Hepatocyte Nuclear Factors

Hepatocyte nuclear factors are a family of evolutionarily conserved transcription factors that are preferentially expressed in HEPATOCYTES. They play important roles in liver-specific transcription and are critical for CELL DIFFERENTIATION and METABOLISM.

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Networked: 435 relevant articles (7 outcomes, 40 trials/studies)

Relationship Network

Bio-Agent Context: Research Results

Experts

1.	Hattersley, Andrew T: 9 articles (01/2020 - 05/2003)
2.	Hattersley, A T: 9 articles (01/2013 - 01/2000)
3.	Yamagata, Kazuya: 8 articles (01/2017 - 01/2002)
4.	Yamagata, K: 8 articles (11/2007 - 01/2000)
5.	Ellard, Sian: 7 articles (01/2020 - 05/2003)
6.	Hansen, Torben: 7 articles (01/2020 - 04/2002)
7.	Sladek, Frances M: 7 articles (10/2015 - 02/2002)
8.	Matsuzawa, Y: 7 articles (04/2003 - 01/2000)
9.	Zhang, Yanqiao: 6 articles (05/2022 - 02/2011)
10.	Njølstad, P R: 6 articles (12/2016 - 12/2000)

Related Diseases

1.	Insulin Resistance 12/01/2017 - "Previous studies have suggested that hepatocyte nuclear factor 1b (HNF1b) ameliorates insulin resistance. " 01/01/2018 - "To determine whether weight-loss diets varying in macronutrients modulate the genetic effect of hepatocyte nuclear factor 1α (HNF1A) rs7957197 on weight loss and improvement of insulin resistance. " 01/01/2018 - "Although insulin secretion profiles from islets of sham and SG mice were indistinguishable, clamp studies revealed that SG causes a dramatic improvement in muscle and hepatic insulin sensitivity accompanied by hepatic regulation of hepatocyte nuclear factor-α and peroxisome proliferator-activated receptor-α targets. " 07/01/2005 - "Patients with diabetes due to hepatocyte nuclear factor (HNF)-1alpha mutations have beta-cell deficiency, insulin sensitivity, altered proinsulin levels, and a low renal threshold for glucose. "
2.	Carcinoma (Carcinomatosis) 11/23/2021 - "[Expression of hepatocyte nuclear factor 4γ in gastric carcinoma and its role in cell proliferation and stemness]." 05/01/2016 - "Hepatocyte nuclear factor 4α suppresses the aggravation of colon carcinoma." 04/01/2013 - "We previously found that enhanced expression of hepatocyte nuclear factor 4α (HNF-4α) is associated with hyper-proliferation of colon carcinoma cells. " 11/01/2011 - "Immunohistochemically, hepatocyte nuclear factor 4A was expressed in all 33 primary gastric carcinomas that were examined but was never expressed in metastatic breast carcinomas. " 03/01/2011 - "Immunohistochemical stains for p53, p16, ER, PR, mib-1, hepatocyte nuclear factor 1β and pan-cytokeratin can be helpful in classifying these high-grade carcinomas. "
3.	Fibrosis (Cirrhosis) 06/01/2013 - "The aim of this study was to determine whether cirrhosis could be reversed after treated with hepatocyte nuclear factor 4α (HNF4α), a key transcriptional regulator of hepatocyte differentiation and function. " 01/01/2016 - "More importantly, after Ad-TuD-21 treatment, inhibition of both the ERK1 signalling pathway in HSC and hepatocyte EMT was confirmed, which paralleled the enhancement of miR-21 target genes-sprouty2 (SPRY2) and hepatocyte nuclear factor 4α (HNF4α)-expression in vivo These data demonstrated that miR-21 is a key regulator to promote hepatic fibrogenesis, and sponging miR-21 expression may present a novel potentially therapeutic option for hepatic fibrosis." 02/01/2010 - "Hepatocyte nuclear factor 4alpha attenuates hepatic fibrosis in rats." 12/01/2021 - "Specifically, we aimed to demonstrate the therapeutic efficacy of human hepatocyte nuclear factor alpha (HNF4A) mRNA in mouse models of fibrosis and cirrhosis. " 02/20/2021 - "[Alteration on hepatocyte nuclear factor 1α expressions and significance in the process of occurrence and development of liver inflammation and fibrosis in patients with chronic hepatitis B]."
4.	Atherosclerosis 11/15/2023 - "This study aims to investigate the impact of hepatocyte nuclear factor 1β (HNF1b) on macrophage sortilin-mediated lipid metabolism and aortic atherosclerosis and explore the role of the flavone of Polygonatum odoratum (PAOA-flavone)-promoted small ubiquitin-related modifier (SUMO) modification in the atheroprotective efficacy of HNF1b. "
5.	Non-alcoholic Fatty Liver Disease 05/20/2022 - "Hepatocyte nuclear factor 4α in the pathogenesis of non-alcoholic fatty liver disease." 01/01/2023 - "As the rs7643645 G variant disrupts a putative hepatocyte nuclear factor 4α binding site located in the PXR gene promoter and is associated with lower hepatic expression of PXR and its target genes, our result suggests that genetic disruption of xenobiotic metabolism increases mortality in subjects with NAFLD. " 10/22/2022 - "Regulation of Hepatocyte Nuclear Factor 4α Attenuated Lipotoxicity but Increased Bile Acid Toxicity in Non-Alcoholic Fatty Liver Disease." 01/01/2020 - "Vitamin D receptor targets hepatocyte nuclear factor 4α and mediates protective effects of vitamin D in nonalcoholic fatty liver disease."

Related Drugs and Biologics

1.	Messenger RNA (mRNA)
2.	Peroxisome Proliferator-Activated Receptors (PPAR)
3.	Ubiquitin
4.	sortilin
5.	flavone
6.	salicylhydroxamic acid (SHAM)
7.	Calcitriol Receptors (Calcitriol Receptor)
8.	Vitamin D
9.	Keratins (Keratin)
10.	Transcription Factors (Transcription Factor)

Related Therapies and Procedures

1.	Precision Medicine
2.	Therapeutics
3.	Reducing Diet