A subfamily of transmembrane proteins from the superfamily of ATP-BINDING CASSETTE TRANSPORTERS that are closely related in sequence to ATP BINDING CASSETTE TRANSPORTER, SUBFAMILY B, MEMBER 1. When overexpressed, they function as ATP-dependent efflux pumps able to extrude lipophilic drugs (especially ANTINEOPLASTIC AGENTS) from cells, causing multidrug resistance (DRUG RESISTANCE, MULTIPLE). Although ATP BINDING CASSETTE TRANSPORTER, SUBFAMILY B share functional similarities to MULTIDRUG RESISTANCE-ASSOCIATED PROTEINS they are two distinct subclasses of ATP-BINDING CASSETTE TRANSPORTERS, and have little sequence homology.
Also Known As:
ATP Binding Cassette Transporter, Subfamily B; ATP Binding Cassette Transporter, Sub-Family B; ATP-Binding Cassette, Sub-Family B Proteins; ATP Binding Cassette Transporter, Sub Family B; ATP Binding Cassette, Sub Family B Proteins; P Glycoproteins; Multidrug Resistance Proteins; P-Glycoproteins