Fatty Acid Synthesis Inhibitors

Compounds that interfere with FATTY ACID SYNTHASE resulting in a reduction of FATTY ACIDS. This is a target mechanism in humans of some ANTINEOPLASTIC AGENTS and ANTI-OBESITY AGENTS and of some ANTI-INFECTIVE AGENTS which interfere with CELL WALL and CELL MEMBRANE formation.

Networked: 2 relevant articles (0 outcomes, 0 trials/studies)

Bio-Agent Context: Research Results

Chemical Actions and Uses
- Pharmacologic Actions: 160
  - Molecular Mechanisms of Pharmacological Action: 24
    - Antimetabolites: 1599
      - Hypolipidemic Agents: 776
        Fatty Acid Synthesis Inhibitors: 2

Experts

1.	Cronan, John E: 1 article (04/2014)
2.	Biemann, Hans-Peter: 1 article (01/2012)
3.	Booker, Michael: 1 article (01/2012)
4.	Carter, Kara: 1 article (01/2012)
5.	Cohen, Aharon: 1 article (01/2012)
6.	Cooper, Christopher G F: 1 article (01/2012)
7.	Fremgen, Trisha: 1 article (01/2012)
8.	Hirth, Brad: 1 article (01/2012)
9.	Jancsics, Kate: 1 article (01/2012)
10.	Komarnitsky, Svetlana: 1 article (01/2012)

Related Diseases

1.	Neoplasms (Cancer) 01/01/2012 - "Our data outline an effective strategy for interrogation of on-mechanism potency and pathway-node-specificity of fatty acid synthesis inhibitors, establish an unambiguous link between fatty acid synthesis and cancer cell survival, and point toward SCD1 as a key target in this pathway."
2.	Infections 04/01/2014 - "In some (but not all) family members incorporation of the fatty acids present in human serum precludes the use of fatty acid synthesis inhibitors to treat infections. "

Related Drugs and Biologics

1.	Fatty Acids (Saturated Fatty Acids)