Complement C5b
The larger fragment generated from the cleavage of C5 by C5 CONVERTASE that yields COMPLEMENT C5A and C5b (beta chain + alpha' chain, the residual alpha chain, bound by disulfide bond). C5b remains bound to the membrane and initiates the spontaneous assembly of the late complement components to form C5b-8-poly-C9, the MEMBRANE ATTACK COMPLEX.
Also Known As:
C5b Complement; Complement 5b; Complement Component 5b; C5b, Complement; Complement, C5b; Component 5b, Complement; Complement C 5b
Networked: 2
relevant articles (0 outcomes,
0 trials/studies)
Bio-Agent Context: Research Results
Experts
1. | Aliskevich, Emily:
1 article
(01/2021)
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2. | Boyd, Ryan:
1 article
(01/2021)
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3. | Browder, Kyle F:
1 article
(01/2021)
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4. | Burgin, Michelle:
1 article
(01/2021)
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5. | Fromme, Petra:
1 article
(01/2021)
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6. | Guo, Qiuyun:
1 article
(01/2021)
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7. | Lucas, Alexandra R:
1 article
(01/2021)
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8. | Olson, Tien L:
1 article
(01/2021)
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9. | Schutz, Lauren N:
1 article
(01/2021)
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10. | Ulrich, Peaches:
1 article
(01/2021)
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Related Diseases
1. | Inflammation (Inflammations)
01/01/2021
- " Both Serp-1m5 and Serp-1 treatment reduced perivascular inflammation and reduced M1 macrophage (Serp-1, p = 0.0350; Serp-1m5, p = 0.0053), hemosiderin-laden macrophage (Serp-1, p = 0.0370; Serp-1m5, p = 0.0424) invasion, and complement C5b/9 staining. " 12/01/2008
- " In contrast, significant inflammation was observed in HCDM-implanted animals, as evidenced by immune cell infiltration (p </= 0.0001), immunoglobulin G (IgG) binding (p < 0.001), complement (C5b) deposition (p < 0.05), TNF-alpha deposition (p < 0.001), and macrophage activation (p < 0.05). "
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