A costimulatory ligand glycoprotein that contains a C2 and V-type IMMUNOGLOBULIN DOMAIN. It is expressed by ANTIGEN-PRESENTING CELLS and binds to CD28 ANTIGEN with high specificity and to CTLA-4 ANTIGEN with low specificity. The interaction of CD86 with CD28 ANTIGEN provides a stimulatory signal to T-LYMPHOCYTES, while its interaction with CTLA-4 ANTIGEN may play a role in inducing PERIPHERAL TOLERANCE.
Also Known As:
Antigen, B7-2; B70 Costimulatory Molecule; CD86 Antigen; Early T Cell Costimulatory Molecule 1; Antigen, B7 2; Antigen, CD86; B7 2 Antigen; Costimulatory Molecule, B7-2; Costimulatory Molecule, B70; Antigens, CD86; B7-2 Costimulatory Molecule; CD86 Antigens