Kinase, Receptor related Proteins; Receptor Tyrosine Kinase like Orphan Receptor; Receptor Tyrosine Kinase like Orphan Receptor 1; Receptor Tyrosine Kinase like Orphan Receptor 2; Receptor Tyrosine Kinase like Orphan Receptors; Tyrosine Kinase, ROR1; Receptor Tyrosine Kinase-like Orphan Receptor