Carbasugars

Sugar analogs in which the ring oxygen is replaced by a methylene (CH2) carbon.

Also Known As:

Carba-Monosaccharides; Carba-Sugars; Pseudosugars; Carba Monosaccharide; Carba Monosaccharides; Carba Sugar; Carba Sugars; Carba-Monosaccharide; Carba-Sugar; Carbasugar; Pseudosugar

Networked: 5 relevant articles (0 outcomes, 1 trials/studies)

Bio-Agent Context: Research Results

Carbohydrates: 22023
- Carbasugars: 5

Experts

1.	Marquez, Victor E: 2 articles (09/2009 - 06/2002)
2.	Deigner, Hans-Peter: 1 article (02/2022)
3.	Klenk, Lukas: 1 article (02/2022)
4.	Mack, Tonia: 1 article (02/2022)
5.	Schmidt, Magnus S: 1 article (02/2022)
6.	Zorin, Alexandra: 1 article (02/2022)
7.	Fischer, Roland: 1 article (04/2017)
8.	Pabst, Bettina M: 1 article (04/2017)
9.	Paschke, Eduard: 1 article (04/2017)
10.	Rappitsch, Tanja: 1 article (04/2017)

Related Diseases

1.	Neoplasms (Cancer) 02/09/2022 - "In science, there are a wide range of research areas that are affected by, and involve, carbasugars, such as studies on enzyme inhibition, lectin-binding, and even HIV and cancer treatment. "
2.	Lysosomal Storage Diseases (Lysosomal Storage Disease) 04/18/2017 - "In line with reports by Reymond and Jäger on similar structures, these amine containing basic carbasugars are potent inhibitors of β-D-galactosidases and, for the first time, could be shown to act as pharmacological chaperones for GM1-gangliosidosis-associated lysosomal acid β-galactosidase mutant R201C, thus representing a new structural type of pharmacological chaperones for this lysosomal storage disease."
3.	Infections 09/10/2009 - "NRTIs based on the carbocyclic pseudosugar may offer an effective approach for the treatment of HIV-1 infections."
4.	Herpes Simplex 06/01/2002 - "Antitumor activity and metabolic activation of N-methanocarbathymidine, a novel thymidine analogue with a pseudosugar rigidly fixed in the northern conformation, in murine colon cancer cells expressing herpes simplex thymidine kinase."
5.	Type 2 Diabetes Mellitus (MODY) 01/01/2017 - "Carbasugar sodium-glucose cotransporter 2 (SGLT2) inhibitors are highly promising drug candidates for the treatment of Type 2 diabetes mellitus (T2DM). "

Related Drugs and Biologics

1.	Lectins
2.	Enzymes
3.	Sodium-Glucose Transport Proteins
4.	Thymidine Kinase
5.	Thymidine
6.	Galactosidases
7.	Amines
8.	Acids
9.	Sodium-Glucose Transporter 2 Inhibitors
10.	(north)-methanocarbathymidine