N-Ethylmaleimide-Sensitive Proteins (N-Ethylmaleimide-Sensitive Fusion Protein)
ATPases that are members of the AAA protein superfamily (ATPase family Associated with Diverse cellular Activities). The NSFs functions, acting in conjunction with SOLUBLE NSF ATTACHMENT PROTEINS (i.e. SNAPs, which have no relation to SNAP 25), are to dissociate SNARE complexes.
Also Known As:
N-Ethylmaleimide-Sensitive Fusion Protein; N-Ethylmaleimide-Sensitive ATPase; N-Ethylmaleimide-Sensitive Factor; N-Ethylmaleimide-Sensitive Factors; N-Ethylmaleimide-Sensitive Protein; NEM-Sensitive Fusion Proteins; NSF ATPase; ATPase, N-Ethylmaleimide-Sensitive; ATPase, NSF; N Ethylmaleimide Sensitive ATPase; N Ethylmaleimide Sensitive Factor; N Ethylmaleimide Sensitive Factors; N Ethylmaleimide Sensitive Fusion Protein; N Ethylmaleimide Sensitive Protein; N Ethylmaleimide Sensitive Proteins; NEM Sensitive Fusion Proteins
Networked: 60
relevant articles (0 outcomes,
6 trials/studies)
Bio-Agent Context: Research Results
Experts
1. | Hu, Bingren:
5 articles
(11/2021 - 01/2018)
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2. | Liu, Chunli:
5 articles
(11/2021 - 01/2018)
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3. | Yuan, Dong:
4 articles
(11/2021 - 01/2018)
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4. | Mukhopadhyay, Somshuvra:
3 articles
(11/2008 - 03/2007)
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5. | Sehgal, Pravin B:
3 articles
(11/2008 - 03/2007)
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6. | Lowenstein, Charles J:
3 articles
(12/2007 - 10/2003)
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7. | Hu, Kurt:
2 articles
(11/2021 - 01/2021)
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8. | Teramoto, Hironori:
2 articles
(11/2021 - 01/2021)
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9. | Dolai, Subhankar:
2 articles
(10/2021 - 01/2020)
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10. | Gaisano, Herbert Y:
2 articles
(10/2021 - 01/2020)
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Related Diseases
1. | Brain Ischemia (Cerebral Ischemia)
11/01/2021
- " This study investigates the cascades of NSF ATPase inactivation events, endolysosomal damage, cathepsin release, and neuronal death after focal brain ischemia. " 01/01/2018
- " This review article is to discuss a novel hypothesis that brain ischemia inactivates NSF ATPase, resulting in a cascade of events of disruption of the Golgi-endosome-lysosome pathway, release of cathepsin B (CTSB), and induction of mitochondrial outer membrane permeabilization (MOMP) during the postischemic phase. " 12/01/2014
- " Identification of differentially expressed proteins and validation of the changes of N-ethylmaleimide-sensitive factor in rats with focal cerebral ischemia after transection of the cervical sympathetic trunk." 01/01/2021
- " Brain ischemia damages the membrane fusion machinery co-operated by N-ethylmaleimide sensitive factor (NSF), soluble NSF attachment protein (SNAP), and soluble NSF attachment protein receptors (SNAREs), thus interrupting the membrane-to-membrane fusion between the late endosome and terminal lysosome. " 01/01/2018
- " This study is to investigate the cascade of events of NSF ATPase inactivation, resulting in a massive buildup of late endosomes (LEs) and fatal release of cathepsin B (CTSB) after transient cerebral ischemia using the 2-vessel occlusion with hypotension (2VO+Hypotension) global brain ischemia model. "
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2. | Transient Ischemic Attack
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3. | Mitochondrial Diseases (Mitochondrial Disease)
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4. | Hyperoxia
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5. | Tetanus
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Related Drugs and Biologics
Related Therapies and Procedures