Childhood Nervous System Lead Poisoning

Neurologic disorders occurring in children following lead exposure. The most frequent manifestation of childhood lead toxicity is an encephalopathy associated with chronic ingestion of lead that usually presents between the ages of 1 and 3 years. Clinical manifestations include behavioral changes followed by lethargy; CONVULSIONS; HALLUCINATIONS; DELIRIUM; ATAXIA; and vomiting. Elevated intracranial pressure (HYPERTENSION, INTRACRANIAL) and CEREBRAL EDEMA may occur. (From Adams et al., Principles of Neurology, 6th ed, p1210-2)

Also Known As:

Lead Poisoning, Nervous System, Childhood; Saturine Encephalopathy, Childhood; Childhood Lead Encephalopathy; Childhood Neurologic Saturnism; Childhood Saturine Encephalopathy; Encephalopathy, Childhood Lead; Encephalopathy, Childhood Saturine; Lead Induced Nervous System Disease, Childhood; Saturnism, Childhood Neurologic; Lead Encephalopathy, Childhood; Lead Poisoning, Neurologic, Childhood; Lead-Induced Nervous System Disease, Childhood; Nervous System Disease, Lead-Induced, Childhood; Nervous System Poisoning, Lead, Childhood; Neurologic Saturnism, Childhood; Neurotoxicity Syndrome, Lead, Childhood; Plumbism, Neurologic, Childhood; Poisoning, Lead, Nervous System, Childhood; Poisoning, Lead, Neurologic, Childhood

Networked: 1 relevant articles (0 outcomes, 0 trials/studies)

Disease Context: Research Results

Drugs and Biologics

Drugs and Important Biological Agents (IBA) related to Childhood Nervous System Lead Poisoning:

1.	flavopereirine (PB 100)IBA 03/01/1983 - "In human childhood lead encephalopathy, which occurs with blood lead levels in the range 100-800 micrograms Pb/100 ml, oedema, vacuolation, haemorrhage and reactive glial changes appear to be secondary to microvascular lesions. "