Post-Dural Puncture Headache

A secondary headache disorder attributed to low CEREBROSPINAL FLUID pressure caused by SPINAL PUNCTURE, usually after dural or lumbar puncture.

Also Known As:

Post-Lumbar Puncture Headache; Postdural Puncture Headache; Headache, Post-Dural Puncture; Headache, Postdural Puncture; Headaches, Post-Dural Puncture; Headaches, Postdural Puncture; Post Dural Puncture Headache; Post-Dural Puncture Headaches; Postdural Puncture Headaches

Networked: 885 relevant articles (70 outcomes, 88 trials/studies)

Relationship Network

Disease Context: Research Results

Nervous System Diseases: 14737
- Central Nervous System Diseases: 4371
  - Brain Diseases: 16141
    - Headache Disorders: 1203
      - Secondary Headache Disorders: 360
        Post-Dural Puncture Headache: 885

Related Diseases

1.	Headache (Headaches)
2.	Intracranial Hypotension
3.	Neuralgia (Stump Neuralgia)
4.	Migraine Disorders (Migraine)
5.	Epilepsy (Aura)

Experts

1.	Kranke, Peter: 6 articles (02/2024 - 07/2011)
2.	Urits, Ivan: 6 articles (01/2021 - 01/2019)
3.	Lim, Grace: 5 articles (08/2023 - 09/2016)
4.	Vallejo, Manuel C: 5 articles (08/2023 - 08/2009)
5.	Hasoon, Jamal: 5 articles (01/2021 - 04/2020)
6.	Viswanath, Omar: 5 articles (01/2021 - 01/2019)
7.	Orbach-Zinger, S: 4 articles (01/2024 - 01/2019)
8.	Heesen, M: 4 articles (10/2023 - 01/2013)
9.	Ansari, Jessica: 4 articles (08/2023 - 01/2021)
10.	Volk, Thomas: 4 articles (08/2023 - 10/2017)

Drugs and Biologics

Drugs and Important Biological Agents (IBA) related to Post-Dural Puncture Headache:

1.	Caffeine (No Doz)FDA LinkGeneric 09/01/2007 - "Is caffeine effective in preventing and treating postdural puncture headache (PDPH)? " 12/01/1998 - "Well-designed studies are necessary to demonstrate the efficacy of oral caffeine (and other drugs) in post lumbar-puncture headache." 09/01/1992 - "Treatment with caffeine and hydration for presumed postdural puncture headache resulted in relief for approximately 1 hour. " 09/01/1987 - "Should caffeine become the first-line treatment for postdural puncture headache?" 09/01/2007 - "Caffeine for the prevention and treatment of postdural puncture headache: debunking the myth."
2.	Gabapentin (Neurontin)FDA LinkGeneric 07/01/2012 - "Gabapentin appears potentially beneficial in the management of patients with post-dural puncture headaches." 07/01/2012 - "Gabapentin in the treatment of post-dural puncture headache: a case series." 03/01/2007 - "Gabapentin relieves post-dural puncture headache--a report of two cases." 07/01/2014 - "Does preoperative gabapentin affects the characteristics of post-dural puncture headache in parturients undergoing cesarean section with spinal anesthesia?" 07/01/2014 - "Gabapentin is effective for treating different types of headache including post-dural puncture headache (PDPH), also used for prophylaxis against migraine. "
3.	Cosyntropin (Cortrosyn)FDA LinkGeneric 01/01/2012 - "Cosyntropin has been reported to be effective in the treatment of post-dural puncture headaches, but there is a lack of data on its effectiveness. " 01/08/2020 - "Evaluation of the effectiveness and tolerance of tetracosactide in the treatment of post-dural puncture headaches (ESYBRECHE): a study protocol for a randomised controlled trial." 11/01/2023 - "Role of cosyntropin in the prevention of post-dural puncture headache: a propensity-matched retrospective analysis." 11/01/2023 - "Research suggests that postpartum post-dural puncture headache (PDPH) might be prevented or treated by administering intravenous cosyntropin. " 11/01/2023 - "Role of cosyntropin in the management of postpartum post-dural puncture headache: a two-center retrospective cohort study."
4.	Sumatriptan (Imigran)FDA LinkGeneric 04/01/2000 - "Sumatriptan has been used successfully in patients with postdural puncture headache, however, its use has not been investigated in a controlled fashion. " 04/01/2000 - "Sumatriptan in patients with postdural puncture headache." 01/01/1999 - "The use of sumatriptan in the treatment of postdural puncture headache after accidental lumbar puncture complicated a blood patch procedure." 11/01/1997 - "[Failure of sumatriptan in post-dural puncture headache]." 11/01/1997 - "Sumatriptan and postdural puncture headache."
5.	Dexamethasone (Maxidex)FDA LinkGeneric 09/01/2014 - "Is epidural dexamethasone effective in preventing postdural puncture headache?" 01/01/2011 - "Dexamethasone in preventing post-dural puncture headache: a randomized, double-blind, placebo-controlled trial." 02/01/2017 - "Dexamethasone Increases the Frequency of Post-Dural Puncture Headache (PDPH): An Evidence Based Reality." 02/01/2014 - "Can dexamethasone reduce postdural puncture headache?" 02/01/2021 - "Dexamethasone and post-dural puncture headache in women who underwent cesarean delivery under spinal anesthesia: A systemic review and meta-analysis of randomized controlled trials."
6.	Morphine (MS Contin)FDA LinkGeneric 01/01/2020 - "Prophylactic Intrathecal Morphine and Prevention of Post-Dural Puncture Headache: A Randomized Double-blind Trial: Erratum." 01/01/2020 - "Prophylactic Intrathecal Morphine and Prevention of Post-Dural Puncture Headache: A Randomized Double-blind Trial." 01/01/1992 - "It is concluded from our study that subarachnoid morphine did not decrease the incidence of post dural puncture headache in the obstetric patient." 01/01/2023 - "Effect of Intrathecal Morphine on Postdural Puncture Headache in Obstetric Anaesthesia." 01/01/2020 - "The incidence of post-dural puncture headache was 21 of 27 (78%) in the intrathecal morphine group and 27 of 34 (79%) in the intrathecal saline group (difference, -1%; 95% CI, -25% to 24%). "
7.	Anesthetics (Anesthetic Agents)IBA 12/01/1998 - "There was one adverse anesthetic outcome among the 1,300 women in the study; the woman sustained a post-dural puncture headache. " 12/01/2019 - "Of the 32,655 neuraxial anesthetics performed, 298 (0.9%) patients experienced a post- dural puncture headache. " 11/01/2018 - "Anesthetic approach to postdural puncture headache in the peripartum period: An Israeli national survey." 10/01/2018 - "On the first postoperative day, the patient expressed satisfaction with the anesthetic plan and, in particular, the avoidance of a neuraxial technique and postdural puncture headache. " 07/01/2018 - "Although it is a reliable and frequently used anesthetic procedure, it involves complications, including postdural puncture headache caused by arachnoid punctured, which significantly affects postoperative well-being. "
8.	Hydrocortisone (Cortisol)FDA LinkGeneric 04/01/2012 - "The efficacy of intravenous (IV) hydrocortisone in treating the patients with postdural puncture headache was observed in this study. " 04/01/2012 - "Role of very short-term intravenous hydrocortisone in reducing postdural puncture headache." 06/01/2005 - "Three cases in which hydrocortisone was used to treat and prevent post-dural puncture headache are reported. " 06/01/2005 - "This report aimed at describing the use of hydrocortisone to treat and prevent post-dural puncture headache (PDPH). " 06/01/2005 - "[Hydrocortisone treatment and prevent post-dural puncture headache: case reports]."
9.	Analgesics (Analgesic Drugs)IBA 07/01/2011 - "Only two patients (3%) had postdural puncture headache controlled with simple analgesics. " 01/01/2019 - "The most frequently mentioned topics were benefits, effects of epidural analgesia on labor and delivery, definitions, post-dural puncture headache and alternative analgesics. " 11/01/2021 - "Post dural puncture headache (PDPH) is considered a potential complication of this analgesic technique and is a frequently hypothesis for any headache occurring after delivery. " 01/28/2021 - "Post dural puncture headache (PDPH) is considered a potential complication of this analgesic technique and is a frequently hypothesis for any headache occurring after delivery. " 01/01/2017 - "The most frequent complication was headache (6.25%); only one subject reported a typical post-lumbar puncture headache with moderate severity that required analgesic treatment. "
10.	Uridine Diphosphate (UDP)IBA 10/01/2016 - "UDP is associated with maternal adverse outcomes, with the most frequent adverse outcome being postdural puncture headache (PDPH). " 01/01/2023 - "Post-dural puncture headache (PDPH) is particularly likely to happen in patients under obstetric care due to an unintentional dural puncture (UDP). " 11/01/2001 - "To assess the time of occurrence, circumstances and presenting symptoms of unintentional dural puncture (UDP), the location and intensity of postdural puncture headaches (PDPH), and the efficacy of their treatment by epidural blood-patch (EBP). " 05/01/2022 - "The most common complication associated with labor epidural analgesia (LEA) is Unintentional Dural Puncture (UDP), where many professionals go on to develop a Post Dural Puncture Headache (PDPH). " 10/01/2021 - "This narrative literature review examines the long-term impact of postdural puncture headache (PDPH) in postpartum women following an unintended dural puncture (UDP) with a large bore needle commonly used for epidural catheter placement. "

Therapies and Procedures

1.	Epidural Blood Patch 06/01/2022 - "One patient had a postdural puncture headache that resolved completely after a transforaminal epidural blood patch performed 4 days later. " 02/01/1997 - "Epidural blood patch may give immediate relief of postdural puncture headache and cranial nerve dysfunction after lumbar puncture, but the reason for the rapid and impressive effect of epidural blood patch has not been fully elucidated." 06/01/1990 - "A case is presented of a 12-year-old boy with a post-lumbar puncture headache of 6 weeks duration that was treated successfully with an epidural blood patch. " 02/28/2019 - "Autologous epidural blood patch (AEBP) is effective for post-dural-puncture headache (PDPH). " 11/01/2015 - "The elderly may also develop postdural puncture headache, and epidural blood patch is an effective and well-tolerated treatment of persistent and severe symptoms."
2.	Punctures 05/01/1997 - "Geometry may help to explain the reduced rate of postdural puncture headache found with Quincke bevels oriented to face laterally during midline approach and during paramedian technique, particularly when a single puncture results in aspiration of cerebrospinal fluid." 07/20/2023 - "We conducted a retrospective single-centred study to define incidence and risk factors of accidental dural puncture and post-dural puncture headache in an obstetric population. " 02/01/2016 - "Further rigorous studies are needed to help determine the best methods to decrease the incidence of postdural puncture headache in obstetric patients experiencing an accidental dural puncture during epidural placement." 02/01/1996 - "Previous studies have failed to find a significant correlation between the number of dural punctures and the incidence of postdural puncture headache (PDPH), questioning the hypothesis that leakage of cerebrospinal fluid (CSF) through the dural tear is the cause of PDPH. " 03/30/2024 - "We identified independent association factors suggesting that greater epidural depth and procedure difficulty may increase the odds of inadvertent dural puncture or post-dural puncture headache."
3.	Therapeutics 03/29/2023 - "Efficacy of pharmacological therapies for preventing post-dural puncture headaches in obstetric patients: a Bayesian network meta-analysis of randomized controlled trials." 06/01/2024 - "Efficacy of therapies for post dural puncture headache." 11/01/2021 - "No major adverse events were reported, and two post dural puncture headaches were managed with medical therapy and with complete resolution within 72 h. " 01/01/2018 - "Among patients who had lumbar puncture, atraumatic needles were associated with a decrease in the incidence of postdural-puncture headache and in the need for patients to return to hospital for additional therapy, and had similar efficacy to conventional needles. " 08/01/2014 - "This case emphasises the need to consider the differential diagnoses of post-dural puncture headache and to highlight the warning signs in patients who do not respond despite treatment with conventional therapy. "
4.	Nerve Block (Nerve Blocks) 04/01/2018 - "Efficacy of bilateral greater occipital nerve block in postdural puncture headache: a narrative review." 01/01/2015 - " this study the efficacy of bilateral occipital nerve block was retrospectively evaluated in patients with post-dural puncture headache. " 12/23/2021 - "This study aimed at assessing the therapeutic effectiveness of greater occipital nerve block (GONB) against postdural puncture headache (PDPH). " 06/16/2023 - "Post-dural puncture headache (PDPH) is the most common complication of intraspinal nerve block in gravida. " 01/01/2023 - "Bilateral Greater Occipital Nerve Block; Distal Versus Proximal Approach for Postdural Puncture Headache: A Randomized Clinical Trial."
5.	Sphenopalatine Ganglion Block 10/01/2022 - "A randomized control study to assess the efficacy of the sphenopalatine ganglion block in patients with post dural puncture headache." 01/01/2022 - "The efficacy of sphenopalatine ganglion block for the treatment of postdural puncture headache among obstetric population." 01/01/2021 - "To evaluate the efficacy of modified sphenopalatine ganglion block (MSPGB) to reduce the severity of post-dural puncture headache (PDPH). " 11/01/2023 - "Trans-nasal sphenopalatine ganglion block for post-dural puncture headache management: a meta-analysis of randomized trials." 01/01/2024 - "Sphenopalatine ganglion blocks for post-dural puncture headache: A case report in a 3-year-old child."